NAMPT 抗体
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北京 101111
Quick Overview for NAMPT 抗体 (ABIN1169028)
抗原
See all NAMPT 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- anti-Nampt (Visfatin/PBEF), mAb (OMNI379)
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特异性
- Recognizes human, mouse and rat Nampt.
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产品特性
- Monoclonal Antibody. Recognizes human, mouse and rat Nampt. Isotype: Mouse IgG2akappa. Clone: OMNI379. Applications: ELISA, FACS, ICC, IHC, IP, WB. Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives. Nicotinamide phosphoribosyltransferase (Nampt, pre-B cell colony-enhancing factor, PBEF, Visfatin) is an 52 kDa adipokine secreted by adipose tissue and involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Two forms of Nampt exist, an intracellular form (iNampt) and an extracellular form (eNampt). While the function of iNampt as an essential and rate-limiting NAD+ biosynthetic enzyme is well established, the physiological role of eNampt is still a matter of debate. Nampt has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.
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过滤
- 0.2 μm filtered
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免疫原
- Recombinant human Nampt (visfatin/PBEF).
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亚型
- IgG2a kappa
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anti-Nicotinamide phosphoribosyltransferase (NAMPT) antibody (Biotin)
NAMPT 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, ICC 宿主: 小鼠 Monoclonal OMNI379 Biotin
anti-Nicotinamide phosphoribosyltransferase (NAMPT) (AA 1-491) antibodyNAMPT 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nicotinamide phosphoribosyltransferase (NAMPT) antibodyKD Validated NAMPT 适用: 人 WB, FACS, IF (p) 宿主: 兔 Monoclonal 25GB255 unconjugated Recombinant Antibody
anti-Nicotinamide phosphoribosyltransferase (NAMPT) (AA 62-337) antibodyNAMPT 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, ICC, IF, FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Nicotinamide phosphoribosyltransferase (NAMPT) (AA 301-400) antibodyNAMPT 适用: 人 WB, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Nicotinamide phosphoribosyltransferase (NAMPT) (AA 400-426) antibodyNAMPT 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB22920 unconjugated
anti-Nicotinamide phosphoribosyltransferase (NAMPT) (AA 1-280) antibodyNAMPT 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Nicotinamide phosphoribosyltransferase (NAMPT) (AA 400-426) antibodyNAMPT 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Nicotinamide phosphoribosyltransferase (NAMPT) (C-Term) antibodyNAMPT 适用: 人, 大鼠, 小鼠 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Nicotinamide phosphoribosyltransferase (NAMPT) (AA 1-280) antibodyNAMPT 适用: 人 IHC, ELISA, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 0.2μm-filtered solution in PBS, pH 7.4.
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储存液
- Without preservative
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注意事项
- After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.
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储存条件
- 4 °C,-20 °C
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储存方法
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+4°C
-20°C
Stable for at least 1 year after receipt when stored at -20°C.
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有效期
- 12 months
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: "Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia." in: Blood, Vol. 125, Issue 1, pp. 111-23, (2015) (PubMed).
: "SIRT1-Mediated eNAMPT Secretion from Adipose Tissue Regulates Hypothalamic NAD+ and Function in Mice." in: Cell metabolism, Vol. 21, Issue 5, pp. 706-17, (2015) (PubMed).
: "Expression and regulation of nampt in human islets." in: PLoS ONE, Vol. 8, Issue 3, pp. e58767, (2013) (PubMed).
: "Nicotinamide phosphoribosyltransferase (NAMPT/PBEF/visfatin) is constitutively released from human hepatocytes." in: Biochemical and biophysical research communications, Vol. 391, Issue 1, pp. 376-81, (2010) (PubMed).
: "Molecular characteristics of serum visfatin and differential detection by immunoassays." in: The Journal of clinical endocrinology and metabolism, Vol. 92, Issue 12, pp. 4783-91, (2007) (PubMed).
: "Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme." in: Cell metabolism, Vol. 6, Issue 5, pp. 363-75, (2007) (PubMed).
: "Hypoxic induction of human visfatin gene is directly mediated by hypoxia-inducible factor-1." in: FEBS letters, Vol. 580, Issue 17, pp. 4105-13, (2006) (PubMed).
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- NAMPT (Nicotinamide phosphoribosyltransferase (NAMPT))
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别名
- Nampt (Visfatin/PBEF)
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背景
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Alternate Names/Synonyms: Pre-B Cell Colony Enhancing Factor 1, PBEF1, Nicotinamide Phosphoribosyltransferase
Product Description: Nicotinamide phosphoribosyltransferase (Nampt, pre-B cell colony-enhancing factor, PBEF, Visfatin) is an 52 kDa adipokine secreted by adipose tissue and involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Two forms of Nampt exist, an intracellular form (iNampt) and an extracellular form (eNampt). While the function of iNampt as an essential and rate-limiting NAD+ biosynthetic enzyme is well established, the physiological role of eNampt is still a matter of debate. Nampt has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.
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UniProt
- P43490
抗原
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