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The protein encoded by NPM3 is related to the nuclear chaperone phosphoproteins, nucleoplasmin and nucleophosmin.
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Human Polyclonal NPM3 Primary Antibody for IHC, IHC (p) - ABIN4341067
Hernández-Ortega, Garcia-Esparcia, Gil, Lucas, Ferrer: Altered Machinery of Protein Synthesis in Alzheimer's: From the Nucleolus to the Ribosome. in Brain pathology (Zurich, Switzerland) 2016
Studies indicate that histone chalerones nucleoplasmin (显示 NPM1 抗体) (NPM2 (显示 NPM2 抗体)/NPM3) preferentially associated with histones H2A-H2B in the egg and the nuclear autoantigenic sperm protein (NASP (显示 NASP 抗体)) families.
Characterization of the sperm chromatin decondensation and nucleosome assembly activities of homo- and hetero-oligomers of NPM1 (显示 NPM1 抗体),NPM2 (显示 NPM2 抗体) and NPM3.
NPM3 lacks intrinsic histone chaperone activity, inhibits histone assembly activity of NPM1 (显示 NPM1 抗体) in vitro, and dramatically enhances transcription in a cellular system.
Acetylation of transition protein 2 (TP2) by KAT3B (p300 (显示 EP300 抗体)) alters its DNA condensation property and interaction with putative histone chaperone NPM3.
Overexpression of a mutant of NPM3 that did not interact with B23 (显示 NPM1 抗体) did not alter pre-rRNA synthesis and processing, suggesting that the interaction of NPM3 with B23 (显示 NPM1 抗体) plays a role in the ribosome biogenesis
The protein encoded by this gene is related to the nuclear chaperone phosphoproteins, nucleoplasmin and nucleophosmin. This protein is strongly expressed in diverse cell types where it localizes primarily to the nucleus. Based on its similarity to nucleoplasmin and nucleophosmin, this protein likely functions as a molecular chaperone in the cell nucleus.
nucleophosmin/nucleoplasmin family, member 3
, nucleoplasmin 3
, nucleophosmin/nucleoplasmin, 3
, nucleophosmin/nucleoplasmin 3 S homeolog