蛋白简介

Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity. {ECO:0000250|UniProtKB:Q8TEV9}.

Gene names and symbols associated with SMCR8

• Smith-Magenis syndrome chromosome region, candidate 8 (SMCR8) 抗体
• Smith-Magenis syndrome chromosome region, candidate 8 homolog (human) (Smcr8) 抗体
• Smith-Magenis syndrome chromosome region, candidate 8 (Smcr8) 抗体
• Smith-Magenis syndrome chromosome region, candidate 8b (smcr8b) 抗体

• 2310076G09Rik 抗体
• AI642055 抗体
• D030073L15Rik 抗体
• RGD1564621 抗体
• smcr8 抗体

Protein level used designations for SMCR8

Smith-Magenis syndrome chromosomal region candidate gene 8 protein , Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog , Smith-Magenis syndrome chromosome region, candidate 8 homolog , Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog B , guanine nucleotide exchange protein smcr8b , smith-Magenis syndrome chromosomal region candidate gene 8-B protein homolog