This gene belongs to the protocadherin subfamily within the cadherin superfamily. The encoded protein is a membrane protein found at cell-cell boundaries. It is involved in neural cell adhesion, suggesting a possible role in neuronal development. The protein includes an extracelllular region, containing 7 cadherin-like domains, a transmembrane region and a C-terminal cytoplasmic region. Cells expressing the protein showed cell aggregation activity. Alternative splicing occurs in this gene. [provided by RefSeq, Jul 2008].
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Koppelman, Meyers, Howard, Zheng, Hawkins, Ampleford, Xu, Koning, Bruinenberg, Nolte, van Diemen, Boezen, Timens, Whittaker, Stine, Barton, Holloway, Holgate, Graves, Martinez, van Oosterhout et al.: "Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness. ..." in: American journal of respiratory and critical care medicine, Vol. 180, Issue 10, pp. 929-35, (2009) (PubMed).