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FAK 抗体 (AA 706-1052)

Name: FAK 抗体 (AA 706-1052)
SKU: ABIN1107179
Availability: OutOfStock

PTK2 适用: 人, 小鼠, 大鼠 WB, IF, IP 宿主: 小鼠 Monoclonal 12G4 unconjugated

产品编号 ABIN1107179

发货至: 中国

Datasheet as PDF

抗原 See all FAK (PTK2) 抗体

FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))
抗原表位
35

29

27

24

23

23

18

18

16

16

12

11

8

7

6

6

5

5

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1
AA 706-1052
适用
317

279

216

21

21

17

16

11

8

6

6

4

3

3

2

1

1

1

1

1
人, 小鼠, 大鼠
宿主
330

16

3

2

1

1
小鼠
Compatible Secondaries
克隆类型
324

29
单克隆
标记
169

19

16

13

13

13

13

13

13

13

10

9

9

9

9

9

2

1
This FAK antibody is un-conjugated
应用范围
292

125

122

121

107

70

68

48

31

26

22

5

2

2
Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

特异性

This antibody detects human, mouse and rat FAK in Western blotting, Immunoprecipitation and immunocytostaining. This antibody detects ~125 kDa of human FAK on Westernblotting with whole cell lysates from human cell line such as HeLa. Since active FAK is highly phosphorylated, position of FAK band on westernblotting may varry with its phosphorylation level.

交叉反应（详细）

Species reactivity (tested):Human, mouse, rat

纯化方法

Protein-A Sepharose

免疫原

GST fusion protein containing human FAK (residues 706-1052 a.a.)

克隆位点

12G4

亚型

IgG1

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anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (pTyr861) antibody
PTK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilution should be determined by the investigator.

限制

仅限研究用
缓冲液

PBS containing 50 % glycerol, without preservatives

储存液

Without preservative

注意事项

Avoid repeated freezing and thawing.

储存条件

-20 °C

储存方法

Store (in aliquots) at -20 °C.
抗原

FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))

别名

FAK1 / PTK2 (PTK2 产品)

别名

FADK antibody, FAK antibody, FAK1 antibody, FRNK antibody, PPP1R71 antibody, p125FAK antibody, pp125FAK antibody, PTK2 antibody, Fadk antibody, mKIAA4203 antibody, fak antibody, fak1a antibody, ptk2 antibody, ptk2a antibody, wu:fa18c04 antibody, zgc:66114 antibody, CG10023 antibody, CT28129 antibody, DFAK antibody, DFak antibody, DFak56 antibody, Dfak antibody, Dfak56 antibody, DmFAK antibody, Dmel\\CG10023 antibody, Fak56 antibody, Fak56D antibody, fak56 antibody, protein tyrosine kinase 2 antibody, protein tyrosine kinase 2 L homeolog antibody, PTK2 protein tyrosine kinase 2 antibody, protein tyrosine kinase 2ab antibody, Focal adhesion kinase antibody, PTK2 antibody, ptk2.L antibody, Ptk2 antibody, ptk2ab antibody, Fak antibody

背景

FAK (focal adhesion kinase) is a protein tyrosine kinase which colocalizes with integrin receptors at cell-substratum contact sites (focal adhesions). It is thought that enhanced tyrosine phosphorylation of FAK is important for integrin mediated signaling as well as for other signalings. FAK associates with a number of proteins such as Src, Shc, PI-3 kinase, Grb2, Cas, Cas-L, paxilin and transmamblane proteins, which enables FAK to couple to a variety of different intracellular transduction pathways in adherent and non-adherent cells. FAK is involved in anchorage-dependent survival signal through PI-3 kinase and also may play a role in cell growth, migration, cytoskeletal organization.Synonyms: FADK1, FAK, Focal adhesion kinase 1, Protein-tyrosine kinase 2, pp125FAK

基因ID

5747

NCBI登录号

NP_722560

UniProt

Q05397

途径

Response to Growth Hormone Stimulus, CXCR4-mediated Signaling Events, Smooth Muscle Cell Migration, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling