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Ly6g 抗体

Cited in 9+ publications. The 大鼠 单克隆 anti-Ly6g antibody (Clone NIMP-R14) (ABIN1108437) specifically detects Ly6g in FACS, IHC (fro), IHC (p), Func 和 EIA. The antibody is reactive with 小鼠 samples.
产品编号 ABIN1108437
发货至: 中国
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Quick Overview for Ly6g 抗体 (ABIN1108437)

抗原

Ly6g (Lymphocyte Antigen 6 Complex, Locus G (Ly6g))

适用

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小鼠

宿主

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大鼠

克隆类型

  • 100
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单克隆

标记

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This Ly6g antibody is un-conjugated

应用范围

  • 91
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Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Functional Studies (Func), Enzyme Immunoassay (EIA)

克隆位点

NIMP-R14
  • 交叉反应 (详细)

    Species reactivity (tested):Mouse.

    纯化方法

    Protein G Chromatography

    免疫原

    Purified BALB/c Mouse Neutrophils

    亚型

    IgG2b
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 浓度

    0.1 mg/mL

    缓冲液

    PBS, 0.1 % BSA

    储存条件

    4 °C

    储存方法

    Store undiluted at 2-8 °C.
  • Navarini, Lang, Verschoor, Recher, Zinkernagel, Nizet, Odermatt, Hengartner, Zinkernagel: "Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 17, pp. 7107-12, (2009) (PubMed).

    Nagendra, Schlueter: "Absence of cross-reactivity between murine Ly-6C and Ly-6G." in: Cytometry. Part A : the journal of the International Society for Analytical Cytology, Vol. 58, Issue 2, pp. 195-200, (2004) (PubMed).

    de Vries, Köhl, Leclercq, Wolfs, van Bijnen, Heeringa, Buurman: "Complement factor C5a mediates renal ischemia-reperfusion injury independent from neutrophils." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 7, pp. 3883-9, (2003) (PubMed).

    Tacchini-Cottier, Zweifel, Belkaid, Mukankundiye, Vasei, Launois, Milon, Louis: "An immunomodulatory function for neutrophils during the induction of a CD4+ Th2 response in BALB/c mice infected with Leishmania major." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 5, pp. 2628-36, (2000) (PubMed).

    Lubberts, Joosten, van Den Bersselaar, Helsen, Bakker, van Meurs, Graham, Richards, van Den Berg: "Adenoviral vector-mediated overexpression of IL-4 in the knee joint of mice with collagen-induced arthritis prevents cartilage destruction." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 8, pp. 4546-56, (1999) (PubMed).

    Van Lent, Blom, Holthuysen, Jacobs, Van De Putte, Van Den Berg: "Monocytes/macrophages rather than PMN are involved in early cartilage degradation in cationic immune complex arthritis in mice." in: Journal of leukocyte biology, Vol. 61, Issue 3, pp. 267-78, (1997) (PubMed).

    Fabrizi, Rizzuto, Nakase, Mita, Lomax, Grossman, Schon: "Sequence of a cDNA specifying subunit VIIa of human cytochrome c oxidase." in: Nucleic acids research, Vol. 17, Issue 17, pp. 7107, (1989) (PubMed).

    McLaren, Strath, Smithers: "Schistosoma mansoni: evidence that immunity in vaccinated and chronically infected CBA/Ca mice is sensitive to treatment with a monoclonal antibody that depletes cutaneous effector cells." in: Parasite immunology, Vol. 9, Issue 6, pp. 667-82, (1988) (PubMed).

    Lopez, Strath, Sanderson: "Differentiation antigens on mouse eosinophils and neutrophils identified by monoclonal antibodies." in: British journal of haematology, Vol. 57, Issue 3, pp. 489-94, (1984) (PubMed).

  • 抗原

    Ly6g (Lymphocyte Antigen 6 Complex, Locus G (Ly6g))

    别名

    Ly6G / GR1 Neutrophil Marker

    背景

    The Ly-6G/-6C locus encodes a family of Ly-6 proteins including Ly-6G and Ly-6C. Ly-6 antigens have a molecular weight between 15,000 and 18,000. Ly6G is together with Ly6c a component of the myeloid differentiation antigen Gr-1. Ly6G a GPI-anchored protein and is a good marker of peripheral neutrophils. Although predominantly presents on neutrophils, it is also expressed on a subset of eosinophils, differentiating pre-monocytes and plasmacytoid dendritic cells. Ly6C is a monocyte/macrophage and endothelial cell differentiation antigen regulated by interferon gamma, and may play a role in the development and maturation of lymphocytes. It is expressed on bone marrow cells, monocytes/macrophages, neutrophils, endothelial cells, and T cell subsets. Expression of Gr-1 in bone marrow correlates with granulocyte differentiation and maturation. However, the physiological role of Ly6G alone remains still unclear.Synonyms: Gr-1 Granulocyte marker

    基因ID

    10090

    UniProt

    P35461
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