anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) 抗体

Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, PTEN and DAXX. 再加上,我们可以发USP7 蛋白 (7)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
USP7 252870 Q6A4J8
USP7 7874 Q93009
USP7 360471 Q4VSI4
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Showing 10 out of 180 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 交付 价格 详细
Cow 非结合性 WB Host: Rat Target Name: USP7 Sample Tissue: Rat Brain Antibody Dilution: 1ug/ml WB Suggested Anti-USP7 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: A549 cell lysate 100 μL 2至3个工作日
小鼠 非结合性 FACS, IHC, IHC (p), WB 100 μL 11至14个工作日
小鼠 非结合性 IHC, IHC (p), WB 100 μL 11至14个工作日
非结合性 EIA, IHC (p), WB 0.4 mL 6至8个工作日
非结合性 EIA, WB USP7 Antibody (Center) western blot analysis in A2058 cell line lysates (35 µg/lane). This demonstrates the USP7 antibody detected the USP7 protein (arrow). 0.4 mL 6至8个工作日
Chimpanzee 非结合性 EIA, WB   0.1 mg 4至8个工作日
非结合性 ELISA, IHC, WB Western blot analysis of HAUSP/USP7 using anti-HAUSP/USP7 antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: human Hela whole cell lysates,  Lane 2: human 22RV1 whole cell lysates,  Lane 3: human A431 whole cell lysates,  Lane 4: human HepG2 whole cell lysates,  Lane 5: human HepG2 whole cell lysates,  Lane 6: human SGC-7901 whole cell lysates,  Lane 7: human A549 whole cell lysates,  Lane 8: rat brain tissue lysates, Lane 9: mouse testis tissue lysates. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-HAUSP/USP7 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for HAUSP/USP7 at approximately 140KD. The expected band size for HAUSP/USP7 is at 128KD. IHC analysis of HAUSP/USP7 using anti-HAUSP/USP7 antibody . HAUSP/USP7 was detected in paraffin-embedded section of human mammary cancer tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml rabbit anti-HAUSP/USP7 Antibody  overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC)(Catalog # SA1022) with DAB as the chromogen. 100 μg 4至6个工作日
非结合性 IF, IHC, WB Western blot analysis of extracts of various cell lines, using USP7 antibody (ABIN6293331) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s. Immunohistochemistry of paraffin-embedded human kidney cancer using USP7 antibody (ABIN6293331) at dilution of 1:200 (40x lens). 50 μL 11至13个工作日
非结合性 ELISA, IHC, IHC (p), WB Human Skeletal Muscle (formalin-fixed, paraffin-embedded) stained with USP7 antibody ABIN214390 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-USP7 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg 11至14个工作日
Bat 非结合性 WB 100 μL 11至14个工作日

引用最多的anti-USP7 抗体

  1. Human Polyclonal USP7 Primary Antibody for ICC, IF - ABIN151954 : Canning, Boutell, Parkinson, Everett: A RING finger ubiquitin ligase is protected from autocatalyzed ubiquitination and degradation by binding to ubiquitin-specific protease USP7. in The Journal of biological chemistry 2004 (PubMed)
    Show all 25 Pubmed References

  2. Human Monoclonal USP7 Primary Antibody for ELISA, WB - ABIN966249 : Abély: [Treatment of airway inflammation in cystic fibrosis]. in Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 2007 (PubMed)
    Show all 5 Pubmed References

  3. Human Monoclonal USP7 Primary Antibody for ELISA, WB - ABIN969186 : Becker, Marchenko, Maurice, Moll: Hyperubiquitylation of wild-type p53 contributes to cytoplasmic sequestration in neuroblastoma. in Cell death and differentiation 2007 (PubMed)
    Show all 3 Pubmed References

  4. Human Polyclonal USP7 Primary Antibody for IHC (p), ELISA - ABIN545112 : DAndrea, Pellman: Deubiquitinating enzymes: a new class of biological regulators. in Critical reviews in biochemistry and molecular biology 1999 (PubMed)
    Show all 3 Pubmed References

  5. Human Monoclonal USP7 Primary Antibody for EIA, WB - ABIN1109455 : Lu, Ma, Nguyen, Jones, Oren, Donehower: The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop. in Cancer cell 2007 (PubMed)
    Show all 3 Pubmed References

  6. Cow (Bovine) Polyclonal USP7 Primary Antibody for WB - ABIN2787924 : Nie, Zhang, Dai, Zhang, Zhao, Xu, Chen, Wang, Wang, Qiao: Nicotine Induced Murine Spermatozoa Apoptosis via Up-Regulation of Deubiquitinated RIP1 by Trim27 Promoter Hypomethylation. in Biology of reproduction 2016 (PubMed)


Fruit Fly (Drosophila melanogaster) Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) interaction partners

  1. Usp7 regulates Hippo pathway through deubiquitinating the transcriptional coactivator Yorkie. Hippo pathway attenuates the binding of a ubiquitin-specific protease Usp7 to Yki, which regulates Hippo signaling through deubiquitinating Yki.

