Hemoglobin, gamma G 蛋白 (HBG2)

The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. 再加上,我们可以发HBG2 试剂盒 (31)HBG2 抗体 (24)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
HBG2 3048 P69892
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Showing 7 out of 9 products:

产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
大肠杆菌(E. Coli) His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30至35个工作日
大肠杆菌(E. Coli) His tag 100 μg Log in to see 15至19个工作日
HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
酵母菌 REACT_Capuchin Monkey His tag   1 mg Log in to see 60至71个工作日
酵母菌 Pongo pygmaeus His tag   1 mg Log in to see 60至71个工作日
酵母菌 Chimpanzee His tag   1 mg Log in to see 60至71个工作日
大肠杆菌(E. Coli) 非结合性   100 μg Log in to see 11至18个工作日

HBG2 蛋白 by Origin and Source

Origin 在表达 标记
Human ,
Capuchin Monkey (Cebus)


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Human Hemoglobin, gamma G (HBG2) interaction partners

  1. Data suggest that studying genotype frequency of the Xmn1 gammaG globin polymorphism (-158C>T ) in Siwa Oasis, Egypt can be considered as a starting point for further research targeting this community sector.

  2. The results suggested that there was a significant relationship between high fetal hemoglobin levels and two variations (-309A/T and -369C/G) in Ggamma gene promotor.

  3. Genetic association studies provide a rationale for functional studies of HBG2 expression in wild-type and T/A/T haplotype erythroblasts and mechanistic studies like chromatin conformation capture experiments, to evaluate the role of chromatin looping as a mediator of the T/A/T haplotype effects on HbF.

  4. The frequency of rs7482144 was determined in Colombian sickle cell anemia patients. It indicated a West African ethnic background.

  5. In Portuguese beta-thalassemia carriers the HBG2 XmnI polymorphism is strongly associated with HbF levels.

  6. DNA polymorphisms at BCL11A, HBS1L-MYB and Xmn1-HBG2 site loci associated with fetal hemoglobin levels in sickle cell anemia patients from Northern Brazil.

  7. Its polymorphism effects HbF, HbE, MCV and MCH levels in Thai HbE carriers.

  8. Data indicate that the T to A conversion results in a leucine to histidine amino acid change at codon 105 of the (G)gamma-globin HBG2 gene and caused a hemoglobin (Hb) variant with lowered oxygen affinity.

  9. Hemoglobin gamma G plays a role in modifying clinical symptoms of beta-thalassemia innorthern Thailand.

  10. Data suggest that segregation of BCL11A haplotype 2 indicating an involvement of this locus in Hb F expression.

  11. Hb F is regulated in inherited bone marrow failure syndromes by Xmn1-HBG2, as it is in the haemoglobinopathies.

  12. Our data suggest that a temporal repression mechanism is operative in the silencing of gamma-globin gene expression

  13. results establish SATB2 as a novel gamma-globin gene regulator and provide a glimpse of the differential and cooperative roles of SATB family proteins in modulating clustered genes transcription

  14. the study demonstrated that Egyptian beta-thalessemia patients have low frequency of positivity for the Xmnl polymorphism whether in heterozygous (+/-) or homozygous (+/+) state

  15. although the prevalence of Xmn1-(G)gamma polymorphism is high in beta thalassemia intermedia patients, it alone could not predict clinical severity of disease

  16. Chromatin looping between the Ggamma-globin gene and LCR HSs requires NF-E2.

  17. We identified a missense mutation in the fetal Ggamma-globin gene (HBG2) in a father and daughter with transient neonatal cyanosis and anemia.

  18. 12 molecules in the unit cell describe a right-handed helical filament having no polarity, which is different from the filament composed of HbS fibers, which is the only other well characterized fiber of human hemoglobin

  19. The polymorphisms -396_-391 del HBG2, -369 SNP HBG2 and -271 SNP HBG1 correlated with HbF levels, hence, it suggests an important role of HBG2 and HBG1 gene polymorphisms on the HbF synthesis.

  20. The recently identified chromatin factor Friend of Prmt1 (FOP) is a critical modulator of gamma-globin gene expression.



The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'- epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.

Gene names and symbols associated with Hemoglobin, gamma G 蛋白 (HBG2)

  • hemoglobin subunit gamma 2 (HBG2)
  • hemoglobin subunit gamma 2 (hbg2)
  • hemoglobin subunit gamma 2 L homeolog (hbg2.L)
  • hemoglobin, gamma G (HBG2)
  • hemoglobin subunit gamma 2 S homeolog (hbg2.S)
  • hbb2 蛋白
  • HBG 蛋白
  • MGC88976 蛋白
  • TNCY 蛋白

Protein level used designations for Hemoglobin, gamma G 蛋白 (HBG2)

G-gamma globin Paulinia , abnormal hemoglobin , gamma-2-globin , hb F Ggamma , hemoglobin gamma-2 chain , hemoglobin gamma-G chain , hemoglobin subunit gamma-2 , methemoglobin , hemoglobin, gamma G , G-gamma globin , Gamma-globin , Hemoglobin beta-3 , Hemoglobin gamma chain , beta-3 globin , hemoglobin subunit gamma , B2G , beta-2-globin , hemoglobin beta-2 chain , hemoglobin beta-minor chain , hemoglobin subunit beta-2 , larval beta II globin , larval beta-II-globin

3048 Homo sapiens
448249 Xenopus (Silurana) tropicalis
100381042 Xenopus laevis
100328858 Oryctolagus cuniculus
397871 Xenopus laevis
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