anti-Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) 抗体

The protein encoded by TRPC6 forms a receptor-activated calcium channel in the cell membrane. 再加上,我们可以发Transient Receptor Potential Cation Channel, Subfamily C, Member 6 蛋白 (8)Transient Receptor Potential Cation Channel, Subfamily C, Member 6 试剂盒 (6)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
TRPC6 7225 Q9Y210
TRPC6 22068 Q61143
TRPC6 89823  
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产品编号 适用 宿主 标记 应用范围 图像 规格 交付 价格 详细
非结合性 IHC (p), WB Anti-TRPC6 antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue Anti-TRPC6 antibody, Western blotting Lane 1: Rat Lung Tissue Lysate Lane 2: 293T Cell Lysate Lane 3: 293T Cell Lysate 100 μg 4至6个工作日
非结合性 WB WB Suggested Anti-TRPC6 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: MCF7 cell lysate 100 μL 2至3个工作日
Cow 非结合性 WB WB Suggested Anti-TRPC6 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  MCF7 cell lysate TRPC6 antibody - middle region  validated by WB using pulmonary artery smooth muscle 100 μL 2至3个工作日
山羊 非结合性 ELISA, WB ABIN334518 (0.03 ug/ml) staining of Human Placenta lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg 6至7个工作日
小鼠 非结合性 WB Western blot analysis of TRPC6 using anti-TRPC6 antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: rat ovary tissue lysate, Lane 2: mouse lung tissue lysate.  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-TRPC6 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for TRPC6 at approximately 106KD. The expected band size for TRPC6 is at 106KD. 100 μg 4至6个工作日
小鼠 山羊 非结合性 ELISA, FACS   100 μg 6至7个工作日
小鼠 非结合性 IHC, ELISA, WB Immunohistochemistry using  anti-TRPC6 monoclonal antibody shows detection of TRPC6 in human adrenal (cortex) tissue (40X). The antibody was used a dilution to 2.5 µg/mL. The image shows strong staining with minimal background staining. Tissue was formalin fixed and paraffin embedded. No pre-treatment of sample was required. The image shows the localization of antibody as the precipitated red signal, with a hematoxylin purple nuclear counterstain. Personal communication, Andrew Elston, Lifespan Biosciences, Seattle, WA. Western Blot of Mouse anti-TRPC6 Antibody Lane 1: Mouse Kidney WCL Load: 10 µg per lane Primary antibody: TRPC6 Antibody at 1:1000 for overnight at 4°C Secondary antibody: 649 donkey anti-mouse at 1:20,000 for 30 min at RT Block: ABIN925618 for 30 min at RT 100 μg 5至7个工作日
非结合性 IHC, WB WB Suggested Anti-TRPC6 Antibody Titration:  2.5ug/ml  Positive Control:  HepG2 cell lysate Human kidney 100 μL 2至3个工作日
山羊 非结合性 ELISA, IHC   100 μg 6至7个工作日
非结合性 WB WB Image A549 whole cell and membrane extracts (30 μg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with TRPC6 antibody , diluted at 1:3000. WB Image Sample(30 μg of whole cell lysate) A:HeLa S3, 7.5% SDS PAGE antibody diluted at 1:3000 100 μL 3至4个工作日

引用最多的anti-Transient Receptor Potential Cation Channel, Subfamily C, Member 6 抗体

  1. Human Polyclonal TRPC6 Primary Antibody for IP, ELISA - ABIN314245 : Foller, Kasinathan, Koka, Lang, Shumilina, Birnbaumer, Lang, Huber: TRPC6 contributes to the Ca(2+) leak of human erythrocytes. in Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2008 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal TRPC6 Primary Antibody for IHC (p), WB - ABIN541554 : Dietrich, Kalwa, Rost, Gudermann: The diacylgylcerol-sensitive TRPC3/6/7 subfamily of cation channels: functional characterization and physiological relevance. in Pflügers Archiv : European journal of physiology 2005 (PubMed)
    Show all 4 Pubmed References

