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Rotatin 抗体

(Rotatin (RTTN))
This gene encodes a large protein whose specific function is unknown. Absence of the orthologous protein in mouse results in embryonic lethality with deficient axial rotation, abnormal differentiation of the neural tube, and randomized looping of the heart tube during development. In human, mutations in this gene are associated with polymicrogyria with seizures. In human fibroblasts this protein localizes at the ciliary basal bodies. Given the intracellular localization of this protein and the phenotypic effects of mutations, this gene is suspected of playing a role in the maintenance of normal ciliary structure which in turn effects the developmental process of left-right organ specification, axial rotation, and perhaps notochord development. [provided by RefSeq, Jan 2013].

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Featured Rotatin Categories

Rotatin 抗体

High quality antibodies with extensive validation data.

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Synonyms and alternative names related to Rotatin

rotatin (RTTN), rotatin (Rttn), rotatin (LOC100074695), rotatin (rttn), rotatin (LOC100542421), 4921538A15Rik, AI666264, C530033I08Rik, D230040K24

Protein level used designations for Rotatin

  • rotatin
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