LAG3 抗体
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北京 101111
Quick Overview for LAG3 抗体 (ABIN1169112)
抗原
See all LAG3 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Recognizes human and monkey LAG-3.
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交叉反应
- 人, 猴
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纯化方法
- Purified from concentrated hybridoma tissue culture supernatant.
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纯度
- >95 % (SDS-PAGE)
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内毒素水平
- <0.001EU/μg purified protein or <1EU/mg purified protein (LAL test, Lonza).
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免疫原
- Recombinant human LAG-3.
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亚型
- IgG1
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anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 66-199) antibody
LAG3 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 4H6A3 unconjugated
anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 103-132) antibodyLAG3 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21775 unconjugated
anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 103-132) antibodyLAG3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 29-450) antibodyLAG3 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 8B12E10 unconjugated
anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 1-360) antibodyLAG3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 201-300) antibodyLAG3 适用: 人, 小鼠 WB, ELISA, ICC, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 244-487) antibodyLAG3 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 209-451) antibodyLAG3 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 29-450) antibodyLAG3 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Lymphocyte-Activation Gene 3 (LAG3) antibodyLAG3 适用: 小鼠 FACS 宿主: 大鼠 Monoclonal C9B7W unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- In PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. -
有效期
- 12 months
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: "Clonal regulatory T cells specific for a red blood cell autoantigen in human autoimmune hemolytic anemia." in: Blood, Vol. 111, Issue 2, pp. 680-7, (2008) (PubMed).
: "A soluble lymphocyte activation gene-3 (sLAG-3) protein as a prognostic factor in human breast cancer expressing estrogen or progesterone receptors." in: Cancer letters, Vol. 235, Issue 1, pp. 147-53, (2006) (PubMed).
: "Characterization of the major histocompatibility complex class II binding site on LAG-3 protein." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 11, pp. 5744-9, (1997) (PubMed).
: "Cellular expression and tissue distribution of the human LAG-3-encoded protein, an MHC class II ligand." in: Immunogenetics, Vol. 39, Issue 3, pp. 213-7, (1994) (PubMed).
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: "Clonal regulatory T cells specific for a red blood cell autoantigen in human autoimmune hemolytic anemia." in: Blood, Vol. 111, Issue 2, pp. 680-7, (2008) (PubMed).
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- LAG3 (Lymphocyte-Activation Gene 3 (LAG3))
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别名
- LAG-3
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背景
- Lymphocyte activation gene 3 (LAG-3, CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.
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UniProt
- P18627
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途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
抗原
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