anti-Rotatin (RTTN) 抗体

RTTN encodes a large protein whose specific function is unknown.

列出全部抗体 基因 基因ID UniProt
 RTTN RTTN 25914 Q86VV8
小鼠 RTTN RTTN 246102 Q8R4Y8
大鼠 RTTN RTTN 291377  
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产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 IHC, IHC (p) Immunohistochemistry: rotatin Antibody [NBP1-90554] - Staining of human stomach, lower shows strong cytoplasmic positivity in gastric parietal cells. 0.1 mL Log in to see 10至13个工作日
非结合性 ICC, IF, IHC, IHC (p) Immunohistochemistry-Paraffin: rotatin Antibody [NBP1-90555] - Staining of human stomach, lower shows moderate cytoplasmic positivity in glandular cells. Immunocytochemistry/Immunofluorescence: rotatin Antibody [NBP1-90555] - Staining of human cell line A-431 shows positivity in mitochondria. 0.1 mL Log in to see 10至13个工作日
非结合性 IHC (p)   100 μL Log in to see 11至12个工作日


Human Rotatin (RTTN) interaction partners

  1. RTTN directly interacts with STIL (显示 STIL 抗体) and acts downstream of STIL (显示 STIL 抗体)-mediated centriole assembly, contributing to building full-length centrioles.

  2. We found a novel homozygous mutation in RTTN associated with microcephalic PD as well as complex brain malformations and congenital dermatitis, thus expanding the phenotypic spectrum of both RTTN-associated diseases and ciliary dysfunction.

  3. RTTN mutations cause primary microcephaly and primordial dwarfism in humans.

  4. RTTN mutations therefore link aberrant ciliary function to abnormal development and organization of the cortex in human individuals.

  5. Study characterizing mouse rotatin gene.

Mouse (Murine) Rotatin (RTTN) interaction partners

  1. cloning and characterization of rotatin

  2. No turning (nt), a recessive lethal mutation causing left-right and axial patterning defects is likely elicited by deficiency of Rttn on chromosome 18.

Rotatin (RTTN) 抗原简介


This gene encodes a large protein whose specific function is unknown. Absence of the orthologous protein in mouse results in embryonic lethality with deficient axial rotation, abnormal differentiation of the neural tube, and randomized looping of the heart tube during development. In human, mutations in this gene are associated with polymicrogyria with seizures. In human fibroblasts this protein localizes at the ciliary basal bodies. Given the intracellular localization of this protein and the phenotypic effects of mutations, this gene is suspected of playing a role in the maintenance of normal ciliary structure which in turn effects the developmental process of left-right organ specification, axial rotation, and perhaps notochord development.

Gene names and symbols associated with anti-Rotatin (RTTN) 抗体

  • rotatin (RTTN) 抗体
  • rotatin (Rttn) 抗体
  • rotatin (LOC100074695) 抗体
  • rotatin (rttn) 抗体
  • rotatin (LOC100542421) 抗体
  • 4921538A15Rik 抗体
  • AI666264 抗体
  • C530033I08Rik 抗体
  • D230040K24 抗体

Protein level used designations for anti-Rotatin (RTTN) 抗体


25914 Homo sapiens
246102 Mus musculus
291377 Rattus norvegicus
421023 Gallus gallus
455466 Pan troglodytes
483940 Canis lupus familiaris
615378 Bos taurus
703989 Macaca mulatta
100020422 Monodelphis domestica
100052029 Equus caballus
100074695 Ornithorhynchus anatinus
100151439 Danio rerio
100302015 Oryzias latipes
100343652 Oryctolagus cuniculus
100379860 Xenopus (Silurana) tropicalis
100452537 Pongo abelii
100474442 Ailuropoda melanoleuca
100542421 Meleagris gallopavo
100623296 Sus scrofa