This antibody reacts with CD193 antigen. The antibody has also been reported to inhibit chemotactic migration of monocyte-derived DCs to RANTES (Ref.4). It suppresses the capacity of monocyte-derived DCs to stimulate allogenetic TCs proliferation and TCs derived IFN-γ secretion( Ref.4).
交叉反应 (详细)
Species reactivity (tested):Human
纯化方法
Protein A agarose
免疫原
Human CCR3 expressing transfectant (mouse pre-B cell lymphoma B300-19)
Optimal working dilution should be determined by the investigator.
限制
仅限研究用
状态
Liquid
缓冲液
50 tests in 1 mLvolume of 10 μM NaPB, 0.09 % NaN3, 1 % BSA
储存液
Sodium azide
注意事项
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
4 °C
储存方法
Store at 2 - 8 °C.
抗原
CCR3
(Chemokine (C-C Motif) Receptor 3 (CCR3))
别名
CD193 / CCR3
背景
Dendritic cells (DCs) are major antigen presenting cells (APCs) capable of stimulation resting T cells (TCs) in the primary immune response and are more potent APCs than peripheral blood monocytes or B cells. Several CC and CXC chemokines receptors were found to be expressed on some DCs and these molecules have been implicated to mediate in part the trafficking of DCs from blood to tissues and then to lymph nodes, where they form a close association with TCs in the process of antigen presentation. Recent studies have shown that CD191/CCR1 and CD193/CCR3 are potentially involved in antigen-presenting cell function of human DCs.Synonyms: C-C CKR-3, C-C chemokine receptor type 3, CC-CKR-3, CCR-3, CKR3, CMKBR3, Eosinophil eotaxin receptor