anti-Neutrophil Cytosolic Factor 4, 40kDa (NCF4) 抗体

The protein encoded by NCF4 is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. 再加上,我们可以发Neutrophil Cytosolic Factor 4, 40kDa 蛋白 (11)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
NCF4 17972 P97369
NCF4 500904  
NCF4 4689 Q15080
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antibodies-online.cn销售最多的anti-Neutrophil Cytosolic Factor 4, 40kDa 抗体

Showing 10 out of 140 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-NCF4 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  HepG2 cell lysate 100 μL 2至3个工作日
$289.00
详细
Cow 非结合性 WB WB Suggested Anti-NCF4 Antibody Titration:  0.2-1 ug/ml  Positive Control:  Human Thymus 100 μL 2至3个工作日
$319.00
详细
非结合性 WB WB Suggested Anti-NCF4 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Human Muscle WB Suggested Anti-NCF4  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control: Human Muscle 100 μL 2至3个工作日
$289.00
详细
山羊 非结合性 IHC, ELISA, WB ABIN190755 (0.5µg/ml) staining of Daudi cell lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg 6至7个工作日
$429.84
详细
非结合性 IHC, WB Immunohistochemical analysis of p40 phox staining in human tonsil formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of p40 phox expression in MCF7 (A) whole cell lysates. 200 μL 13至14个工作日
$487.50
详细
非结合性 IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human ovary, using p40 phox (Phospho-Thr154) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg 2至3个工作日
$302.50
详细
非结合性 IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human ovary tissue, using p40 phox (Ab-154) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg 2至3个工作日
$302.50
详细
非结合性 FACS, IHC (p), WB Western blot analysis of NCF4 antibody (C-term) (ABIN391905) in K562 cell line lysates (35 µg/lane). NCF4 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human lymphoma reacted with NCF4 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL 10至11个工作日
$385.00
详细
山羊 非结合性 ELISA, IHC, IHC (p), WB Human Spleen (formalin-fixed, paraffin-embedded) stained with NCF4 antibody ABIN462290 followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. Human Tonsil (formalin-fixed, paraffin-embedded) stained with NCF4 antibody ABIN462290 followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. 50 μg 11至14个工作日
$484.00
详细
非结合性 IF/ICC, IHC, WB Western blot analysis of extracts of various cell lines, using NCF4 antibody (ABIN5971122) at 1/1000 dilution. Immunohistochemistry of paraffin-embedded rat brain using NCF4 Antibody (ABIN5971122) at dilution of 1/100 (40x lens). 100 μL 11至16个工作日
$426.40
详细

引用最多的anti-Neutrophil Cytosolic Factor 4, 40kDa 抗体

  1. Dog (Canine) Polyclonal NCF4 Primary Antibody for ELISA, WB - ABIN547956 : Rioux, Xavier, Taylor, Silverberg, Goyette, Huett, Green, Kuballa, Barmada, Datta, Shugart, Griffiths, Targan, Ippoliti, Bernard, Mei, Nicolae, Regueiro, Schumm, Steinhart, Rotter, Duerr, Cho, Daly et al.: Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. ... in Nature genetics 2007 (PubMed)

  2. Human Polyclonal NCF4 Primary Antibody for IHC, WB - ABIN6712099 : Wang, Yang, Han, Li, Jiang, Tian, Du, Li: NADPH oxidases mediate a cellular "memory" of angiotensin II stress in hypertensive cardiac hypertrophy. in Free radical biology & medicine 2015 (PubMed)

更多抗Neutrophil Cytosolic Factor 4, 40kDa的相互作用对抗体

Mouse (Murine) Neutrophil Cytosolic Factor 4, 40kDa (NCF4) interaction partners

  1. These studies demonstrate a critical role of phosphatidylinositol 3-phosphate-p40(phox) binding for optimal activation of the NADPH oxidase in macrophages.

  2. Our data reveal a specific role for NCF4-mediated intracellular ROS production in regulating autoimmunity and chronic inflammation.

  3. p40phox deficiency leads to upregulation of chemokine receptor 1 and downregulation of fucosyltransferases and sialyltransferases involved in glycan modifications during experimental intestinal inflammation.

  4. cooperation of p40(phox) with p47(phox) for Nox2-based NADPH oxidase activation during Fcgamma receptor (FcgammaR)-mediated phagocytosis

  5. The defect in Reactive Oxygen Species production and killing of s aureus by p40(phox-/-) neutrophils defines p40(phox) as an essential component in bacterial killing.

  6. p40(phoxR58A/R58A) embryos do not develop normally but p40(phoxR58A/-) mice are viable and neutrophils from these animals exhibit significantly reduced oxidase responses compared to those from their p40(phox+/-) siblings.

