CD31 抗体
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北京 101111
Quick Overview for CD31 抗体 (ABIN108424)
抗原
See all CD31 (PECAM1) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- The antibody reacts with Mr 135 000 PECAM-1 polypeptide from leukocytes and endothelial cells. Detects all endothelial cells in breast. Shows erythroid differentiation in human leukemic cells.
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免疫原
- Monoclonal antibody to PECAM-1 is derived from the hybridoma produced by fusion between myeloma cells and Balb/c spleen cells. Ulex Europaeus-agglutinin-I reactive glycoproteins from cultured human umbilical vein endothelial cells isolated by lecitin-affinity chromatography were used as immunogen
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亚型
- IgG1
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应用备注
- No reactivity with paraffin sections. Working dilution in western blotting is at least 1:1000
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限制
- 仅限研究用
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储存条件
- 4 °C
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- CD31 (PECAM1) (Platelet/endothelial Cell Adhesion Molecule (PECAM1))
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别名
- PECAM-1
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背景
- PECAM-1 (CE6) monoclonal antibody against PECAM-1 was produced to characterize human leukemic cells. PECAM-1 is typically an antigen that is shared by both endothelial and distinct hematopoietic cells. It is widely expressed among leukocytes and functions as cell adhesion molecule for these cells. PECAM-1 reactivity can be interpreted as a further evidence for megakaryocytic nature of distinct cell lines has been shown. However, a new useful application for this monoclonal antibody appears to be its very high reactivity against human endothelial cells. A recent review article states that in contrast to other applied endothelial markers, for instance PAL-E monoclonal antibody to endothelial cells and antibodies to factor VIII-related antigen, CE6 monoclonal antibody, reacts with all endothelial cells in human breast.
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途径
- Regulation of Actin Filament Polymerization
抗原
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