Fibrinogen 抗体
Quick Overview for Fibrinogen 抗体 (ABIN110984)
抗原
See all Fibrinogen 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- Gel filtration and anion exchange chromatography
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免疫原
- Purified human Fibrinogen
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亚型
- IgG1
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anti-Fibrinogen antibody
适用: 人, 大鼠 ELISA, IF (p), IHC (p), IHC (fro), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Fibrinogen antibody适用: 人 IF (p), IHC (p) 宿主: 小鼠 Monoclonal 4F7 unconjugated
anti-Fibrinogen antibody适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C7 unconjugated
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应用备注
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ELISA, RIA, westernblot (non-reducing conditions, in this application binds alpha-chain offibrinogen).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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溶解方式
- Restore with 0.5 mL sterile distilled water
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缓冲液
- 10 mM Sodium Phosphate, 0.15 M NaCl, pH 7.4, 0.01 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody at 2-8 °C for one month or (in small aliquots) at -20 °C for longer.
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- Fibrinogen
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背景
- Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/mL. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease. All these facts make fibrinogen an important parameter in the diagnosis of cardiovascular diseases.Synonyms: FGA, FGB, FGG
抗原
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