The antibody detects human TGF beta 1 (and has been used in sheep, see "Applications"). Other species not tested. In flow cytometry this antibody detects the intracellular form of TGF-beta (so-called latent, LAP-bound or inactive TGF-beta) as well as with membrane bound TGF-beta (extracellular matrix form). Western blotting demonstrated that this antibody reacts with the dimeric (25 kDa) and monomeric (12,5 kDa) forms of TGF-beta (active form) under both non-reducing and reducing conditions respectively. In ELISA the antibody recognizes both human platelet-derived and recombinant TGF-beta.
Transforming Growth Factor-Beta (TGF-beta, TGFB) was originally identified for its ability to induce phenotypic transformation of fibroblasts in diverse cell types. This protein controls proliferation, differentiation, and many other functions of various cell types. TGFB is present on most cell types including T cells and monocytes.Synonyms: TGF-beta-1, TGFB, Transforming growth factor beta-1