(Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1))
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009].
Atsriku, Hoffmann, Moghaddam, Kumar, Surapaneni: "In vitro metabolism of a novel JNK inhibitor tanzisertib: interspecies differences in oxido-reduction and characterization of enzymes involved in metabolism." in: Xenobiotica; the fate of foreign compounds in biological systems, Vol. 45, Issue 6, pp. 465-80, (2015) (PubMed).
Aliases for AKR1B1 蛋白
aldo-keto reductase family 1 member B (AKR1B1) 蛋白 aldo-keto reductase family 1 member B (Akr1b1) 蛋白 aldo-keto reductase family 1, member B1 (aldose reductase) (AKR1B1) 蛋白 aldo-keto reductase family 1, member B1 (aldose reductase) S homeolog (akr1b1.S) 蛋白 aldo-keto reductase family 1, member B1 (aldose reductase) (akr1b1) 蛋白 ADR 蛋白 Akr1b3 蛋白 Akr1b4 蛋白 akr1b7 蛋白 ALDR1 蛋白 Aldr1 蛋白 ALDRED 蛋白 Alr 蛋白 ALR-P-I 蛋白 ALR2 蛋白 AR 蛋白 RATALDRED 蛋白 zgc:86611 蛋白