  3. Human Polyclonal TRPC6 Primary Antibody for IHC (p), WB - ABIN541555 : Montell, Birnbaumer, Flockerzi, Bindels, Bruford, Caterina, Clapham, Harteneck, Heller, Julius, Kojima, Mori, Penner, Prawitt, Scharenberg, Schultz, Shimizu, Zhu: A unified nomenclature for the superfamily of TRP cation channels. in Molecular cell 2002 (PubMed)
    Show all 3 Pubmed References

  4. Human Polyclonal TRPC6 Primary Antibody for EIA, IHC (p) - ABIN5555390 : Wajdner, Farrington, Barnard, Peachell, Schnackenberg, Marino, Xu, Affleck, Begg, Seward: Orai and TRPC channel characterization in FcεRI-mediated calcium signaling and mediator secretion in human mast cells. in Physiological reports 2017 (PubMed)

  5. Mouse (Murine) Polyclonal TRPC6 Primary Antibody for FACS, ELISA - ABIN269792 : Winn, Conlon, Lynn, Farrington, Creazzo, Hawkins, Daskalakis, Kwan, Ebersviller, Burchette, Pericak-Vance, Howell, Vance, Rosenberg: A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. in Science (New York, N.Y.) 2005 (PubMed)

  6. Human Monoclonal TRPC6 Primary Antibody for IHC, ELISA - ABIN964697 : Alonso-González, Cabo, San José, Gago, Suazo, García-Suárez, Cobo, Vega: Human Digital Meissner Corpuscles Display Immunoreactivity for the Multifunctional Ion Channels Trpc6 and Trpv4. in Anatomical record (Hoboken, N.J. : 2007) 2018 (PubMed)

  7. Human Polyclonal TRPC6 Primary Antibody for IHC (p), WB - ABIN3044146 : Wang, Wang, Li: TRPC1/TRPC3 channels mediate lysophosphatidylcholine-induced apoptosis in cultured human coronary artery smooth muscles cells. in Oncotarget 2018 (PubMed)

更多抗Transient Receptor Potential Cation Channel, Subfamily C, Member 6的相互作用对抗体

Human Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) interaction partners

  1. TRPC6 expression is inversely correlated with cognitive performance of Alzheimer Disease (AD). TRPC6 in peripheral leucocytes may be a potential biomarker for the diagnosis of AD.

  2. Findings indicate that OLCT impairs the ability of breast cancer cells to proliferate and migrate via downregulation of TRPC6 channel expression while having no effect on the biology of non-tumoral breast cells.

  3. TRPC6 plays a pro-inflammatory role in the pathogenesis of CRSwNP via regulating Ca(2+) flow. Targeted therapy using TRPC6 inhibitor including SKF-96365 and TRPC6 small interfering RNA (siRNA) intranasally may alleviate the inflammatory reaction in CRSwNP.

  4. data demonstrate that the direct activation of TRPC6 channels contributes to CNCP-induced apoptotic cell death in HK-2cells

  5. Four novel TRPC6 variants were detected in Iranian focal segmental glomerulosclerosis children; in silico analysis showed that 2 variants (D130V and G162R) could be pathogenic.

  6. Authors found a specific reduction of TRPC6 mRNA levels in four AD sets and one MCI set. The median TRPC6 mRNA levels were lower in the following: (1) combined AD patients than in age-matched controls (0.78 vs 1.73, P<0.001); (2) mild-to-moderate AD patients than in age-matched controls (0.81 vs 1.73, P<0.001); and (3) MCI patients than in age-matched controls (0.76 vs 1.72, P<0.001).

  7. The results strongly suggest that Nox2 destabilization through disrupting TRPC3-Nox2 complex underlies attenuation of hyperglycemia-induced heart failure by TRPC6.

  8. The underlying mechanism forAT1-autoantibody induced podocyte damage might involve activation of the TRPC6 -calcium/calcineurin pathway.

  9. TRPC6 was upregulated in Diabetic nephropathy and could promote cell proliferation and inflammation by inhibiting the NFAT signaling pathway in tubular epithelial cells.

  10. Changes in podocyte TRPC channels evoked by plasma and sera from patients with recurrent FSGS and by putative glomerular permeability factors.

  11. Confirmed serine 14 as a target of MAPKs and proline-directed kinases like cyclin-dependent kinase 5 (Cdk5) in cell-based as well as in vitro kinase assays and quantitative phosphoproteomic analysis of TRPC6. Phosphorylation of TRPC6 at serine 14 enhances channel conductance by boosting membrane expression of TRPC6, whereas protein stability and multimerization of TRPC6 are not altered.

