anti-Mastermind-Like 2 (Drosophila) (MAML2) 抗体

Acts as a transcriptional coactivator for NOTCH proteins. 再加上,我们可以发和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
MAML2 270118  
MAML2 689844  
MAML2 84441 Q8IZL2
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Showing 10 out of 80 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB Host:  Rabbit  Target Name:  Maml2  Sample Type:  Mouse Stomach lysates  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2至3个工作日
豚鼠 非结合性 WB WB Suggested Anti-5930431H10 Antibody Titration:  0.2-1 ug/ml  Positive Control:  Mouse Kidney 100 μL Log in to see 2至3个工作日
小鼠 非结合性 FACS, IF, IHC (p) IHC testing of FFPE human bladder carcinoma with MAML2 antibody (clone MMLP2-1). IHC testing of FFPE human colon carcinoma with MAML2 antibody (clone MMLP2-1). 100 μg Log in to see 2至3个工作日
非结合性 IHC, IP, WB Western Blot and Immunoprecipitation: MAML2 Antibody [ABIN151565] - Detection of Human and Mouse MAML2 by Western Blot (h and m) and Immunoprecipitation (m). Samples: Whole cell lysate from HeLa (5, 15 and 50 mcg for WB, 1 mg for IP, 20% of IP loaded), 293T (T, 50 mcg) and mouse NIH3T3 (M, 50 mcg) cells. Antibodies: Affinity purified rabbit anti-MAML2 antibody (Cat. No. ABIN151565) used for WB at 0.04 mcg/ml (A) and 1 mcg/ml (B), and used for IP at 3 mcg/mg lysate. MAML2 was also immunoprecipitated by another rabbit anti-MAML2 antibodies and (Cat. No. ABIN151564).  Detection: Chemiluminescence with exposure times of 3 minutes (A) and 30 seconds (B). 0.1 mL Log in to see 7至9个工作日
非结合性 ELISA, WB   100 μL Log in to see 11至13个工作日
小鼠 CF®405S FACS, IF, IHC, ISt, WB   100 μL Log in to see 3至4个工作日
小鼠 CF405M FACS, IF, IHC, ISt, WB   100 μL Log in to see 3至4个工作日
小鼠 CF®640R FACS, IF, IHC, ISt, WB   100 μL Log in to see 3至4个工作日
小鼠 CF®647 FACS, IF, IHC, ISt, WB   100 μL Log in to see 3至4个工作日
小鼠 CF®543 FACS, IF, IHC, ISt, WB   100 μL Log in to see 3至4个工作日

引用最多的anti-MAML2 抗体

  1. Human Polyclonal MAML2 Primary Antibody for IHC, IP - ABIN151565 : Oyama, Harigaya, Sasaki, Okamura, Kokubo, Saga, Hozumi, Suganami, Tamura, Nagase, Koga, Nishimura, Sakamoto, Sato, Yoshida, Kitagawa: Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo. in Development (Cambridge, England) 2011 (PubMed)


Human Mastermind-Like 2 (Drosophila) (MAML2) interaction partners

  1. Two cases of breast mucoepidermoid carcinomas harboring CRTC1-MAML2 fusions are reported

  2. The expression of the MAML2 gene in penile cancers from men receiving first-line cisplatin-based chemotherapy predicted overall survival independent of clinical factors.

  3. LINC00473 acts as a promising biomarker and therapeutic target for human CRTC1-MAML2-positive Mucoepidermoid carcinomas.

  4. CRTC3-MAML2 gene fusion occurs in hidradenomas.

  5. findings suggest further characterization of MECs is needed before considering the CRTC1/3-MAML2 gene fusion as a prognostic biomarker

  6. It is, to our knowledge, the first case of B acute lymphoblastic leukemia with this fusion gene. At the molecular level, two rearrangements were detected using RNA sequencing juxtaposing exon 7 to exon 2 and exon 9 to intron 1-2 of the KMT2A and MAML2 genes respectively, and one rearrangement using Sanger sequencing juxtaposing exon 8 and exon 2.

  7. we demonstrated that MDM2 is frequently overexpressed in clear cell carcinomas, and that MDM2 overexpression is associated with poor prognosis.

  8. Warthin-like mucoepidermoid carcinoma (MEC), and now a ciliated form of MEC, are newly described variants of a common salivary gland carcinoma. MAML2 rearrangements were identified in all cases. These unusual variants appear to consistently harbor MAML2 fusions-a finding that establishes a clear link to conventional MEC.

  9. MECT1-MAML2 fusion transcript is a driver genetic event in the pathogenesis of primary bronchopulmonary mucoepidermoid carcinoma

  10. A subgroup of MAML2 fusion-negative mucoepidermoid carcinomas are actually clear cell carcinoma of the salivary gland with EWSR1 translocation.

  11. This condensed chromatin structure is associated with binding of DNMT3B and decreased occupancy of OCT1 transcription factor at MAML2 enhancer, suggesting a role of DNMT3B in increasing methylation of MAML2 after stilbenoid treatment.

  12. revealing neither correlation between the cellular composition and CRTC1-MAML2 fusions nor presence of CRTC3-MAML2 fusions in cutaneous hidradenoma

  13. MAML2 rearrangement is common and specific for MEC, which makes it a useful diagnostic tool. MAML2 rearrangement also predicts a favorable prognosis.

  14. Detection of the CRTC1/MAML2 fusion transcript provides useful information for MEC diagnosis but is not associated with differences in survival outcomes.

  15. The molecular basis underlying CRTC1-MAML2 oncogenic functions were identified in mucoepidermoid carcinoma cells.

  16. SNPs in Notch pathway genes may be predictors of cutaneous melanoma disease-specific survival.

  17. We identified MAML2 rearrangements in five of nine odontogenic cysts lined by mucus-secreting cells

  18. Translocation t(11;19)(q14-21;p12-13) in patients with Salivary mucoepidermoid carcinoma was reported , which results in fusion between exons 1 and 2 of MAML2 on chromosome 11q21.Fusion positive, MAML2 re-arrangements are present in 50-70 % of MECs.

  19. The high sensitivity and specificity of MAML2 rearrangement for central mucoepidermoid carcinoma points to its utility as a diagnostic adjunct in separating mucinous cystic lesions of the gnathic bones.

  20. MAML2 rearrangement appears frequent in PMEC and specific with this tumor. Both the presence of MAML2 rearrangement and absence of FLT1 tend to confer a favorable clinical outcome.

MAML2 抗原简介


Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3 (By similarity).

Gene names and symbols associated with MAML2

  • mastermind like 2 (Drosophila) (Maml2) 抗体
  • mastermind-like transcriptional coactivator 2 (Maml2) 抗体
  • mastermind like transcriptional coactivator 2 (MAML2) 抗体
  • 5930431H10 抗体
  • BC032967 抗体
  • MAM-3 抗体
  • MAM2 抗体
  • MAM3 抗体
  • MLL-MAML2 抗体

Protein level used designations for MAML2

mastermind like 2 , mastermind-like 2 , mastermind-like protein 2 , mam-2

270118 Mus musculus
689844 Rattus norvegicus
84441 Homo sapiens
521194 Bos taurus
485116 Canis lupus familiaris
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