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Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus.
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Human Polyclonal MCRS1 Primary Antibody for IF, IHC (p) - ABIN523843
Xu, Zheng, Zhang, Zhao, Zhang, Wu, Wu, Wang, Wang, Zhang: MSP58 knockdown inhibits the proliferation of esophageal squamous cell carcinoma in vitro and in vivo. in Asian Pacific journal of cancer prevention : APJCP 2012
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Results suggest that dMCRS2 is required for loading of RNAP II complexes on the cyclin (显示 PCNA 抗体) gene promoters.
Study shows that MCRS1 binds to cytoplasmic dynein (显示 DYNC1H1 抗体) and contributes to the establishment of centriolar satellites and ciliogenesis.
MSP58 downregulation suppressed the proliferation and invasion of renal cell carcinoma (显示 MOK 抗体) cells.
MCRS1 is phosphorylated by the Aurora-A kinase (显示 AURKA 抗体) in mitosis on Ser35/36.
RINT-1 (显示 RINT1 抗体) interacts with MSP58 and UBF (显示 UBTF 抗体) within nucleoli and plays a role in ribosomal gene transcription.
The immunoreactivity score (IRS (显示 IARS 抗体)) of MSP58 increased with tumor grade with grade IV gliomas exhibiting the highest expression and showed a highly significant positive correlation with the Ki-67 (显示 MKI67 抗体) index (r = 0.65, P < 0.001).
Suggest that MSP58 plays an important role in tumorigenesis and progression and may help predict the prognosis of gastric cancer patients.
MCRS1 overexpression induced non-small cell lung cancer proliferation through the miR (显示 MLXIP 抗体)-155-Rb1 (显示 RB1 抗体) pathway and DNA copy-number amplification is one of the mechanisms underlying MCRS1 overexpression in non-small cell lung cancer.
MSP58 subnuclear localization is regulated by two nuclear import signals, and proper subcellular localization of MSP58 is critical for its role in transcriptional regulation. A molecular mechanism controls nuclear and nucleolar localization of MSP58.
BAP1 (显示 RNF2 抗体) loss and MCRS1 down-regulation in renal cell carcinoma (显示 MOK 抗体) are associated with adverse clinicopathological features.
MiR (显示 MLXIP 抗体)-129* down-regulation induced MCRS1 overexpression.
Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity.
, lethal (3) rG166
, reduction in Cnn dots 5
, microspherule protein 1
, microspherule protein 1-like
, 58 kDa microspherule protein
, nucleolar protein
, INO80 complex subunit J
, INO80 complex subunit Q
, cell cycle-regulated factor (78 kDa)
, cell cycle-regulated factor p78