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The protein encoded by MAP3K10 is a member of the serine/threonine kinase family.
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Human Polyclonal MAP3K10 Primary Antibody for IHC (p), WB - ABIN392424
Humphrey, Newcomb, Yu, Hao, Yu, Krajewski, Du, Jhala: Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells. in The Journal of biological chemistry 2010
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MST interaction with MOB1 (显示 MOBKL3 抗体) is not essential for development and tissue growth control.
We identified a direct target of miR (显示 MLXIP 抗体)-155 as MAP3K10 in osteosarcoma
MAP3K4 (显示 MAP3K4 抗体) is sufficiently mediate the TGFbeta (显示 TGFB1 抗体)-induced phosphorylation of p38 MAPK (显示 MAPK14 抗体) in MEFs and HaCaT cells.
A novel and important role for MAP3K10 in the proliferation and chemoresistance of pancreatic ductal adenocarcinoma.
This study showed that show that RUNX3 (显示 RUNX3 抗体) is a principal and evolutionarily conserved component of the MST pathway.
Mechanism of MAP kinase (显示 MAPK1 抗体) activation by TNF (显示 TNF 抗体) requires Src (显示 SRC 抗体)-dependent activation of Vav (显示 VAV1 抗体), activation of Rac (显示 AKT1 抗体)/Cdc42 (显示 CDC42 抗体), and the engagement of the Rac (显示 AKT1 抗体)/Cdc42 (显示 CDC42 抗体) interaction site on MLK2 and 3.
Data show that miR (显示 MLXIP 抗体)-181b contributed to proliferation of AML (显示 RUNX1 抗体) cells by targeting MLK2.
MLK2 has a role in vesicle formation and endosome recycling by binding to clathrin
demonstrate Alien-MLK2 interaction and also show that MLK2 is able to phosphorylate Alien; Alien, DAX-1 (显示 NR0B1 抗体) and thyroid hormone receptor (显示 THRA 抗体) mediated transcriptional silencing is strongly enhanced in the presence of active MLK2
MLK2 and -3 are required for activation of JNK (显示 MAPK8 抗体) and p38 (显示 CRK 抗体) by ectopically expressed GCK (显示 GCK 抗体)
There is extensive functional redundancy between MLK1 (显示 MAP3K9 抗体) and MLK2, and the other member of the family, MLK3 (显示 KCNK7 抗体), none of which are required for survival in mouse.
Mixed lineage kinase (显示 MAP3K12 抗体) phosphorylates transcription factor E47 (显示 TCF3 抗体) and inhibits TrkB (显示 NTRK2 抗体) expression to link neuronal death and survival pathways
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.
mitogen-activated protein kinase kinase kinase 10
, mixed-lineage kinase 2
, MKN28 derived nonreceptor_type serine/threonine kinase
, MKN28 kinase
, mixed lineage kinase 2
, protein kinase MST
, MKN28 derived nonreceptor_type
, serine/threonine kinase