anti-Interferon-Induced Transmembrane Protein 3 (IFITM3) 抗体

The protein encoded by IFITM3 is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. 再加上,我们可以发Interferon-Induced Transmembrane Protein 3 试剂盒 (13)Interferon-Induced Transmembrane Protein 3 蛋白 (5)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
IFITM3 66141 Q9CQW9
IFITM3 10410 Q01628
IFITM3 361673 P26376
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Showing 10 out of 75 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 IC, IF, WB Immunofluorescent analysis of IFITM3 staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Western blot analysis of IFITM3 expression in HEK293T (A), HeLa (B), Raw264.7 (C), H9C2 (D) whole cell lysates. 200 μL Log in to see 13至14个工作日
$487.50
详细
山羊 非结合性 ELISA, IHC, WB ABIN5539737 (0.5µg/ml) staining of HeLa lysate (35µg protein in RIPA buffer). Detected by chemiluminescence. 100 μg Log in to see 6至7个工作日
$429.84
详细
非结合性 IF, ELISA, WB Western blot analysis of extracts from HepG2/HeLa cells, using IFM3 Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of MCF7 cells, using IFM3 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2至3个工作日
$302.50
详细
山羊 非结合性 ELISA, IHC, WB ABIN5539738 (1µg/ml) staining of HeLa lysate (35µg protein in RIPA buffer). Detected by chemiluminescence. 100 μg Log in to see 6至7个工作日
$429.84
详细
非结合性 ELISA, IF, WB Western Blot (WB) analysis of specific cells using IFITM3 Polyclonal Antibody. 100 μL Log in to see Available
$181.73
详细
非结合性 IP, WB IFITM3 MaxPab rabbit polyclonal antibody. Western Blot analysis of IFITM3 expression in human placenta. IFITM3 MaxPab rabbit polyclonal antibody. Western Blot analysis of IFITM3 expression in HepG2. 100 μL Log in to see 11至12个工作日
$425.71
详细
非结合性 ELISA, ICC, IF, WB Western blot analysis IFITM3 using COLO205 whole cell lysates ABIN6278271 staining  HepG2 cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibod 100 μL Log in to see 11至12个工作日
$390.77
详细
非结合性 EIA, WB 0.4 mL Log in to see 6至8个工作日
$484.00
详细
非结合性 EIA, WB   0.4 mL Log in to see 4至8个工作日
$522.50
详细
非结合性 WB Western Blot analysis of IFITM3 expression in transfected 293T cell line by IFITM3 MaxPab polyclonal antibody.Lane 1: IFITM3 transfected lysate(14.60 KDa).Lane 2: Non-transfected lysate. IFITM3 MaxPab rabbit polyclonal antibody. Western Blot analysis of IFITM3 expression in human placenta. 100 μg Log in to see 11至12个工作日
$425.71
详细

引用最多的anti-Interferon-Induced Transmembrane Protein 3 抗体

  1. Human Monoclonal IFITM3 Primary Antibody for ELISA, WB - ABIN564524 : Fan, Peng, Zhou, Qiu, Tang, Sun, Wang, Li, Le, Xie et al.: Gene-expression profiling in Chinese patients with colon cancer by coupling experimental and bioinformatic genomewide gene-expression analyses: identification and validation of IFITM3 as a biomarker ... in Cancer 2008 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal IFITM3 Primary Antibody for WB - ABIN523801 : Jia, Pan, Ding, Rong, Liu, Geng, Qiao, Liang: The N-terminal region of IFITM3 modulates its antiviral activity by regulating IFITM3 cellular localization. in Journal of virology 2012 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal IFITM3 Primary Antibody for ELISA, WB - ABIN543322 : Tanaka, Yamaguchi, Tsoi, Lickert, Tam: IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion. in Developmental cell 2005 (PubMed)

  4. Human Polyclonal IFITM3 Primary Antibody for IHC, WB - ABIN6674953 : Luo, Huang, Luo, Liao, Wang, Deng, Ma, Ma, Zhou: Identification of genes underlying the enhancement of immunity by a formula of lentinan, pachymaran and tremelia polysaccharides in immunosuppressive mice. in Scientific reports 2018 (PubMed)

更多抗Interferon-Induced Transmembrane Protein 3的相互作用对抗体

Mouse (Murine) Interferon-Induced Transmembrane Protein 3 (IFITM3) interaction partners

  1. the role of IFITM3 in colonic epithelial homeostasis, inflammation and colitis-associated tumorigenesis using IFITM3-deficient mice, was investigated.

