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The protein encoded by HIPK1 belongs to the Ser/Thr family of protein kinases and HIPK subfamily. 再加上，我们可以发HIPK1 蛋白 (9)和数多这个蛋白质的别的产品。
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Mouse (Murine) Monoclonal HIPK1 Primary Antibody for ICC, IF - ABIN2668291
Isono, Nemoto, Li, Takada, Suzuki, Katsuki, Nakagawara, Koseki: Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals. in Molecular and cellular biology 2006
Analysis of these mutants revealed that HIPK1, HIPK2 (显示 HIPK2 抗体) and HIPK3 (显示 HIPK3 抗体) but not HIPK4 (显示 HIPK4 抗体) are capable of autophosphorylating on other tyrosines
PAGE4 (显示 PAGE4 抗体), a regulator of c-Jun (显示 JUN 抗体) transactivation, is phosphorylated by homeodomain-interacting protein kinase 1.
HIPK1 drives p53 (显示 TP53 抗体) activation to limit colorectal cancer cell growth.
HIPK1 and HIPK2 (显示 HIPK2 抗体), are transcriptional corepressors that regulate TGF-beta (显示 TGFB1 抗体)-dependent angiogenesis during embryonic development.
HIPK1 expression was identified only in invasive breast cancer cells with three different patterns: cytoplasmic, nuclear, and both cytoplasmic and nuclear.
These findings indicate that the control of HIPK1 stability by Mdm2 (显示 MDM2 抗体)-NORE1 (显示 RASSF5 抗体) has a major effect on cell behaviour, and epigenetic inactivation of NORE1 (显示 RASSF5 抗体) enables adenocarcinoma formation in vivo through HIPK1 stabilization.
TNFalpha (显示 TNF 抗体)-induced desumoylation and cytoplasmic translocation of HIPK1 are critical in TNFalpha (显示 TNF 抗体)-induced ASK1 (显示 MAP3K5 抗体)-JNK (显示 MAPK8 抗体)/p38 (显示 CRK 抗体) activation
c-Myb (显示 MYB 抗体) appears to be phosphorylated by HIPK1 in its negative regulatory domain as supported by both in vivo and in vitro data.
Therefore, our data confirm that the beta-Catenin (显示 CTNNB1 抗体) signaling plays a dual role in controlling cell proliferation/differentiation in the brain and indicate that Hipk1 is the crucial interactor able to revert the outcome of beta-Catenin (显示 CTNNB1 抗体) signaling in cells.
Despite the expanded marginal zone B cell population in the HIPK1(-/-) mice, the T-independent type 2 humoral response was impaired.
HIPK1 and Daxx (显示 DAXX 抗体) collaborate in regulating transcription.
characterization of cells and gene-targeted mice deficient for the p53 (显示 TP53 抗体)-binding kinase homeodomain-interacting protein kinase 1
The present study indicated the overlapping roles for Hipk1 and Hipk2 (显示 HIPK2 抗体) in mediating cell proliferation and apoptosis in response to morphogenetic and genotoxic signals during mouse development.
SENP1 (显示 SENP1 抗体) mediates TNF (显示 TNF 抗体)-induced desumoylation and translocation of HIPK1, leading to an enhanced ASK1 (显示 MAP3K5 抗体)-dependent apoptosis.
TNFalpha (显示 TNF 抗体)-induced desumoylation and cytoplasmic translocation of HIPK1 are critical in TNFalpha (显示 TNF 抗体)-induced ASK1 (显示 MAP3K5 抗体)-JNK (显示 MAPK8 抗体)/p38 (显示 MAPK14 抗体) activation
The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms.
homeodomain interacting protein kinase 1
, homeodomain-interacting protein kinase 1-like
, homeodomain-interacting protein kinase 1
, homeodomain interacting protein kinase 1-like protein
, nuclear body associated kinase 2b
, nuclear body-associated kinase 2
, protein kinase Myak