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SMCR8 产品

(Smith-Magenis Syndrome Chromosome Region, Candidate 8 (SMCR8))

Categories

Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity. {ECO:0000250|UniProtKB:Q8TEV9}.

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Featured SMCR8 Categories

SMCR8 抗体

High quality antibodies with extensive validation data.

Recommended SMCR8 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IF, IHC (p)
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Cat. No. ABIN5588427
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application ELISA
Validations
Cat. No. ABIN7095499
Quantity 100 μL
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Reactivity Human
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Cat. No. ABIN7452051
Quantity 100 μg
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Recommended SMCR8 蛋白

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Reactivity
Source
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Cat. No.
Quantity
Datasheet
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Source Insect Cells
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Datasheet Datasheet
Reactivity Human
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Cat. No. ABIN3076918
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Synonyms and alternative names related to SMCR8

Smith-Magenis syndrome chromosome region, candidate 8 (SMCR8), Smith-Magenis syndrome chromosome region, candidate 8 homolog (human) (Smcr8), Smith-Magenis syndrome chromosome region, candidate 8 (Smcr8), Smith-Magenis syndrome chromosome region, candidate 8b (smcr8b), 2310076G09Rik, AI642055, D030073L15Rik, RGD1564621, smcr8

Protein level used designations for SMCR8

  • Smith-Magenis syndrome chromosomal region candidate gene 8 protein
  • Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog
  • Smith-Magenis syndrome chromosome region, candidate 8 homolog
  • Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog B
  • guanine nucleotide exchange protein smcr8b
  • smith-Magenis syndrome chromosomal region candidate gene 8-B protein homolog
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