This antibody detects Junction plakoglobin at N-term. No cross reactivity with other proteins.
交叉反应 (详细)
Species reactivity (tested):Human, mouse, rat
纯化方法
Immunogen affinity purified
免疫原
Synthetic peptide corresponding to a sequence at the N-terminal of human Cateningamma .Remarks: Sequence is identical to the related mouse and rat sequence.
This product contains Sodium azide and Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
注意事项
Avoid repeated freezing and thawing.
储存条件
4 °C/-20 °C
储存方法
Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
抗原
JUP
(Junction Plakoglobin (JUP))
别名
Junction Plakoglobin
背景
Junction Plakoglobin (JUP) ,also knows as catenin gamma, is a major cytoplasmic protein that occurs in a soluble and a membrane-associated form and is the only known constituent common to the submembranous plaques of both kinds of adhering junctions, the desmosomes and the intermediate junctions. It is a component of the cadherin-catenin complex, which is predominantly localized where actin filaments anchor in adherens junctions of epithelial cells. The human plakoglobin gene localizes on chromosome 17q21. Gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin.Synonyms: CTNNG, Catenin gamma, DP3, Desmoplakin III, Desmoplakin-3, JUP