MUC1 抗体
Quick Overview for MUC1 抗体 (ABIN1106104)
抗原
See all MUC1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This Mouse monoclonal antibody has been raised against Human milk-fat globule membranes (HMFGM) to obtain reagents for mammary tumor diagnosis. This monoclonal reacts towards an peptide epitope in the repeat region of MUC-1.
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交叉反应 (详细)
- Species reactivity (tested):Human.
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纯化方法
- Purified
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免疫原
- Deglycosylated purified MUC1 glycoprotein.
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亚型
- IgG1
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- MUC1 (Mucin 1 (MUC1))
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别名
- CD227 / Mucin-1 / MUC1
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背景
- Mucin 1, cell surface associated (MUC-1) or polymorphic epithelial mucin (PEM) is a mucin encoded by the MUC1 gene in humans. MUC-1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with colon, breast, ovarian, lung and pancreatic cancers.Synonyms: Breast carcinoma-associated antigen DF3, CA 15-3, Carcinoma-associated mucin, DF3, EMA, Episialin, H23AG, MUC-1, PEMT, PUM, Peanut-reactive urinary mucin, Polymorphic epithelial mucin, Tumor-associated epithelial membrane antigen, Tumor-associated mucin
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基因ID
- 4582
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NCBI登录号
- NP_001018016
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UniProt
- P15941
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途径
- Negative Regulation of intrinsic apoptotic Signaling
抗原
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