F12 抗体 (Light Chain)
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北京 101111
Quick Overview for F12 抗体 (Light Chain) (ABIN111207)
抗原
See all F12 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- Light Chain
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特异性
- Reacts with the light chain of human Factor XII and at 100nM inhibits 50 % of Factor XII activity.
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纯化方法
- Protein G affinity chromatography
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免疫原
- Purified human Factor XII
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亚型
- IgG1
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anti-Coagulation Factor XII (F12) (AA 400-615) antibody
F12 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor XII (F12) (AA 352-587) antibodyF12 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor XII (F12) (C-Term) antibodyF12 适用: 人, 大鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor XII (F12) (AA 191-300) antibodyF12 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 3A3 unconjugated
anti-Coagulation Factor XII (F12) antibodyF12 适用: 人 ELISA, IHC, IP, IHC (p), IEP 宿主: 山羊 Polyclonal unconjugated
anti-Coagulation Factor XII (F12) (cleaved), (Internal Region) antibodyF12 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor XII (F12) (AA 486-600) antibodyF12 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor XII (F12) antibodyF12 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor XII (F12) (N-Term) antibodyF12 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA, to detect/quantitate Factor XII and in coagulation assays.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.95 mg/mL
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缓冲液
- PBS, pH 7.4, without preservative
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储存液
- Without preservative
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注意事项
- Aliquot to Avoid multiple freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- Upon receipt, store at -20 °C to -70 °C.
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- F12 (Coagulation Factor XII (F12))
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背景
- Coagulation factor XII circulates in blood as a zymogen. This single chain zymogen is converted to a two chain serine protease with an heavy chain (alpha factor XIIa) and a light chain. The heavy chain contains two fibronectin type domains, two epidermal growth factor (EGF) like domains, a kringle domain and a proline rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta factor XIIa light chain and the alpha factor XIIa light chain becomes beta factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha factor XIIa and then to beta factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in Factor XII gene do not cause any clinical symptoms and the sole effect is that whole blood clotting time is prolonged.Synonyms: HAF, Hageman factor
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基因ID
- 2161
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NCBI登录号
- NP_000496
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UniProt
- P00748
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途径
- Complement System
抗原
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