CD51 抗体 (FITC)
Quick Overview for CD51 抗体 (FITC) (ABIN1106450)
抗原
See all CD51 (ITGAV) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- The monoclonal antibody BV3 recognizes human alpha-V/beta-3 integrin present on human cells.
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交叉反应 （详细）
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Species reactivity (tested):Human
Also reacts to: Beta-3 Integrin -
纯化方法
- Protein G
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亚型
- IgG1
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anti-Integrin alpha V (ITGAV) antibody
ITGAV 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Integrin alpha V (ITGAV) (C-Term) antibodyITGAV 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Integrin alpha V (ITGAV) (AA 560-744) antibodyITGAV 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Integrin alpha V (ITGAV) (AA 775-885) antibodyITGAV 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Integrin alpha V (ITGAV) (AA 51-150) antibodyITGAV 适用: 人, 小鼠 WB, FACS, ELISA, IHC (fro), IF (p), IF (cc), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Integrin alpha V (ITGAV) (AA 71-322) antibodyITGAV 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Integrin alpha V (ITGAV) antibodyITGAV 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Integrin alpha V (ITGAV) (AA 1-1048) antibodyITGAV 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Integrin alpha V (ITGAV) (AA 1-1048) antibodyITGAV 适用: 人 WB, PLA 宿主: 小鼠 Polyclonal unconjugated
anti-Integrin alpha V (ITGAV) (C-Term) antibodyITGAV 适用: 人, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.02 % sodium azide, 1 % bovine serum albumin
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store at 2 - 8 °C.
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- CD51 (ITGAV) (Integrin alpha V (ITGAV))
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别名
- CD51 / ITGAV
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背景
- Integrins are a superfamily of αβ heterodimeric cell-surface adhesion receptors found in many species. They are expressed on a variety of cells and mediate numerous physiological processes, including inflammation, migration, adhesion and proliferation. The β3 family consist of 2 members: αIIbβ3 and αvβ3, which mediate cell-cell and cell-ECM interactions and are important for cellular migration, regulation of gene expression, cell survival, adhesion and differentiation. All processes which are involved in tissue development, angiogenesis and thrombosis. Each subunit consist of an extracellular domain, a single transmembrane segment and a cytoplasmic tail. They connect to the actin cytoskeleton via adaptor proteins that bind theircytoplasmic tails. Cell matrix adhesions also act as signaling units by their capacity to organize the actin cytoskeleton and to accumulate various signaling intermediates. Integrin αvβ3 was originally identified as the vitronectin receptor. Nevertheless, other ligands include fibrinogen, fibronectin, laminin, thrombospondin, Von Willebrand factor, tenascin, osteopontin and several forms of collagen. The interactions of integrin αvβ3 to those ligands is mediated by the RGD (Arg-Gly-Asp) sequence motif present in these proteins. Deregulation of β3 integrins is involved in e.g. autoimmune diseases, cardiovascular disorders, transplant rejection and tumorigenesis. In contribution to the latter, integrin αvβ3 contribute by supporting growth of small (tumor) blood vessels thereby potentiating the metastatic potential. Overexpression of integrin αvβ3 has been demonstrated in various tumors and activated endothelium.Synonyms: Integrin alpha-V, MSK8, VNRA, Vitronectin receptor subunit alpha
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基因ID
- 3685
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NCBI登录号
- NP_001138472
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UniProt
- P06756
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途径
- Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Integrin Complex
抗原
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