  2. The extracellular level of Fstl1 is regulated by Ifitm3 in astrocytes, which could be involved in polyI:C-induced neurodevelopmental impairment.

  3. contrary to its role in enhancing DNA virus replication, LSD1 limits RNA virus replication by demethylating and activating IFITM3 which is a host restriction factor for many RNA viruses

  4. IFITM1 and IFITM3 inhibit Zika virus infection early in the viral life cycle.

  5. ZMPSTE24 is a downstream effector of IFITM3 and is important for interferon-induced transmembrane antiviral activity.

  6. IFITM3 represents a checkpoint regulator of antiviral immunity that controls cytokine production to restrict viral pathogenesis.

  7. Collectively, the data define an antiviral role for Ifitm3 in restricting infection of multiple alphaviruses.

  8. Ifitm3 plays a role in mouse primordial germ cell homing and repulsion by enhancing the regionalization of PGCs.

  9. Ifitm3 does not impact on the restriction or pathogenesis of bacterial (Salmonella typhimurium, Citrobacter rodentium, Mycobacterium tuberculosis) or protozoan (Plasmodium berghei) pathogens, despite in vitro evidence.

  10. results suggest that modification of Tyr(20) may serve in a cellular checkpoint controlling IFITM3 trafficking and degradation and demonstrate the complexity of posttranslational regulation of IFITM3

  11. It acts as a defence factor for virus infection, though, it also suppress endocytosis of astroglia, which results in neurodevelopmental impairment.(review)

  12. Interferon-induced transmembrane protein 3 is a type II transmembrane protein.

  13. results revealed diverse, yet consistent, profiles of IFITM3 localization throughout the gastrula

  14. Induction of IFITM3 expression in astrocytes leads to brain dysfunction by impairing neurite development and other non-cell autonomous effects such as increasing mRNA levels of inflammatory cytokines.

  15. Jin Chai antiviral capsule exerts antiviral effects against influenza virus by raised expression of IFITM3.

  16. lung TRM cells were programmed to retain IFITM3 expression, which facilitated their survival and protection from viral infection during subsequent exposures

  17. A central role for Ifitm3 in limiting acute influenza in vivo.

  18. IFITM3 is essential for defending the host against influenza A virus in vivo; mice lacking Ifitm3 display fulminant viral pneumonia when challenged with a normally low-pathogenicity influenza virus, mirroring the destruction inflicted by the highly pathogenic 1918 'Spanish' influenza

  19. S-palmitoylation and ubiquitination differentially regulate interferon-induced transmembrane protein 3 (IFITM3)-mediated resistance to influenza virus.

  20. Specific deletion of KLF4 led to IFITM3 overexpression in colon mucosa in Villin-Cre+ ;Klf4 fl/fl mice.

Human Interferon-Induced Transmembrane Protein 3 (IFITM3) interaction partners

  1. The authors show that full-length IFITM3 mRNA is dominantly expressed (>99%) across all rs12252 genotypes.

  2. Role of IFITM3 in vaccinia virus infection was investigated at cellular level and observed that vaccinia virus did not trigger the transcription of IFITM3 or even down regulated IFITM3 expression by an IRF3-independent manner. Silencing of endogenous IFITM3 did not exert any significant effect on virus infection, but it regulated the antiviral activity of type Iota IFN and modulated the vaccinia virus-induced cell death.

  3. overexpression of IFITM1, 2 and 3 suppressed entry of CXCR4 and CCR5 tropic viruses; entry of transmitted founder HIV-1 in U87 cells is more sensitive to inhibition by IFITM2 and IFITM3 than by IFITM1

  4. The patients with HCC had a significantly higher proportion of IFITM3 rs12252-CC as compared with the patients with chronic HBV infection or liver cirrhosis. Moreover, the distribution of CC genotype in HCC patients with low differentiation was significantly higher than that in those with high differentiation. Furthermore, the patients with CC genotype were found with bigger tumor size.

