This gene encodes a luminal sarcoplasmic reticulum protein identified by its ability to bind low-density lipoprotein with high affinity. The protein interacts with the cytoplasmic domain of triadin, the main transmembrane protein of the junctional sarcoplasmic reticulum (SR) of skeletal muscle. The protein functions in the regulation of releasable calcium into the SR. [provided by RefSeq, Sep 2008].
Boncompagni, Thomas, Lopez, Allen, Yuan, Kranias, Franzini-Armstrong, Perez: "Triadin/Junctin double null mouse reveals a differential role for Triadin and Junctin in anchoring CASQ to the jSR and regulating Ca(2+) homeostasis." in: PLoS ONE, Vol. 7, Issue 7, pp. e39962, (2012) (PubMed).
Aliases for HRC 抗体
histidine rich calcium binding protein (HRC) 抗体 histidine rich calcium binding protein (Hrc) 抗体 DKFZp468J236 抗体