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Acts as a transcriptional coactivator for NOTCH proteins. 再加上，我们可以发和数多这个蛋白质的别的产品。
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Human Polyclonal MAML2 Primary Antibody for IHC, IP - ABIN151565
Oyama, Harigaya, Sasaki, Okamura, Kokubo, Saga, Hozumi, Suganami, Tamura, Nagase, Koga, Nishimura, Sakamoto, Sato, Yoshida, Kitagawa: Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo. in Development (Cambridge, England) 2011
CRTC3 (显示 CRTC3 抗体)-MAML2 gene fusion occurs in hidradenomas.
findings suggest further characterization of MECs is needed before considering the CRTC1 (显示 CRTC1 抗体)/3-MAML2 gene fusion as a prognostic biomarker
It is, to our knowledge, the first case of B acute lymphoblastic leukemia with this fusion gene. At the molecular level, two rearrangements were detected using RNA sequencing juxtaposing exon 7 to exon 2 and exon 9 to intron 1-2 of the KMT2A (显示 MLL 抗体) and MAML2 genes respectively, and one rearrangement using Sanger sequencing juxtaposing exon 8 and exon 2.
we demonstrated that MDM2 (显示 MDM2 抗体) is frequently overexpressed in clear cell carcinomas, and that MDM2 (显示 MDM2 抗体) overexpression is associated with poor prognosis.
Warthin-like mucoepidermoid carcinoma (MEC (显示 CCL28 抗体)), and now a ciliated form of MEC (显示 CCL28 抗体), are newly described variants of a common salivary gland carcinoma. MAML2 rearrangements were identified in all cases. These unusual variants appear to consistently harbor MAML2 fusions-a finding that establishes a clear link to conventional MEC (显示 CCL28 抗体).
MECT1 (显示 CRTC1 抗体)-MAML2 fusion transcript is a driver genetic event in the pathogenesis of primary bronchopulmonary mucoepidermoid carcinoma
A subgroup of MAML2 fusion-negative mucoepidermoid carcinomas are actually clear cell carcinoma of the salivary gland with EWSR1 (显示 EWSR1 抗体) translocation.
This condensed chromatin structure is associated with binding of DNMT3B (显示 DNMT3B 抗体) and decreased occupancy of OCT1 (显示 POU2F1 抗体) transcription factor at MAML2 enhancer, suggesting a role of DNMT3B (显示 DNMT3B 抗体) in increasing methylation of MAML2 after stilbenoid treatment.
revealing neither correlation between the cellular composition and CRTC1 (显示 CRTC1 抗体)-MAML2 fusions nor presence of CRTC3 (显示 CRTC3 抗体)-MAML2 fusions in cutaneous hidradenoma
MAML2 rearrangement is common and specific for MEC (显示 CCL28 抗体), which makes it a useful diagnostic tool. MAML2 rearrangement also predicts a favorable prognosis.
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3 (By similarity).
mastermind like 2
, mastermind-like 2
, mastermind-like protein 2