  2. reveal a conserved mechanism by which Ci/Gli is stabilized by a deubiquitination enzyme and identify Usp7/HUASP as a critical regulator of Hh signaling and potential therapeutic target for Hh-related cancers

  3. Genetic and gene expression analyses suggested that GMPS/USP7 acts as a transcriptional corepressor

  4. GMP synthetase stimulates histone H2B deubiquitylation by the epigenetic silencer USP7

Mouse (Murine) Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) interaction partners

  1. Evidence shows that USP7 localizes to replication foci independently of DNMT1 and indicates that USP7 does not control cell cycle-dependent levels of DNMT1.

  2. Pit1 deletion inhibited USP7/IRS1 dissociation upon insulin stimulation.

  3. EPOP (E130012A19Rik) interacts with elongin B, elongin C, and USP7 to modulate the chromatin landscape.

  4. USP7 is overexpressed and regulates homologous recombination repair in chronic lymphocytic leukemia cells.

  5. Findings demonstrate a crucial role of HAUSP in regulating N-Myc function in neuroblastoma in vivo and suggest that HAUSP inhibition is a potential therapy for MYCN-amplified tumors.

  6. The present study identified USP7 and TDP-43 as the regulators of CRY1 and CRY2, underscoring the significance of the stability control process of CRY proteins for period determination in the mammalian circadian clockwork.

  7. demonstrate that genotoxic stress stimulates Cry1 phosphorylation and its deubiquitination by Herpes virus associated ubiquitin-specific protease (Hausp, a.k.a Usp7), stabilizing Cry1 and shifting circadian clock time

  8. Our results demonstrate that the SCML2/USP7 complex constitutes a novel molecular pathway in modulating the epigenetic state of sex chromosomes during male meiosis

  9. USP7-mediated mono-deubiquitination of FoxO1 results in suppression of FoxO1 transcriptional activity through decreased FoxO1 occupancy on the promoters of gluconeogenic genes.

  10. Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60.

  11. The ubiquitination-deubiquitination cascade mediated by the TRIM27-USP7 complex plays an important role in TNF-alpha-induced apoptosis.

  12. the stability and activity of PPARgamma2 are modulated by the deubiquitinating activity of HAUSP, which may be a target for the development of anti-diabetic drugs.

  13. data reveal a molecular mechanism in which rapid temporal control of Foxp3 expression in Treg cells can be regulated by USP7, thereby modulating Treg cell numbers and function

  14. These results indicate that HAUSP-mediated p53 regulation is crucial for brain development, and also suggest that both the p53-dependent and the p53-independent functions of HAUSP contribute to the neonatal lethality of hausp-mutant mice.

  15. HAUSP knockout mice embryos showed p53 activation, but no increase in apoptosis.

  16. USP7 (HAUSP) is proteolytically processed upon dexamethasone-, gamma-irradiation-, and antigen-induced cell death. Such processing of HAUSP does not occur in caspase 3-/- thymocytes.

  17. mHAUSP functions as a deubiquitinating enzyme for p53

  18. mHAUSP regulates apoptosis of cervical adenocarcinoma cells

Human Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) interaction partners

  1. FAM188B is a putative oncogene that functions via interaction with USP7.

  2. Targeting HAUSP as an anti-cancer strategy in both p53 wildtype and p53-mutant tumors has been described.

  3. study reveals a role for USP7 in regulating the function of the MRN-MDC1 complex and activity of the DDR, supporting the pursuit of USP7 as a potential therapeutic target for MDC1-proficient cancers.

  4. High USP7 expression is associated with esophageal squamous cell carcinoma.

  5. The identification of two clusters of patients based on CCDC6 and USP7 expession can possibly indicate the use of PARP-inhibitor drugs.

  6. these data reveal a new post-transcriptional role for USP47 and USP7 in inflammation by regulating inflammasome activation and the release of the pro-inflammatory cytokines IL-1beta and IL-18, and implicate dual USP7 and USP47 inhibitors as potential therapeutic agents for inflammatory disease.

