NAMPT 抗体 (Nicotinamide phosphoribosyltransferase)

Details for Product anti-NAMPT Antibody No. ABIN1169028, 供应商: Log in to see
抗原
  • 1110035O14Rik
  • PBEF
  • PBEF1
  • VF
  • VISFATIN
  • AI314458
  • AI480535
  • NAmPRTase
  • Pbef
  • Pbef1
  • Visfatin
  • visfatin
  • pbef
  • pbef1
  • nicotinamide phosphoribosyltransferase
  • Nicotinamide phosphoribosyltransferase
  • nicotinamide phosphoribosyltransferase S homeolog
  • NAMPT
  • Nampt
  • nampt
  • Smon_0680
  • Mrub_2845
  • Cseg_3704
  • BC1002_3997
  • Ftrac_2686
  • Varpa_5681
  • Celal_3900
  • Deima_0880
  • BC1001_3724
  • Celly_1696
  • Clole_1542
  • Tsp_05934
  • nampt.S
适用
人, 小鼠, 大鼠
359
147
118
25
13
11
8
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5
4
4
3
1
1
宿主
小鼠
322
61
9
9
6
2
克隆类型 (克隆位点)
单克隆 ()
标记
This NAMPT antibody is un-conjugated
45
17
9
9
7
6
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6
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3
3
3
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2
2
2
2
2
2
2
2
2
2
1
应用范围
Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
263
189
132
51
51
50
37
29
25
16
11
4
4
3
3
3
2
1
1
1
1
选项
Supplier
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Supplier Product No.
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免疫原 Recombinant human Nampt (visfatin/PBEF).
克隆位点 OMNI379
亚型 IgG2a
特异性 Recognizes human, mouse and rat Nampt.
交叉反应 人, 小鼠, 大鼠
过滤 0.2 μm filtered
Plasmids, Primers & others Plasmids, Primers & others NAMPT products on genomics-online (e.g. as negative or positive controls)
抗原
别名 Nampt (Visfatin/PBEF) (NAMPT Antibody 摘要)
背景 Nicotinamide phosphoribosyltransferase (Nampt, pre-B cell colony-enhancing factor, PBEF, Visfatin) is an 52 kDa adipokine secreted by adipose tissue and involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Two forms of Nampt exist, an intracellular form (iNampt) and an extracellular form (eNampt). While the function of iNampt as an essential and rate-limiting NAD+ biosynthetic enzyme is well established, the physiological role of eNampt is still a matter of debate. Nampt has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.
UniProt P43490
应用备注 Optimal working dilution should be determined by the investigator.
限制 仅限研究用
状态 Liquid
浓度 1 mg/mL
缓冲液 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.
储存液 Without preservative
储存条件 4 °C,-20 °C
储存方法 Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.
有效期 12 months
厂商提供的图像
Immunofluorescence (IF) image for anti-Nicotinamide phosphoribosyltransferase (NAMPT) antibody (ABIN1169028) Immunofluorescent confocal imaging of HEK293 cells using anti-Nampt (Visfatin-PBEF), ...
Immunohistochemistry (IHC) image for anti-Nicotinamide phosphoribosyltransferase (NAMPT) antibody (ABIN1169028) Immunohistochemical staining of Nampt using anti-Nampt (OMNI379) in human kidney tis...
Western Blotting (WB) image for anti-Nicotinamide phosphoribosyltransferase (NAMPT) antibody (ABIN1169028) Western blot analysis of 3T3-L1 cell lysate using anti-Nampt (Visfatin/PBEF) mAb (OMN...
Western Blotting (WB) image for anti-Nicotinamide phosphoribosyltransferase (NAMPT) antibody (ABIN1169028) Immunoprecipitation of recombinant human Nampt (Visfatin/PBEF) proteins using anti-Na...
Western Blotting (WB) image for anti-Nicotinamide phosphoribosyltransferase (NAMPT) antibody (ABIN1169028) Western blot analysis using anti-Nampt (Visfatin-PBEF), mAb (OMNI379) at 1:2000 dilu...
Immunohistochemistry (IHC) image for anti-Nicotinamide phosphoribosyltransferase (NAMPT) antibody (ABIN1169028) Immunohistochemical staining of Nampt using anti-Nampt (Visfatin/PBEF), mAb (OMNI379)...
有引用在: Audrito, Serra, Brusa, Mazzola, Arruga, Vaisitti, Coscia, Maffei, Rossi, Wang, Inghirami, Rizzi, Gaidano, Garcia, Wolberger, Raffaelli, Deaglio: "Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia." in: Blood, Vol. 125, Issue 1, pp. 111-23, 2015 (PubMed).

Yoon, Yoshida, Johnson, Takikawa, Usui, Tobe, Nakagawa, Yoshino, Imai: "SIRT1-Mediated eNAMPT Secretion from Adipose Tissue Regulates Hypothalamic NAD+ and Function in Mice." in: Cell metabolism, Vol. 21, Issue 5, pp. 706-17, 2015 (PubMed).

Kover, Tong, Watkins, Clements, Stehno-Bittel, Novikova, Bittel, Kibiryeva, Stuhlsatz, Yan, Ye, Moore: "Expression and regulation of nampt in human islets." in: PLoS ONE, Vol. 8, Issue 3, pp. e58767, 2013 (PubMed).

Garten, Petzold, Barnikol-Oettler, Körner, Thasler, Kratzsch, Kiess, Gebhardt: "Nicotinamide phosphoribosyltransferase (NAMPT/PBEF/visfatin) is constitutively released from human hepatocytes." in: Biochemical and biophysical research communications, Vol. 391, Issue 1, pp. 376-81, 2010 (PubMed).

Körner, Garten, Blüher, Tauscher, Kratzsch, Kiess: "Molecular characteristics of serum visfatin and differential detection by immunoassays." in: The Journal of clinical endocrinology and metabolism, Vol. 92, Issue 12, pp. 4783-91, 2007 (PubMed).

Revollo, Körner, Mills, Satoh, Wang, Garten, Dasgupta, Sasaki, Wolberger, Townsend, Milbrandt, Kiess, Imai: "Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme." in: Cell metabolism, Vol. 6, Issue 5, pp. 363-75, 2007 (PubMed).

Bae, Kim, Kim, Kim, Koo, Jang, Yun, Yoo, Bae: "Hypoxic induction of human visfatin gene is directly mediated by hypoxia-inducible factor-1." in: FEBS letters, Vol. 580, Issue 17, pp. 4105-13, 2006 (PubMed).

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