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BMI1 抗体

This anti-BMI1 antibody is a 小鼠 单克隆 antibody detecting BMI1 in WB, IHC, IHC (p) 和 ICC. Suitable for 小鼠.
产品编号 ABIN1112825
发货至: 中国

Quick Overview for BMI1 抗体 (ABIN1112825)

抗原

See all BMI1 抗体
BMI1 (BMI1 Polycomb Ring Finger Oncogene (BMI1))

适用

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小鼠

宿主

  • 79
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  • 6
小鼠

克隆类型

  • 79
  • 63
单克隆

标记

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This BMI1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

克隆位点

P9
  • 免疫原

    Recombinant Polycomb complex protein BMI-1 protein.

    亚型

    IgG2a
  • 应用备注

    WB (1:1000-5000), IHC-P (1:200), ICC (1:500). Other applications have not been tested. The optimal dilutions should be determined by end user.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    TBS (pH7.4), 0.5% BSA, 40% Glycerol and 0.05% Sodium Azide.

    储存液

    Sodium azide, Thimerosal (Merthiolate)

    储存条件

    4 °C/-20 °C

    储存方法

    Store at 4 °C after thawing (1 week). Aliquot and store at -20 °C for long term (at least one year). Avoid repeated freeze and thaw cycles.

    有效期

    12 months
  • 抗原

    BMI1 (BMI1 Polycomb Ring Finger Oncogene (BMI1))

    别名

    Polycomb complex protein BMI-1

    背景

    BMI1 has been reported as an oncogene by regulating p16 and p19, which are cell cycle inhibitor genes. BMI1 knockout in mice results in defects in hematopoiesis, skeletal patterning, neurological functions, and development of the cerebellum. It is a component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. BMI1 is necessary for efficient self-renewing cell divisions of adult hematopoietic stem cells as well as adult peripheral and central nervous system neural stem cells. BMI1 is also thought to inhibit ageing in neurons through the suppression of p53.

    途径

    Cell Division Cycle, Autophagy
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