  12. Reduction of TRPC6 activity, using either TRPC6 siRNA or a TRPC6 blocker, led to inhibition of hypoxia-induced autophagy, while enhancement of TRPC6 activity with a TRPC6 activator resulted in increased hypoxia-induced autophagy.

  13. axonal colocalization of TRPV4 and TRPC6 was found in the digital Meissner corpuscles

  14. Data suggest that TRPC6-mediated elevation of intracellular Ca2+ stimulates non-small cell lung cancer proliferation by promoting cell cycle progression.

  15. potential implications of transient receptor potential (TRP) channels in the pathogenesis of intestinal fibrosis, since they are known to act as cellular stress sensors/transducers affecting intracellular Ca(2+) homeostasis/dynamics, and are involved in a broad spectrum of cell pathophysiology including inflammation and tissue remodeling.

  16. Studies provide evidence that the TRPC6-mediated signaling pathway in kidney cells is under control of reactive oxygen species under both physiological and pathological conditions. [review]

  17. SARAF modulates TRPC1, but not TRPC6, channel function in a STIM1-independent manner

  18. Functional interaction of upregulated CaSR and upregulated TRPC6 in pulmonary artery smooth muscle cells from idiopathic pulmonary arterial hypertension patients may play an important role in the development and progression of sustained pulmonary vasoconstriction and pulmonary vascular remodeling.

  19. Our comprehensive analysis of human disease-causing TRPC6 mutations reveals loss of TRPC6 function as an additional concept of hereditary focal segmental glomerulosclerosis and provides molecular insights into the mechanism responsible for the loss-of-function phenotype of TRPC6 G757D in humans

  20. study demonstrated that the various mechanisms regulating MDR in HCC cells are calcium dependent through the TRPC6/calcium/STAT3 pathway. We propose that targeting TRPC6 in HCC may be a novel antineoplastic strategy, especially combined with chemotherapy

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) interaction partners

  1. results together suggested that miR-200b-3p inhibition reduced the currents of TRPC6, which led to the decrease of intracellular Ca(2+) concentration

  2. Trpc3 mRNA expression was significantly elevated in kidneys of Trpc6(-/-) mice underwent unilateral ureteral obstruction (UUO) while the levels did not change in kidneys of neither WT nor in New Zealand obese mice underwent UUO.

  3. This work indicates that TRPC6 exerts critical pathophysiological functions in placenta, and provides further evidence for a role of this channel in the homeostasis of cations like Zn and Fe.

  4. structure of the cytoplasmic domain of murine transient receptor potential cation channel subfamily C member 6

  5. These results suggest that TRPC6 may regulate GFR by modulating MC contractile function through multiple Ca(2+) signaling pathways.

  6. TRPC6-/- mice show less collagen production and normal lung function in pulmonary fibrosis compared to wild-type controls. TRPC6 expression is up-regulated in TGF-beta1-induced lung fibroblast-myofibroblast transdifferentiation.

  7. We conclude that TRPC6 channels of pancreatic stellate cells are major effector proteins in an autocrine stimulation pathway triggered by hypoxia.

  8. findings link Trpc6-mediated Ca2+ signaling and nitrosative stress in the redox pathobiology of Duchenne muscular dystrophy

  9. The injury phase after myocardial infarcts occurs during reperfusion and is a consequence of calcium release from internal stores combined with calcium entry, leading to cell death. We identify canonical transient receptor potential channels (TRPC) 3/6/7 as the cation channels through which most of the damaging calcium enters cells to trigger their death, and we describe mechanisms activated during the injury phase.

  10. Administration of soluble klotho significantly reduced obstruction-induced renal fibrosis in wild-type mice, but not in Trpc6 knockout mice, indicating that klotho and TRPC6 inhibition act in the same pathway to protect against obstruction-induced renal fibrosis.

