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CD73 抗体

This anti-CD73 antibody is a 小鼠 单克隆 antibody detecting CD73 in WB, IF, IP, IHC (fro) 和 Func. Suitable for 人.
产品编号 ABIN1106556
发货至: 中国

Quick Overview for CD73 抗体 (ABIN1106556)

抗原

See all CD73 (NT5E) 抗体
CD73 (NT5E) (5'-Nucleotidase, Ecto (CD73) (NT5E))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This CD73 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)

克隆位点

4G4
  • 交叉反应 (详细)

    Species reactivity (tested):Human.

    纯化方法

    Protein G Chromatography

    免疫原

    Inflamed synovial stroma from rheumatoid arthitis patients.

    亚型

    IgG1
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 浓度

    0.1 mg/mL

    缓冲液

    PBS, 0.1 % BSA

    储存条件

    4 °C

    储存方法

    Store undiluted at 2-8 °C.
  • 抗原

    CD73 (NT5E) (5'-Nucleotidase, Ecto (CD73) (NT5E))

    别名

    CD73

    背景

    CD73 is a 70- kDa GPI-anchored cell surface molecule and belongs to the 5'-nucleosidase family. CD73 is useful as marker for lymphocyte differentiation. It is abundantly expressed on the vascular endothelium and at a low level on certain subpopulations of human lymphocytes. Like many glycosyl-phosphatidylinositol (GPI)-anchored molecules, it transmits potent activation signals in T cells when ligated by antibodies. CD73 hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Ecto-5'-nucleotidase activity is an important mediator of the anti-inflammatory effect by converting extracellular AMP into a potent anti-inflammatory substance adenosine. CD73 has been shown to function as a co-stimulatory molecule in human T cells and to have a role in regulating lymphocyte adhesion. Triggering of CD73 on the surface of lymphocytes, but not on endothelial cells, results in the shedding of the CD73 and increased adhesion of lymphocytes to endothelium via LFA-1 clustering. Furthermore, CD73 has been implicated to mediate homing of skin-infiltrating lymphocytes in vivo. In B-cell chronic lymphocytic leukemia the expression of CD73 is decreased. Besides this, CD73 activity has been implicated as sensitive and useful indicator for mild zinc deficiency.Synonyms: 5'-nucleotidase, NT5, NT5E, NTE

    基因ID

    9606

    UniProt

    P21589

    途径

    Synaptic Membrane, Ribonucleoside Biosynthetic Process
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