PAI1 抗体
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Quick Overview for PAI1 抗体 (ABIN1108976)
抗原
See all PAI1 (SERPINE1) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This antibody detects PAI-1. The epitope of the antibody does not cover the complete alpha-helix F and turn connecting alpha-helix F and beta-strand s3A, but is restricted to the hinge region between alpha-helix F and the main part of the PAI-1 Molecule. The monoclonal antibody MA-33H1F7 is a 'switching' antibody, capable of inducing a non-inhibitory substrate form of PAI-1. It was shown to inhibit PAI-1 in a dose dependent manner.
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交叉反应 （详细）
- Species reactivity (tested):Human, rat, mouse
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纯化方法
- Protein G
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亚型
- IgG1
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anti-Plasminogen Activator Inhibitor 1 (SERPINE1) antibody
SERPINE1 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 1D5 unconjugated
anti-Plasminogen Activator Inhibitor 1 (SERPINE1) antibodySERPINE1 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C6 unconjugated
anti-Plasminogen Activator Inhibitor 1 (SERPINE1) (AA 24-402) antibodySERPINE1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Plasminogen Activator Inhibitor 1 (SERPINE1) (Internal Region) antibodyVerified SERPINE1 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Plasminogen Activator Inhibitor 1 (SERPINE1) (AA 86-185) antibodySERPINE1 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 3F2 unconjugated
anti-Plasminogen Activator Inhibitor 1 (SERPINE1) antibodySERPINE1 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C4 unconjugated
anti-Plasminogen Activator Inhibitor 1 (SERPINE1) (AA 24-402) antibodySERPINE1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Plasminogen Activator Inhibitor 1 (SERPINE1) antibodySERPINE1 适用: 人, 猴 WB, IHC, FACS, IHC (p) 宿主: 小鼠 Monoclonal 6F3 unconjugated
anti-Plasminogen Activator Inhibitor 1 (SERPINE1) (AA 141-389) antibodySERPINE1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Plasminogen Activator Inhibitor 1 (SERPINE1) (AA 24-398) antibodySERPINE1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.1 % bovine serum albumin
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储存条件
- 4 °C
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储存方法
- Store at 2 - 8 °C.
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- PAI1 (SERPINE1) (Plasminogen Activator Inhibitor 1 (SERPINE1))
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别名
- SERPINE1 / PAI1
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背景
- Plasminogen activator inhibitor type-1 (PAI-1), a member of the serine protease inhibitor (serpin) superfamily, is an important protein in the regulation of fibrinolysis. PAI-1 is unique among the serpins because of its functional and conformational flexibility. PAI-1 is the most important physiological inhibitor of both tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA). Increased PAI-1 levels are associated with thrombotic events and is an established risk factor for cardiovascular diseases. The active conformation PAI-1 inhibits its target proteinases by the formation of a stable, inactive complex. Although PAI-1 is synthesized as an active molecule, it converts spontaneously to an inactive, latent form that can be partially reactivated by denaturing agents. In addition, a third conformation reacting as a non-inhibitory substrate towards various target proteinases has been identified. The epitope of monoclonal antibody MA-33H1F7 is predominantly composed of three residues (Lys154/Glu130/Arg131), positioned virtually linearly in the three-dimensional structure.Synonyms: Endothelial plasminogen activator inhibitor, PAI, PAI-1, PLANH1, Plasminogen Activator Inhibitor 1, Serpin E1
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基因ID
- 5054
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NCBI登录号
- NP_000593
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UniProt
- P05121
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途径
- p53 Pathway, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagy, Smooth Muscle Cell Migration
抗原
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