  11. In the present study, we have explored the hypothesis that TRPC3 and TRPC6 channels expressed in VSMCs may have a differential contribution to the regulation of vascular tone, which could be relevant for the changes in vascular reactivity associated with essential hypertension

  12. This study demonstrated that Transient Receptor Potential Canonical 6 (TRPC6) and Orai2 form stromal interaction molecule 2 (STIM2)-regulated neuronal-store-operated Ca(2+) influx (nSOC) channel complex in hippocampal synapse and the resulting Ca(2+) influx is critical for long-term maintenance of mushroom spines in hippocampal neurons.

  13. ASIV may prevent HG-induced podocyte apoptosis via downregulation of TRPC6, which is possibly mediated via the calcineurin/NFAT signaling pathway.

  14. the mTORC2/Akt/NFkappaB pathway-mediated activation of TRPC6 participates in adriamycin-induced podocyte apoptosis.

  15. AngII-injured podocyte had a significant increase in apoptosis, while silencing TRPC6 could decrease the apoptosis induced by AngII.

  16. transient receptor potential canonical 6 is an essential component of the slit diaphragm and is required for development of glomerulus

  17. TRPC3 and TRPC6 participate diversely in synaptic reorganization in the mossy fiber pathway in temporal lobe epilepsy.

  18. the transient receptor potential canonical-6 (TRPC6) calcium-permeable channel in the alveolar macrophages also functions to shunt the transmembrane potential generated by proton pumping.

  19. Selectively activating endothelial TRPC6 rescues transendothelial migration

  20. MicroRNA-26a prevents endothelial cell apoptosis by directly targeting TRPC6 in the setting of atherosclerosis.

Cow (Bovine) Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) interaction partners

  1. These findings suggest that lysoPC induces CaM phosphorylation at Tyr(99) by a Src family kinase and that phosphorylated CaM activates PI3K to produce PIP3, which promotes TRPC6 translocation to the cell membrane.

  2. analysis of a TRPC6-TRPC5 channel cascade that restricts endothelial cell movement

Pig (Porcine) Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) interaction partners

  1. Hyperforin (HF)-induced TRPC6 channel activation increased [Ca(2+)]i concentration, inhibited proliferation, and triggered apoptosis in primary neonatal pig glomerular mesangial cells. This apoptosis was not associated with oxidative stress. Activation stimulated NFATc1 nuclear translocation. HF also increased FasL level and caspase-8 activity.

  2. Data found that the pig adrenal medulla expressed predominantly TRPC1, TRPC5, and TRPC6 transcripts. The expression level of these TRPCs was significantly elevated in the adrenal medulla from pigs with metabolic syndrome.

Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) 抗原简介


The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2).

Gene names and symbols associated with TRPC6

  • transient receptor potential cation channel subfamily C member 6 (TRPC6) 抗体
  • transient receptor potential cation channel, subfamily C, member 6 (Trpc6) 抗体
  • transient receptor potential cation channel, subfamily C, member 6a (trpc6a) 抗体
  • transient receptor potential cation channel subfamily C member 6 (Trpc6) 抗体
  • transient receptor potential cation channel subfamily C member 6 (trpc6) 抗体
  • AV025995 抗体
  • bZ1P14.9 抗体
  • FSGS2 抗体
  • LLHWJM002 抗体
  • LLHWJM003 抗体
  • LLHWJM004 抗体
  • mtrp6 抗体
  • si:rp71-1p14.9 抗体
  • TRP-6 抗体
  • trp6 抗体
  • trpc6 抗体
  • Trrp6 抗体

Protein level used designations for TRPC6

TRP-6 , short transient receptor potential channel 6 , transient receptor protein 6 , calcium entry channel , transient receptor potential cation channel, subfamily C, member 6 , transient receptor potential channel subfamily C member 6 , short transient receptor potential channel 6-like

7225 Homo sapiens
22068 Mus musculus
89823 Rattus norvegicus
407151 Bos taurus
418989 Gallus gallus
451503 Pan troglodytes
489435 Canis lupus familiaris
563989 Danio rerio
100061175 Equus caballus
100079408 Ornithorhynchus anatinus
100135637 Cavia porcellus
100271728 Sus scrofa
100347206 Oryctolagus cuniculus
100395510 Callithrix jacchus
100479387 Ailuropoda melanoleuca
100545253 Meleagris gallopavo
100554810 Anolis carolinensis
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