MAPT 抗体 (pThr181)
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北京 101111
Quick Overview for MAPT 抗体 (pThr181) (ABIN1108154)
抗原
See all MAPT 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 177-187, pThr181
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序列
- Ala-Pro-Lys-Thr(p)-Pro-Pro-Ser-Ser-Gly-Glu-Cys
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse
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纯化方法
- Protein G affinity purified
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免疫原
- KLH conjugated with a short peptide corresponding to the amino acid sequence 177-187 on the phosphorylated Tau protein
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亚型
- IgG1
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anti-Microtubule-Associated Protein tau (MAPT) (AA 1-100) antibody
MAPT 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein tau (MAPT) (pSer262) antibodyMAPT 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein tau (MAPT) (pThr212) antibodyMAPT 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein tau (MAPT) (pSer235) antibodyMAPT 适用: 人, 大鼠, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein tau (MAPT) (AA 130-386) antibodyMAPT 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein tau (MAPT) (AA 34-368) antibodyMAPT 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein tau (MAPT) (pThr181) antibodyMAPT 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein tau (MAPT) (pThr205) antibodyMAPT 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein tau (MAPT) (pSer396) antibodyMAPT 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Microtubule-Associated Protein tau (MAPT) (pSer404) antibodyMAPT 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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溶解方式
- Double distillated water is recommended to reconstitute the antibody.
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缓冲液
- 0.01 M PBS pH 7.2
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C.
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- MAPT (Microtubule-Associated Protein tau (MAPT))
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别名
- MAPT / tau
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背景
- Tau is a neuronal microtubule associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerisation and stabilise microtubules, but it also serves to link certain signalling pathways to the cytoskeleton. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF) and neurofibrillary lesions in Alzheimer's disease (AD) brain. Hyperphosphorylation impairs the microtubule binding function of Tau, resulting in the destabilisation of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Hyperphosphorylated tau is also found in a range of other central nervous system disorders. Numerous serine/threonine kinases, including GSK3 beta, PKA, Cdk5, and casein kinase II can phosphorylate Tau.Synonyms: MAPTL, MTBT1, Microtubule-associated protein tau, Neurofibrillary tangle protein, PHF-tau, Paired helical filament-tau
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基因ID
- 9606
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UniProt
- P10636
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途径
- MAPK Pathway, Microtubule Dynamics, M Phase, Regulation of Cell Size
抗原
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