TAF1 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 250kDa 蛋白 (TAF1)

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. 再加上,我们可以发TAF1 抗体 (81)TAF1 试剂盒 (8)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
小鼠 TAF1 TAF1 270627  
大鼠 TAF1 TAF1 317256  
TAF1 6872 P21675
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Showing 4 out of 8 products:

产品编号 Origin 资源 标记 图像 规格 交付 价格 详细
大肠杆菌(E. Coli) GST tag 20 μg 2至3个工作日
小麦胚 GST tag 10 μg 11至12个工作日
大肠杆菌(E. Coli) His tag,DYKDDDDK Tag Recombinant TAF1 (1398-1524) activity using AlphaScreen. TAF1 (1398-1524) activity was assessed using an AlphaScreen® assay testing various buffer formulations. This data was generated and kindly provided courtesy of ChemPartner. Recombinant TAF1 (1398-1524) protein gel. TAF1 (1398-1524) protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. 100 μg 1至2个工作日
Baculovirus infected Insect Cells GST tag   20 μg 1至2个工作日

TAF1 蛋白 by Origin and Source

Origin 在表达 标记
Human , , ,

更多TAF1 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 250kDa (TAF1)互动伙伴

Fruit Fly (Drosophila melanogaster) TAF1 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 250kDa (TAF1) interaction partners

  1. TAF1 is involved in both establishing an upper limit of transcription during induction and efficiently turning the gene off once the inducer is removed

  2. results suggest stepwise assembly of a testis-specific TFIID complex (tTFIID) whereby a TAF1 isoform, presumably TAF1-2, is recruited to a core subassembly of tTAFs in spermatocyte nucleoli

  3. TAF1 pre-mRNA elements identified in this study are independently targeted by developmental signaling pathways to result in tissue-specific inclusion of exon 12a and/or 13a.

  4. The existence of a stable coactivator supercomplex consisting of the chromatin-remodeling factor Brahma (SWI/SNF) and the transcription initiation factor TFIID, is shown.

Mouse (Murine) TAF1 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 250kDa (TAF1) interaction partners

  1. these result suggests that the N-Taf1 gene has an important role in non-dividing neuronal cell rather than in cell division and proliferation during neurogenesis.

  2. Data show that Taf1 is decreased at the osteogenic initiation stage in the maxilla of Tgfbr2 mutant mice.

  3. Appears in pronuclei 6 h post-fertilization and reached a relatively high level before zygotic genome activation.

Human TAF1 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 250kDa (TAF1) interaction partners

  1. Our findings highlight the regulatory networks among TFs, lncRNAs, miRNAs, and mRNAs in hepatocellular carcinoma (HCC). Several key molecules, such as hsa-miR-195, lncRNA MALAT1 and TFs TAF1 and HNF4alpha, may contribute to the progression of HCC.

  2. These data directly link sequence variation within the XDP-specific SVA sequence to phenotypic variability in clinical disease manifestation and provide insight into potential mechanisms by which this intronic retroelement may induce transcriptional interference in TAF1 expression.

  3. present a case study where a combination of experimental techniques and computational simulations was used to comprehensively characterize the binding and structure-affinity relationships for a series of Bromosporine-based bivalent bromodomain ligands with a bivalent protein, Transcription Initiation Factor TFIID subunit 1 (TAF1).

  4. The results converge on TAF1 dysfunction in peripheral models of X-linked dystonia-parkinsonism, and provide evidence of altered expression of a canonical gene in this disease. Furthermore, this study illustrates a link between the previously described genetic alterations and TAF1 dysfunction at the transcriptome level.

  5. TAF1 and TAF1L genes harbored not only somatic mutations but also mutational ITH.

  6. N-TAF1 expression is impaired in X-linked dystonia-parkinsonism.

  7. The bromodomains of BRD9, CECR2, and the second bromodomain of TAF1 recognize the longer butyryl mark on histones. In addition, the TAF1 second bromodomain is capable of binding crotonyl marks.

  8. TAF1 variants are associated with dysmorphic features, intellectual disability, and neurological manifestations.

  9. are necessary and sufficient to overcome the barrier of species specificity for human rDNA transcription in mouse cells

  10. TAF1 winged helix domain has intrinsic DNA-binding activity, which depends on characteristic residues that are commonly used by winged helix fold proteins for interacting with DNA.

  11. the surface of the TAF1-TAF7 complex contains two prominent conserved surface pockets, one of which binds selectively to an inhibitory trimethylated histone H3

  12. This study demonistrated that frequencies of polymorphic genotype and allele of TAF1 gene were not different in patients than in control group and that they were not significant for cerebral venous thrombosis.

  13. As cellular ATP levels recover, TAF1 is able to phosphorylate p53 on Thr55, which leads to dissociation of p53 from the p21 promoter.

  14. Lower efficiency of microRNA synthesis directed by TATA box or NF-kappaappaB is a consequence of frequent transcription initiations that lead to RNA polymerase II crowding at pause sites and premature termination.

