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Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. 再加上，我们可以发PACS2 抗体 (26)和数多这个蛋白质的别的产品。
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Missense Mutation in PACS2 gene is associated with Neurodevelopmental Disorders.
cIAPs constitutively downregulate PACS-2 by polyubiquitination and proteasomal degradation, thereby restraining TRAIL-induced killing of liver cancer cells
Tumor necrosis factor (显示 TNF 蛋白)-related apoptosis-inducing ligand (TRAIL) protein-induced lysosomal translocation of proapoptotic effectors is mediated by phosphofurin acidic cluster sorting protein-2.
subcellular localization and function of polycystin-2 (显示 PKD2 蛋白) are directed by phosphofurin acidic cluster sorting protein (PACS)-1 and PACS-2
PACS-2 as a novel sorting protein that links the endoplasmic reticulum (ER)-mitochondria axis to ER homeostasis
PACS-2 is required for Nef action and sorting of itinerant membrane cargo in the TGN (显示 TG 蛋白)/endosomal system
the phosphorylation state of the calnexin (显示 CANX 蛋白) cytosolic domain and its interaction with PACS-2 sort the chaperone between domains of the ER and the plasma membrane
Results identify PACS-2 as an essential TRAIL effector, and show that Akt (显示 AKT1 蛋白) cooperates with 14-3-3 (显示 YWHAQ 蛋白) to regulate the homeostatic and apoptotic properties of PACS-2 that mediate TRAIL action.
PACS-2 coordinates p53 (显示 TP53 蛋白)/p21- dependent cell cycle arrest with NF-kappaB (显示 NFKB1 蛋白)/Bcl-xL (显示 BCL2L1 蛋白)-dependent pro-survival signaling to support DNA repair in response to genotoxic damage.
CS-2 (显示 MYOZ1 蛋白) traffics to the nucleus where it regulates SIRT1 (显示 SIRT1 蛋白)-mediated p53 (显示 TP53 蛋白) deacetylation. PACS-2 binds SIRT1 (显示 SIRT1 蛋白) in vitro and directly inhibits SIRT1 (显示 SIRT1 蛋白)-catalyzed p53 (显示 TP53 蛋白) deacetylation.
Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.