alpha 2 Macroglobulin 抗体
Quick Overview for alpha 2 Macroglobulin 抗体 (ABIN113581)
抗原
See all alpha 2 Macroglobulin (A2M) 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects alpha-2-Macroglobulin.
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纯化方法
- Ammonium Sulphate fractionation
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免疫原
- Native Alpha-2 Macroglobulin
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应用备注
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Immunohistochemistry on frozen sections (1: 20 - 1: 200). ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 28.3 mg/mL
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缓冲液
- PBS, pH 7.2, 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))
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别名
- alpha-2-Macroglobulin
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背景
- Alpha 2 macroglobulin is a serum protein which is mainly synthesised in the liver. It functions as a broad range irreversible proteinase inhibitor that forms a "trap" around most proteases. Alpha 2 macroglobulin is a tetrameric molecule, and with a molecular weight of 720 kDa, it so large a molecule that it tends to remain intravascular. Following conformational change the proteinase is deposited within a central cavity where it is still active but prevented from further contact with its substrate. Removal of the complex is mediated by the generation of recognition sites which react with receptors on a variety of cells including macrophages and liver cells. Alpha 2 macroglobulin is localized on the surface of peripheral blood lymphocytes.Synonyms: A2M, Alpha 2 macroglobulin, Alpha-2-M, CPAMD5, PZP-like alpha-2-macroglobulin domain-containing
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基因ID
- 2
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NCBI登录号
- NP_000005
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UniProt
- P01023
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途径
- Lipid Metabolism
抗原
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