C1S 抗体
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北京 101111
Quick Overview for C1S 抗体 (ABIN1105612)
抗原
See all C1S 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Monoclonal antibody M81 reacts with an epitope on human C protein activated C1s, a subcomponent of the first component of C (C1). The epitope recognised by the antibody M81 is domain IV and/or V of the gamma-domain of activated C1s. It blocks C4 activation and C4 binding to activated C1s. The antibody reacts around the binding site of C1s and reacts with both active and inactive C1s.
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交叉反应 (详细)
- Species reactivity (tested):Human
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纯化方法
- Protein G
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亚型
- IgG1
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.1 % bovine serum albumin
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储存条件
- 4 °C
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储存方法
- Store at 2 - 8 °C.
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- C1S (Complement Component 1, S Subcomponent (C1S))
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别名
- C1s
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背景
- Activated C1s is a glycosylated single-polypeptide zymogen, MW 85 kD. Activation of the proenzyme C1s occurs through cleavage by the active form of C1r. The activated protease, activated C1s, consists of a disulfide-linked H chain and a L chain. Activated C1s is a serine protease and its catalytic site is located in the L chain. Activation of the classical C pathway is triggered by activated C1s which cleaves C4 and C2 to form the C3 convertase, C4bC2a.Synonyms: C1 esterase, Complement 1s, Complement C1s, Complement C1s subcomponent, Complement component 1 subcomponent s
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基因ID
- 716
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NCBI登录号
- NP_001725
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UniProt
- P09871
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途径
- Complement System
抗原
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