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CD59 抗体 (AA 31-111)

This anti-CD59 antibody is a 小鼠 单克隆 antibody detecting CD59 in FACS, IHC, ELISA 和 ICC. Suitable for 人. This Primary Antibody has been cited in 2+ publications.
产品编号 ABIN1098134
发货至: 中国

Quick Overview for CD59 抗体 (AA 31-111) (ABIN1098134)

抗原

See all CD59 抗体
CD59

适用

  • 170
  • 17
  • 13
  • 11
  • 5
  • 5
  • 5
  • 1
  • 1

宿主

  • 107
  • 94
  • 8
  • 6
小鼠

克隆类型

  • 117
  • 95
  • 1
单克隆

标记

  • 106
  • 26
  • 14
  • 13
  • 8
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This CD59 antibody is un-conjugated

应用范围

  • 106
  • 97
  • 85
  • 48
  • 46
  • 40
  • 32
  • 24
  • 16
  • 14
  • 13
  • 13
  • 11
  • 11
  • 11
  • 8
  • 3
  • 3
  • 3
  • 1
  • 1
  • 1
Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC)

克隆位点

8D2B8
  • 抗原表位

    • 16
    • 16
    • 10
    • 6
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 31-111

    原理

    CD59 Antibody

    纯化方法

    Purified antibody

    免疫原

    Purified recombinant fragment of human CD59 (AA: 31-111) expressed in E. Coli.

    亚型

    IgG1
  • 应用备注

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    ICC: 1/50 - 1/200

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified antibody in PBS with 0.05 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Alegretti, Mucenic, Merzoni, Faulhaber, Silla, Xavier: "Expression of CD55 and CD59 on peripheral blood cells from systemic lupus erythematosus (SLE) patients." in: Cellular immunology, Vol. 265, Issue 2, pp. 127-32, (2010) (PubMed).

    Ma, Chang, Qin, Sun, Huang, He: "Decreased expression of complement regulatory proteins, CD55 and CD59, on peripheral blood leucocytes in patients with type 2 diabetes and macrovascular diseases." in: Chinese medical journal, Vol. 122, Issue 18, pp. 2123-8, (2009) (PubMed).

  • 抗原

    CD59

    别名

    CD59

    背景

    This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

    分子量

    14.2 kDa

    基因ID

    966

    UniProt

    P13987

    途径

    Complement System
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