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CD40 Ligand 抗体 (N-Term)

This anti-CD40 Ligand antibody is a 兔 多克隆 antibody detecting CD40 Ligand in WB 和 IHC (p). Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN1105902
发货至: 中国

Quick Overview for CD40 Ligand 抗体 (N-Term) (ABIN1105902)

抗原

See all CD40 Ligand (CD40LG) 抗体
CD40 Ligand (CD40LG)

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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多克隆

标记

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This CD40 Ligand antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 抗原表位

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    N-Term

    特异性

    This antibody detects CD154 / CD40L at N-term. No cross reactivity with other proteins.

    交叉反应 (详细)

    Species reactivity (tested):Human, mouse, rat

    纯化方法

    Immunogen affinity purified

    免疫原

    Synthetic peptide corresponding to a sequence at the N-terminal of human CD40L .Remarks: Sequence is different from the relative sequence of mouse by two amino acids.

    亚型

    IgG
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 溶解方式

    0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    缓冲液

    50 % glycerol, 0.9 mg NaCl, 0.2 mg Na2HPO4

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • 抗原

    CD40 Ligand (CD40LG)

    别名

    CD154 / CD40L

    背景

    CD40 ligand(CD40L) is a type II membrane protein of 261 amino acids on activated T cells that induces B cell proliferation and immunoglobulin secretion. It has homology with tumour necrosis factor-alpha and -beta, and has important functions in B-cell activation and differentiation. Human CD40L with 5 exons, is mapped to the proximal region of the mouse X chromosome on Xq26.3-27.1, and can be detected on T cells but is absent from B cells and monocytes. Since CD40L is expressed on platelets and released from them on activation, its predictive value as a marker for clinical outcome and the therapeutic effect of inhibition of glycoprotein IIb /IIIa receptor in patients with acute coronary syndromes was investigated. The soluble CD40L may be involved in the process of restenosis and that it exerts its effect by triggering a complex group of inflammatory reactions on endothelial and mononuclear cells.CD40L plays a central role in the pathophysiology of acute coronary syndromes, and has a role in the pathogenesis of coronary artery lesions.Synonyms: CD40 ligand, CD40-L, CD40LG, GP39, T-cell antigen Gp39, TNF-related activation protein, TNFSF5, TRAP, Tumor necrosis factor ligand superfamily member 5

    基因ID

    959

    NCBI登录号

    NP_000065

    UniProt

    P29965

    途径

    NF-kappaB Signaling, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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