  7. binding of the ternary complex to phagosomes can be temporally regulated by switching between adaptor proteins that have PX domains with distinct lipid-binding specificities

  8. Class III PI3K Vps34 is responsible for the synthesis of PtdIns(3)P on phagosomes containing either S aureus or E coli. PtdIns(3)P binding to p40(phox) is important for CD18-dependent activation oxidase activation in response to S aureus and E coli

  9. p40(phox) is prephosphorylated in resting endothelial cells and can compensate p47(phox) in keeping basal ROS production.

Human Neutrophil Cytosolic Factor 4, 40kDa (NCF4) interaction partners

  1. Tyrosine kinase substrate (Tks) proteins, analogous to the related proteins p47(phox), p40(phox) and NoxO1, also facilitate local generation of reactive oxygen species (ROS), which aid in signaling at invadopodia and/or podosomes to promote their activity. As their name suggests, Tks adaptor proteins are substrates for tyrosine kinases, especially Src. [review]

  2. Phosphoinositol 3-phosphate regulates reactive oxygen species production by maintaining p40phox and p67phox at the phagosomal membrane.

  3. NCF4 polymorphism was associated with Crohn's disease, but not ulcerative colitis in Caucasian--{REVIEW}

  4. NCF4 may induce ex- pression of NADPH oxidase enzymes, such as p67phox, p47phox, p22phox and NOX2, which lead to increased ROS levels.

  5. Germline variation in NCF4, an innate immunity gene, is associated with an increased risk of colorectal cancer.

  6. The contribution of the functionally relevant NADPH polymorphisms rs1883112 and rs4673 to anthracycline-related heart lesions provides a plausible explanation for their modulation of cardiotoxicity.

  7. Constitutive and inducible intracellular production of reactive oxygen species (ROS) is higher in B cells expressing functional p40phox, supporting a direct role for p40phox in regulating B cell intracellular ROS generation.

  8. Genome-wide association studies-reported associations between the NELL1, NCF4, and FAM92B genes and susceptibility to Crohn's disease could not be replicated in Canadian children and young adults.

  9. Younger age at diagnosis, complicated disease behavior, and ileal disease location are risk factors for perianal CD. First report of an association of the NCF4 gene with perianal disease.

  10. cooperation of p40(phox) with p47(phox) for Nox2-based NADPH oxidase activation during Fcgamma receptor (FcgammaR)-mediated phagocytosis

  11. Results demonstrate that PBEF can prime for PMN respiratory burst activity by promoting p40 and p47 translocation to the membrane.

  12. no association between SNP rs4821544 and the presence of granulomas in Crohn's disease

  13. cytosolic localisation depends on direct interaction with F-actin

  14. All mutations and some polymorphisms identified in the NCF4 gene in the autosomal forms of chronic granulomatous disease are listed. Review.

  15. p40(phox) functions primarily to regulate Fc gamma receptor-induced NADPH oxidase activity rather than assembly, and stimulates superoxide production via a phosphatidylinositol-3-phosphate signal that increases after phagosome internalization.

  16. detailed study of the protein-protein interactions that occur in the p40-p47-p67(phox) complex of the resting oxidase

  17. p22(phox), gp91(phox), p47(phox), p67(phox), and p40(phox) existed as a functional complex in the cytoskeletal fraction.

  18. Involvement of protein kinase D in Fc gamma-receptor activation of the NADPH oxidase in neutrophils

  19. Multiple PU.1 sites cooperate in the regulation of p40(phox) transcription during granulocytic differentiation of myeloid cells.

  20. p40phox and p47phox PX domains interact with PI-containing membranes

Cow (Bovine) Neutrophil Cytosolic Factor 4, 40kDa (NCF4) interaction partners

  1. NCF4 expression was regulated by the miRNA-mRNA interaction mechanism, and an important role for NCF4 in mastitis susceptibility in dairy cow was suggested.

  2. Study proposes that NCF4 splice variants generated by functional SNP are important risk factors for mastitis susceptibility in dairy cows.

Neutrophil Cytosolic Factor 4, 40kDa (NCF4) 抗原简介

蛋白简介

The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Gene names and symbols associated with NCF4

  • neutrophil cytosolic factor 4 (ncf4) 抗体
  • neutrophil cytosolic factor 4 (Ncf4) 抗体
  • neutrophil cytosolic factor 4 (NCF4) 抗体
  • AI451400 抗体
  • NCF 抗体
  • P40PHOX 抗体
  • SH3PXD4 抗体

Protein level used designations for NCF4

p40phox protein , neutrophil cytosolic factor 4 , NADPH oxidase cytosolic protein p40phox , NCF-4 , neutrophil NADPH oxidase factor 4 , neutrophil cytosol factor 4 , p40-phox , SH3 and PX domain-containing protein 4

GENE ID SPECIES
445891 Takifugu rubripes
100136241 Oncorhynchus mykiss
17972 Mus musculus
500904 Rattus norvegicus
4689 Homo sapiens
481277 Canis lupus familiaris
507859 Bos taurus
100009359 Oryctolagus cuniculus
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