Fibrinogen 抗体 (citrullinated)
Quick Overview for Fibrinogen 抗体 (citrullinated) (ABIN1107223)
抗原
See all Fibrinogen 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- citrullinated
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交叉反应 （详细）
- Species reactivity (tested):Human.
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纯化方法
- Purified
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亚型
- IgG2a
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anti-Fibrinogen antibody
适用: 人, 大鼠 ELISA, IF (p), IHC (p), IHC (fro), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Fibrinogen antibody适用: 人 IF (p), IHC (p) 宿主: 小鼠 Monoclonal 4F7 unconjugated
anti-Fibrinogen antibody适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C7 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL (when dissolved at 0.5 mg/mL, the BSA concentration will be 1%)
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缓冲液
- 10 mM Ammonium Bicarbonate buffer
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C . Add 0.05% Sodium Azide for longer storage.
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- Fibrinogen
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背景
- Fibrinogen is a protein produced by the liver which helps stop bleeding by helping blood clots to form. Fibrinogen gets deiminated (conversion from arginin to citrullin) by Peptidyl Arginine Deiminase (PAD) in inflamed joints in patients that develop rheumatoid arthritis.Citrulline, while being an amino acid, is not built into proteins during protein synthesis, as it is not coded for by DNA, yet several proteins are known to contain citrulline. These citrulline residues are generated by a family of enzymes called peptidylarginine deiminases (PADs), which convert arginine into citrulline in a process called citrullination or deimination. Proteins that normally contain citrulline residues include myelin basic protein (MBP), filaggrin, and several histone proteins, while other proteins, like fibrin and vimentin can get citrullinated during cell death and tissue inflammation. Patients with rheumatoid arthritis often (at least 80 % of them) develop an immune response against proteins containing citrulline. Although the origin of this immune response is not known, detection of antibodies reactive with citrulline containing proteins or peptides is now becoming an important help in the diagnosis of rheumatoid arthritis.Synonyms: FGA, FGB, FGG
抗原
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