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CD40 抗体

Name: CD40 抗体
Brand: antibodies-online
SKU: ABIN1169011
Availability: OutOfStock

This anti-CD40 antibody is a 大鼠单克隆 antibody detecting CD40 in FACS 和 Func. Suitable for 小鼠. This Primary Antibody has been cited in 8+ publications.

(8 references)

产品编号 ABIN1169011

发货至: 中国

Quick Overview for CD40 抗体 (ABIN1169011)

抗原

See all CD40 抗体

CD40

适用

小鼠

宿主

大鼠

克隆类型

单克隆

标记

This CD40 antibody is un-conjugated

应用范围

Flow Cytometry (FACS), Functional Studies (Func)

克隆位点

FGK45

Discover our top product CD40 Primary Antibody

特异性

Recognizes mouse CD40.

交叉反应

小鼠

纯化方法

Purified from concentrated hybridoma tissue culture supernatant.

纯度

>95 % (SDS-PAGE)

内毒素水平

<0.01EU/μg purified protein (LAL test, Lonza).

免疫原

Recombinant mouse CD40 fusion protein.

亚型

IgG2a
anti-CD40 (CD40) (AA 26-187) antibody
CD40 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-CD40 (CD40) antibody
CD40 适用: 人 FACS, IHC, IF, StM, DNA Mic 宿主: 小鼠 Monoclonal C40-1605 unconjugated

anti-CD40 (CD40) (AA 29-107) antibody
CD40 适用: 人 FACS, ELISA, IHC, StM, Coat 宿主: 小鼠 Monoclonal C40-2383 unconjugated

anti-CD40 (CD40) (C-Term) antibody
CD40 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-CD40 (CD40) (AA 21-193) antibody
CD40 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 4C3B8 unconjugated

anti-CD40 (CD40) (Extracellular Domain) antibody
CD40 适用: 人 FACS, IHC, St 宿主: 小鼠 Monoclonal 5C3 unconjugated

anti-CD40 (CD40) (AA 1-360) antibody
CD40 适用: 人, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-CD40 (CD40) antibody
CD40 适用: 人 FACS, IHC, IP, Act 宿主: 兔 Chimeric G28-5 unconjugated Recombinant Antibody

anti-CD40 (CD40) antibody
CD40 适用: 人 FACS 宿主: 小鼠 Monoclonal HI40a unconjugated

anti-CD40 (CD40) antibody (FITC)
CD40 适用: 人 FACS 宿主: 小鼠 Monoclonal HI40a FITC

应用备注

Optimal working dilution should be determined by the investigator.

说明

Widely used stimulatory MAb to CD40. Shown to indirectly activate natural killer (NK) cells, producing significant antitumor and antimetastatic effects. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes.

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

In PBS containing 0.02 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

有效期

12 months
Greene, DeVecchio, Gould, Auletta, Heinzel: "In vivo and in vitro regulation of type I IFN synthesis by synergistic effects of CD40 and type II IFN." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 10, pp. 5995-6003, (2006) (PubMed).

Hellings, Kasran, Bullens, Overbergh, Mathieu, Heremans, Matthys, Boon, Jorissen, Ceuppens: "IL-10- and IL-12-independent down-regulation of allergic sensitization by stimulation of CD40 signaling." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 8, pp. 5138-44, (2006) (PubMed).

Honda, Yanai, Negishi, Asagiri, Sato, Mizutani, Shimada, Ohba, Takaoka, Yoshida, Taniguchi: "IRF-7 is the master regulator of type-I interferon-dependent immune responses." in: Nature, Vol. 434, Issue 7034, pp. 772-7, (2005) (PubMed).

Erlebacher, Zhang, Parlow, Glimcher: "Ovarian insufficiency and early pregnancy loss induced by activation of the innate immune system." in: The Journal of clinical investigation, Vol. 114, Issue 1, pp. 39-48, (2004) (PubMed).

McGregor, Schoenberger, Green: "CD154 is a negative regulator of autoaggressive CD8+ T cells in type 1 diabetes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 25, pp. 9345-50, (2004) (PubMed).

Turner, Rakhmilevich, Burdelya, Neal, Imboden, Sondel, Yu: "Anti-CD40 antibody induces antitumor and antimetastatic effects: the role of NK cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 1, pp. 89-94, (2001) (PubMed).

Mauri, Mars, Londei: "Therapeutic activity of agonistic monoclonal antibodies against CD40 in a chronic autoimmune inflammatory process." in: Nature medicine, Vol. 6, Issue 6, pp. 673-9, (2000) (PubMed).

Rolink, Andersson, Melchers: "Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity." in: European journal of immunology, Vol. 28, Issue 11, pp. 3738-48, (1998) (PubMed).
抗原

CD40

别名

CD40

背景

CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.

UniProt

P27512

途径

NF-kappaB Signaling, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints