(8 references)-
- 抗原 See all CD40 抗体
- CD40
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适用
- 小鼠
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宿主
- 大鼠
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克隆类型
- 单克隆
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标记
- This CD40 antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS), Functional Studies (Func)
- 特异性
- Recognizes mouse CD40.
- 交叉反应
- 小鼠
- 纯化方法
- Purified from concentrated hybridoma tissue culture supernatant.
- 纯度
- >95 % (SDS-PAGE)
- 内毒素水平
- <0.01EU/μg purified protein (LAL test, Lonza).
- 免疫原
- Recombinant mouse CD40 fusion protein.
- 克隆位点
- FGK45
- 亚型
- IgG2a
- Top Product
- Discover our top product CD40 Primary Antibody
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anti-CD40 (CD40) (AA 26-187) antibody
CD40 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-CD40 (CD40) antibodyCD40 适用: 人 FACS, IHC, IF, StM, DNA Mic 宿主: 小鼠 Monoclonal C40-1605 unconjugated
anti-CD40 (CD40) (AA 29-107) antibodyCD40 适用: 人 FACS, ELISA, IHC, StM, Coat 宿主: 小鼠 Monoclonal C40-2383 unconjugated
anti-CD40 (CD40) (C-Term) antibodyCD40 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-CD40 (CD40) (AA 21-193) antibodyCD40 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 4C3B8 unconjugated
anti-CD40 (CD40) (Extracellular Domain) antibodyCD40 适用: 人 FACS, IHC, St 宿主: 小鼠 Monoclonal 5C3 unconjugated
anti-CD40 (CD40) (AA 1-360) antibodyCD40 适用: 人, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-CD40 (CD40) antibodyCD40 适用: 人 FACS, IHC, IP, Act 宿主: 兔 Chimeric G28-5 unconjugated Recombinant Antibody
anti-CD40 (CD40) antibodyCD40 适用: 人 FACS 宿主: 小鼠 Monoclonal HI40a unconjugated
anti-CD40 (CD40) antibody (FITC)CD40 适用: 人 FACS 宿主: 小鼠 Monoclonal HI40a FITC
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 说明
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Widely used stimulatory MAb to CD40. Shown to indirectly activate natural killer (NK) cells, producing significant antitumor and antimetastatic effects. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- In PBS containing 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. - 有效期
- 12 months
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: "In vivo and in vitro regulation of type I IFN synthesis by synergistic effects of CD40 and type II IFN." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 10, pp. 5995-6003, (2006) (PubMed).
: "IL-10- and IL-12-independent down-regulation of allergic sensitization by stimulation of CD40 signaling." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 8, pp. 5138-44, (2006) (PubMed).
: "IRF-7 is the master regulator of type-I interferon-dependent immune responses." in: Nature, Vol. 434, Issue 7034, pp. 772-7, (2005) (PubMed).
: "Ovarian insufficiency and early pregnancy loss induced by activation of the innate immune system." in: The Journal of clinical investigation, Vol. 114, Issue 1, pp. 39-48, (2004) (PubMed).
: "CD154 is a negative regulator of autoaggressive CD8+ T cells in type 1 diabetes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 25, pp. 9345-50, (2004) (PubMed).
: "Anti-CD40 antibody induces antitumor and antimetastatic effects: the role of NK cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 1, pp. 89-94, (2001) (PubMed).
: "Therapeutic activity of agonistic monoclonal antibodies against CD40 in a chronic autoimmune inflammatory process." in: Nature medicine, Vol. 6, Issue 6, pp. 673-9, (2000) (PubMed).
: "Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity." in: European journal of immunology, Vol. 28, Issue 11, pp. 3738-48, (1998) (PubMed).
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: "In vivo and in vitro regulation of type I IFN synthesis by synergistic effects of CD40 and type II IFN." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 10, pp. 5995-6003, (2006) (PubMed).
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- 抗原
- CD40
- 别名
- CD40 (CD40 产品)
- 背景
- CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.
- UniProt
- P27512
- 途径
- NF-kappaB Signaling, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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