  5. Study showed that IFITM3 was upregulated in hepatocellular carcinoma (HCC) tissues and associated with HCC tumor size, tumor multifocal, and venous invasion. Furthermore, IFITM3 was identified as a new functional target gene of miR29a which expression was negatively correlated with that of IFITM3 in HCC tissues. These results indicated that IFITM3 play a critical role in the development and progression of HCC.

  6. a functional convergence between the mTOR pathway and IFITM3 proteins at endolysosomal membranes.

  7. We analyzed the population genetics of IFITM3 variants in the Portuguese general population (n = 200) and Central Africans (largely Angolan) (n = 148) as well as its association to influenza severity in Portuguese patients

  8. rs12252 C polymorphism of interferon-induced transmembrane protein 3 (IFITM3) is associated mild flu in Iranian population. Carriers of the rs12252 C allele (CT + CC genotypes) showed 5.92 folds increase in the risk of mild flu comparing to the T allele homozygotes. There is a significant positive association between rs12252 C allele heterozygote and mild flu but not in C allele homozygote group.

  9. A significant association between the IFITM3 rs12252 polymorphism and the risk of influenza in both the White and East Asian populations (meta-analysis).

  10. contrary to its role in enhancing DNA virus replication, LSD1 limits RNA virus replication by demethylating and activating IFITM3 which is a host restriction factor for many RNA viruses

  11. study predicts IFITM3 secondary structures and identifes a highly conserved, short amphipathic helix within a hydrophobic region of IFITM3 previously thought to be a transmembrane domain; show this helix and its amphipathicity are required for IFITM3-dependent inhibition of influenza virus, Zika virus vesicular stomatitis virus, Ebola virus and HIV infections

  12. frequencies of the CC genotype and the C allele in the IFITM3 polymorphism were higher in the Korean population than in the European populations but not in Chinese and Japanese populations; the rs12252 polymorphism of the IFITM3 gene did not significantly correlate with the disease severity of influenza A virus infection

  13. IFITM3 rs12252 CC genotype was associated with severity rather than susceptibility of IVI in Chinese population, and this strong effect was observed in all subtypes of seasonal influenza infection

  14. Identification of three distinct mutations that converted IFITM1 or IFITM3 from inhibitors to enhancers of MERS-CoV or SARS-CoV spike protein-mediated entry revealed key structural motifs or residues determining the biological activities of IFITM proteins.

  15. Results demonstrate that IFITM3 expression has a close relationship with prognosis in esophageal squamous cell carcinoma (ESCC) patients. Its overexpression may predict poor prognosis in stage IIA ESCC patients after Ivor Lewis esophagectomy.

  16. Study demonstrated, for the first time, that IFITM3 is expressed at a much higher level in lung cancer than in control tissues. Its knockdown could suppress lung cancer cell proliferation, invasion, and migration while inducing lung cancer cell cycle arrest and apoptosis.

  17. IFITM3 is upregulated in patient-derivedbrain tumor-propagating cells (BTPCs) upon irradiation but does not affect brain tumor formation or progression in vivo.

  18. These results indicate that IFITM3 protein can restrict alphavirus infection by inhibiting viral fusion with cellular membranes.

  19. The transcriptional regulation of IFITM1, 2 and 3 expression.

  20. IFITM1 and IFITM3 inhibit Zika virus infection early in the viral life cycle.

Interferon-Induced Transmembrane Protein 3 (IFITM3) 抗原简介

蛋白简介

The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the full-length nature of this variant has not been determined.

Gene names and symbols associated with IFITM3

  • Interferon-induced transmembrane protein 3 (ifm3) 抗体
  • interferon induced transmembrane protein 3 (Ifitm3) 抗体
  • interferon induced transmembrane protein 3 (IFITM3) 抗体
  • 1-8U 抗体
  • 1110004C05Rik 抗体
  • Cd225 抗体
  • Cdw217 抗体
  • DSPA2b 抗体
  • Fgls 抗体
  • IP15 抗体
  • mil-1 抗体
  • rat8 抗体

Protein level used designations for IFITM3

Interferon-induced transmembrane protein 3 , dispanin subfamily A member 2b , fragilis protein , ifitm-like protein 1 , interferon-induced transmembrane protein 3 , interferon-inducible protein 15 , interferon-inducible protein 1-8U , interferon-inducible protein variant 10

GENE ID SPECIES
100305344 Oncorhynchus mykiss
66141 Mus musculus
10410 Homo sapiens
361673 Rattus norvegicus
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