TGFB1 抗体
(6 references)Quick Overview for TGFB1 抗体 (ABIN114558)
抗原
See all TGFB1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This antibody detects Transforming Growth Factor beta/TGF beta.
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纯化方法
- Affinity Chromatography on Protein G.
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免疫原
- TGF-beta from Human platelets.
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亚型
- IgG1
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anti-Transforming Growth Factor, beta 1 (TGFB1) (C-Term) antibody
TGFB1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Transforming Growth Factor, beta 1 (TGFB1) (AA 279-390) antibodyTGFB1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Transforming Growth Factor, beta 1 (TGFB1) (AA 62-195) antibodyTGFB1 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 7F6 unconjugated
anti-Transforming Growth Factor, beta 1 (TGFB1) (AA 351-390) antibodyTGFB1 适用: 人, 小鼠, 大鼠, 绵羊, 兔 WB, ELISA, FACS, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Transforming Growth Factor, beta 1 (TGFB1) (Middle Region) antibodyTGFB1 适用: 小鼠, 大鼠, Cow, Pig, 绵羊, 豚鼠, 犬, 马, 山羊 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Transforming Growth Factor, beta 1 (TGFB1) (AA 62-195) antibodyTGFB1 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal unconjugated
anti-Transforming Growth Factor, beta 1 (TGFB1) (AA 279-390) antibodyTGFB1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Transforming Growth Factor, beta 1 (TGFB1) (N-Term) antibodyTGFB1 适用: 人 WB, ELISA, FM 宿主: 兔 Polyclonal unconjugated
anti-Transforming Growth Factor, beta 1 (TGFB1) (C-Term) antibodyTGFB1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Transforming Growth Factor, beta 1 (TGFB1) (AA 279-390) antibodyTGFB1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal D11 unconjugated
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应用备注
- ELISAThis antibody recognizes both Human platelet-derived and recombinant TGF-beta in ELISA. Functional AssayThis antibody neutralizes TGF-beta activity in vitro, in an inhibition assay of CCL/64 cellgrowth and neutralizes the growth promoting action of TGF-beta in the NRK-49F colonyforming assay. The effect of micro-injection of this antibody into one blastomere of two cellstage Xenopus embryos indicated that it was able to neutralize effectively the bioactivity ofTGF-beta in vivo. Immunohistochemistry on FFPE and Frozen SectionsThis antibody has been used to demonstrate TGF-beta in ovine ovarian tissue and humanbreast carcinoma at a dilution of 1: 1000. As a consequence of the intense staining of theerythrocytes it is possible to locate a single cell within the ovarian stroma making it usefulin locating very fine capillary networks within tissue. Western Blotting5-20 ng/mL will allow visualization of 100 ng/lane of TGF-beta. Reacts with dimeric (25 Kd)
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限制
- 仅限研究用
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溶解方式
- Restore in 0.5 mL double distilled water.
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浓度
- 1.0 mg/mL
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缓冲液
- 0.01 M PBS, pH 7.0 without preservatives.
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储存液
- Without preservative
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注意事项
- This product is photosensitive and should be protected from light
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储存条件
- 4 °C
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储存方法
- Store the antibody at 2 - 8 °C. DO NOT FREEZE!
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: "Matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs) and transforming growth factor-? (TGF-?) in advanced canine myxomatous mitral valve disease." in: Research in veterinary science, Vol. 97, Issue 3, pp. 560-7, (2015) (PubMed).
: "The prevalence and nature of glycan alterations on specific proteins in pancreatic cancer patients revealed using antibody-lectin sandwich arrays." in: Molecular & cellular proteomics : MCP, Vol. 8, Issue 7, pp. 1697-707, (2009) (PubMed).
: "Atrial fibrillation down-regulates renal neutral endopeptidase expression and induces profibrotic pathways in the kidney." in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Vol. 10, Issue 10, pp. 1212-7, (2008) (PubMed).
: "Expression of transforming growth factor-beta1, -beta2 and -beta3 in normal and diseased canine mitral valves." in: Journal of comparative pathology, Vol. 139, Issue 2-3, pp. 97-107, (2008) (PubMed).
: "Gene expression signatures for tumor progression, tumor subtype, and tumor thickness in laser-microdissected melanoma tissues." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 13, Issue 3, pp. 806-15, (2007) (PubMed).
: "Tumor necrosis factor-alpha regulates the expression of inducible costimulator receptor ligand on CD34(+) progenitor cells during differentiation into antigen presenting cells." in: The Journal of biological chemistry, Vol. 276, Issue 49, pp. 45686-93, (2002) (PubMed).
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: "Matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs) and transforming growth factor-? (TGF-?) in advanced canine myxomatous mitral valve disease." in: Research in veterinary science, Vol. 97, Issue 3, pp. 560-7, (2015) (PubMed).
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- TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))
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别名
- TGFB1
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背景
- TGF beta 1 (Transforming Growth Factor Beta 1) is a multifunctional peptide capable of influencing cell proliferation, differentiation, and other functions in a wide range of cell types. Transformed as well as non neoplastic tissues, release transforming growth factors, and essentially all cells possess a specific TGF beta 1 receptor. The multimodal nature of TGF beta 1 is seen in its ability to stimulate or inhibit cellular proliferation. TGF beta 1 plays a fundamental role in tissue growth and differentiation involvement in adipogenesis, myogenesis, chondrogenesis, osteogenesis, epithelial cell differentiation and immune cell function. The C-terminal 112 amino acids constitute the mature protein.Synonyms: TGF-beta-1, TGFB, Transforming growth factor beta-1
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基因ID
- 7040
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NCBI登录号
- NP_000651
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UniProt
- P01137
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途径
- EGFR Signaling Pathway, Dopaminergic Neurogenesis, Cellular Response to Molecule of Bacterial Origin, Glycosaminoglycan Metabolic Process, Regulation of Leukocyte Mediated Immunity, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagy, Cancer Immune Checkpoints
抗原
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