JUP 抗体 (N-Term)
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Quick Overview for JUP 抗体 (N-Term) (ABIN1107898)
抗原
See all JUP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- This antibody detects Junction plakoglobin at N-term. No cross reactivity with other proteins.
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交叉反应 (详细)
- Species reactivity (tested):Human, mouse, rat
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纯化方法
- Immunogen affinity purified
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免疫原
- Synthetic peptide corresponding to a sequence at the N-terminal of human Cateningamma .Remarks: Sequence is identical to the related mouse and rat sequence.
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亚型
- IgG
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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溶解方式
- 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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缓冲液
- 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3
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储存液
- Sodium azide, Thimerosal (Merthiolate)
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注意事项
- This product contains Sodium azide and Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- JUP (Junction Plakoglobin (JUP))
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别名
- Junction Plakoglobin
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背景
- Junction Plakoglobin (JUP) ,also knows as catenin gamma, is a major cytoplasmic protein that occurs in a soluble and a membrane-associated form and is the only known constituent common to the submembranous plaques of both kinds of adhering junctions, the desmosomes and the intermediate junctions. It is a component of the cadherin-catenin complex, which is predominantly localized where actin filaments anchor in adherens junctions of epithelial cells. The human plakoglobin gene localizes on chromosome 17q21. Gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin.Synonyms: CTNNG, Catenin gamma, DP3, Desmoplakin III, Desmoplakin-3, JUP
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基因ID
- 3728
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NCBI登录号
- NP_002221
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UniProt
- P14923
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途径
- Cell-Cell Junction Organization, Maintenance of Protein Location
抗原
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