  15. Although d3-d4 also affect genes potentially related to neurodegenerative processes, their physiologic role as splice variants of TAF1 awaits further exploration

  16. analysis of phosphorylation-dependent regulation of cyclin D1 and cyclin A gene transcription by TFIID subunits TAF1 and TAF7

  17. In the Brazilian population, genetic variations in both uPA and TAFI were not relevant to endometriosis and/or infertility.

  18. TAF7, until now considered only a TFIID component and regulator of TAF1-dependent transcription, also regulates TAF1-independent transcription

  19. 285 patients with autosomal -dominant ataxia were examined, and abnormal or borderline expansions of CAG/CAA within TBP were found.

  20. Results indicate that increased TAF1 expression is associated with progression of human prostate cancers to the lethal castration-resistant state.



Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. This gene is part of a complex transcriptional unit (TAF1/DYT3), wherein some products share exons with TAF1 as well as additional exons downstream.

Gene names and symbols associated with TAF1

  • TBP-associated factor 1 (Taf1)
  • TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa (TAF1)
  • transcription initiation factor TFIID subunit 1 (LOC5567420)
  • transcription initiation factor TFIID subunit 1 (CpipJ_CPIJ003658)
  • transcription initiation factor TFIID subunit 1 (TAF11.1)
  • transcription initiation factor TFIID, subunit TAF1 (HAF1501)
  • transcription initiation factor TFIID, subunit TAF1 (HAF1502)
  • TATA-box binding protein associated factor 1 (TAF1)
  • transcription initiation factor TFIID subunit 1 (LOC100457071)
  • TATA-box binding protein associated factor 1 (Taf1)
  • 250kDa 蛋白
  • AU015687 蛋白
  • B430306D02Rik 蛋白
  • BA2R 蛋白
  • BG:DS00004.13 蛋白
  • Ccg-1 蛋白
  • CCG1 蛋白
  • CCGS 蛋白
  • cel 蛋白
  • cell 蛋白
  • CG17603 蛋白
  • d230 蛋白
  • Dmel\\CG17603 蛋白
  • dmTAF1 蛋白
  • dmTAF[[II]]230 蛋白
  • dTAF230 蛋白
  • dTAF250 蛋白
  • dTAFII250 蛋白
  • dTAF[[II]]230 蛋白
  • dTAF[[II]]250 蛋白
  • DYT3 蛋白
  • DYT3/TAF1 蛋白
  • EfW1 蛋白
  • KAT4 蛋白
  • l(3)84Ab 蛋白
  • N-TAF1 蛋白
  • NSCL2 蛋白
  • OF 蛋白
  • p230 蛋白
  • p250 蛋白
  • RGD1562050 蛋白
  • SR3-5 蛋白
  • TAF 蛋白
  • TAF(II)250 蛋白
  • TAF1 蛋白
  • Taf1p 蛋白
  • TAF2A 蛋白
  • Taf200 蛋白
  • Taf230 蛋白
  • Taf250 蛋白
  • TAF250/230 蛋白
  • TAFII-250 蛋白
  • TAFII250 蛋白
  • TAF[II]250 蛋白
  • TAF[[II]] 蛋白
  • TAF[[II]]230 蛋白
  • Taf[[II]]250 蛋白
  • TAF[[II]]250/230 蛋白
  • TFIID 蛋白
  • TFIID TAF250 蛋白
  • XDP 蛋白

Protein level used designations for TAF1

CG17603-PA , CG17603-PB , CG17603-PC , CG17603-PD , CG17603-PE , TATA-associated factor 250 , TBP-associated factor , TBP-associated factor 250 , TBP-associated factor 250kD , TFIID 230 kda subunit , Taf1-PA , Taf1-PB , Taf1-PC , Taf1-PD , Taf1-PE , cell lethal , suppressor of Ras85D 3-5 , TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa , transcription initiation factor TFIID subunit 1 , transcription initiation factor TFIID, subunit TAF1 , TBP-associated factor 1-like , transcription initiation factor TFIID subunit 1-like , TAF(II)250 , TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, neuron specific isoform , TAFII-250 , TBP-associated factor 250 kDa , cell cycle gene 1 protein , cell cycle, G1 phase defect , p250 , transcription initiation factor TFIID 250 kDa subunit , complementation of cell cycle block, G1-to-S , transcription factor TFIID p250 polypeptide , Cell cycle gene 1 protein , Transcription initiation factor TFIID 250 kDa subunit

40813 Drosophila melanogaster
736556 Pan troglodytes
5567420 Aedes aegypti
6035208 Culex quinquefasciatus
8250009 Micromonas sp. RCC299
5930833 Physcomitrella patens subsp. patens
5942503 Physcomitrella patens subsp. patens
100348935 Oryctolagus cuniculus
100457071 Pongo abelii
270627 Mus musculus
317256 Rattus norvegicus
6872 Homo sapiens
491950 Canis lupus familiaris
101838159 Mesocricetus auratus
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