(Protein Kinase C, delta Binding Protein (PRKCDBP))
The protein encoded by this gene was identified as a binding protein of the protein kinase C, delta (PRKCD). The expression of this gene in cultured cell lines is strongly induced by serum starvation. The expression of this protein was found to be down-regulated in various cancer cell lines, suggesting the possible tumor suppressor function of this protein. [provided by RefSeq, Jul 2008].
Bai, Deng, Li, Wang, An, Deli, Gao, Xie, Dai, Cong: "Down-regulation of the cavin family proteins in breast cancer." in: Journal of cellular biochemistry, Vol. 113, Issue 1, pp. 322-8, (2011) (PubMed).
McMahon, Zajicek, Li, Peyton, Minna, Hernandez, Luby-Phelps, Anderson: "SRBC/cavin-3 is a caveolin adapter protein that regulates caveolae function." in: The EMBO journal, Vol. 28, Issue 8, pp. 1001-15, (2009) (PubMed).
Bastiani, Liu, Hill, Jedrychowski, Nixon, Lo, Abankwa, Luetterforst, Fernandez-Rojo, Breen, Gygi, Vinten, Walser, North, Hancock, Pilch, Parton: "MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes." in: The Journal of cell biology, Vol. 185, Issue 7, pp. 1259-73, (2009) (PubMed).
Izumi, Hirai, Tamai, Fujise-Matsuoka, Nishimura, Ohno: "A protein kinase Cdelta-binding protein SRBC whose expression is induced by serum starvation." in: The Journal of biological chemistry, Vol. 272, Issue 11, pp. 7381-9, (1997) (PubMed).