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MAML2 抗体 (C-Term)

MAML2 适用: 人, 小鼠 WB, IP, IHC (fp) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7454661
发货至: 中国
  • 抗原 See all MAML2 抗体
    MAML2 (Mastermind-Like 2 (MAML2))
    抗原表位
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    适用
    • 26
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    人, 小鼠
    宿主
    • 16
    • 11
    克隆类型
    • 16
    • 11
    多克隆
    标记
    • 17
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MAML2 antibody is un-conjugated
    应用范围
    • 22
    • 12
    • 11
    • 9
    • 9
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))
    原理
    Rabbit anti-MAML2 Antibody, Affinity Purified
    预测反应
    Bovine
    纯化方法
    Affinity Purified
    免疫原
    between AA 1100 and C-term
    亚型
    IgG
    Top Product
    Discover our top product MAML2 Primary Antibody
  • 应用备注

    IHC: 1:200 - 1:1,000. Epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.

    IP: 1 - 4 μg/mg lysate

    WB: 1:2,000 - 1:15,000

    限制
    仅限研究用
  • 浓度
    200 μg/mL
    缓冲液
    Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    有效期
    12 months
  • 抗原
    MAML2 (Mastermind-Like 2 (MAML2))
    别名
    MAML2 (MAML2 产品)
    别名
    5930431H10 antibody, BC032967 antibody, MAM-3 antibody, MAM2 antibody, MAM3 antibody, MLL-MAML2 antibody, mastermind like 2 (Drosophila) antibody, mastermind-like transcriptional coactivator 2 antibody, mastermind like transcriptional coactivator 2 antibody, Maml2 antibody, MAML2 antibody
    背景
    Background: There are 3 MAML (mastermind-like) proteins in mammals (MAML1-3). MAML2 is a critical coactivator for NOTCH signaling. MAML2 associates with NOTCH and CSL in a ternary complex and functions to activate transcription of HES and hairy-related basic helix-loop-helix transcription factors. MAML2 has been identified in a chromosomal rearrangement and fusion with MECT1 in mucoepidermoid carcinomas, secondary acute myeloid leukemia, hidradenomas, and myelodysplastic syndrome. MECT1 is a CREB regulator, and when fused with the transactivational domain of MAML2, imparts constitutive activation of CREB-dependent transcription that may promote oncogenesis.
    基因ID
    84441
    UniProt
    Q8IZL2
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