  7. The USP7 efficiently removes polyubiquitin chains from polyubiquitinated PCNA by preferential cleavage of the PCNA-ubiquitin linkage.

  8. The level of USP7 protein was higher in multiple myeloma cell lines and bortezomib-resistant cell lines than in BM mononuclear cells from healthy donors. There was a statistically significant inverse correlation between USP7 levels and overall survival. USP7 plays a role in the pathogenesis of multiple myeloma, and high expression of USP7 is a poor prognostic marker for MM patients.

  9. Exo-circ-DB promotes HCC growth and reduces DNA damage via the suppression of miR-34a and the activation of deubiquitination-related USP7.

  10. findings suggest that USP7 acts as a negative regulator in antiviral signaling by stabilizing TRIM27 and promoting the degradation of TBK1.

  11. Using NMR analysis and biochemistry study describes the order of activation steps, showing that ubiquitin binding is an instrumental step in USP7 activation.

  12. Study demonstrated that USP7 expression in osteosarcoma (OS) tumor tissues was markedly higher than that in the paired surrounding tissues, and high USP7 expression was positively correlated with the TNM stage and metastasis in patients with OS.

  13. The deubiquitination activity of USP7 was inhibited by the ubiquitin-conjugating enzyme UbcH6. UVSSA deficient in the interaction with USP7 is ubiquitinated and degraded by the proteasome.

  14. Full kinetic analysis and multiple X-ray crystal structures indicate that electrostatic interactions in the distal ''switching loop'' region and local packing in the hydrophobic core mediate subtle but significant conformational changes that modulate USP7 activation.

  15. show that BRE facilitates deubiquitylation of CDC25A by recruiting ubiquitin-specific-processing protease 7 (USP7) in the presence of DNA damage

  16. High expression of USP7 is frequent in HCC tissues, which promotes tumor proliferation and invasion, and is correlated with a poor overall survival.

  17. REVIEW: USP7 plays crucial roles in diverse array of cellular and biological processes including tumour suppression, cell cycle, DNA repair, chromatin remodelling, and epigenetic regulation.

  18. USP7 depletion in APC-mutated colorectal cancer inhibits Wnt activation by restoring beta-catenin ubiquitination, drives differentiation, and suppresses xenograft tumor growth.

  19. USP7 is RNF169 interacting protein.Expression of USP7 and RNF169 positively correlated in breast cancer.

  20. protein deubiquitinase USP7 is an essential player in osteogenic differentiation of Human adipose-derived stem cells.

USP7 抗原简介


Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Involved in transcription-coupled recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6 (By similarity).

Gene names and symbols associated with USP7

  • Ubiquitin-specific protease 7 (Usp7) 抗体
  • ubiquitin carboxyl-terminal hydrolase 7 (LOC100201254) 抗体
  • ubiquitin specific peptidase 7 (USP7) 抗体
  • ubiquitin specific peptidase 7 (Usp7) 抗体
  • 2210010O09Rik 抗体
  • AA409944 抗体
  • AA617399 抗体
  • AU019296 抗体
  • AW548146 抗体
  • C80752 抗体
  • CG1490 抗体
  • Dmel\\CG1490 抗体
  • HAUSP 抗体
  • TEF1 抗体
  • UBP 抗体
  • USP7 抗体

Protein level used designations for USP7

CG1490-PB , Usp7-PB , ubiquitin specific peptidase 7 (herpes virus-associated) , ubiquitin carboxyl-terminal hydrolase 7-like , deubiquitinating enzyme 7 , herpesvirus-associated ubiquitin-specific protease , mHAUSP , ubiquitin carboxyl-terminal hydrolase 7 , ubiquitin specific protease 7 , ubiquitin thioesterase 7 , ubiquitin thiolesterase 7 , ubiquitin-specific-processing protease 7 , Herpes virus-associated ubiquitin-specific protease , ubiquitin specific protease 7 (herpes virus-associated) , herpes-virus-associated ubiquitin-specific protease , rHAUSP , ubiquitin-specific peptidase 7

32169 Drosophila melanogaster
100201254 Hydra magnipapillata
100468835 Ailuropoda melanoleuca
252870 Mus musculus
7874 Homo sapiens
360471 Rattus norvegicus
395126 Gallus gallus
479854 Canis lupus familiaris
100190899 Sus scrofa
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