anti-Gap Junction Protein, alpha 8, 50kDa (GJA8) 抗体

GJA8 encodes a transmembrane connexin protein that is necessary for lens growth and maturation of lens fiber cells. 再加上,我们可以发Gap Junction Protein, alpha 8, 50kDa 蛋白 (7)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
GJA8 14616 P28236
GJA8 29601  
GJA8 2703 P48165
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antibodies-online.cn销售最多的anti-Gap Junction Protein, alpha 8, 50kDa 抗体

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产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 WB WB Suggested Anti-GJA8 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  HepG2 cell lysate 100 μL Log in to see 2至3个工作日
Cow 非结合性 WB WB Suggested Anti-Gja8 Antibody Titration:  0.2-1 ug/ml  Positive Control:  Mouse Uterus Host:  Rat  Target Name:  GJA8  Sample Tissue:  Rat Skeletal Muscle  Antibody Dilution:  1ug/ml 100 μL Log in to see 2至3个工作日
山羊 非结合性 ELISA   100 μg Log in to see 6至7个工作日
非结合性 IHC (p), WB Western blot analysis of anti-GJA8 Antibody (C-term) (ABIN388381) in mouse kidney tissue lysates (35 µg/lane). GJA8 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10至11个工作日
非结合性 EIA, IHC (p), WB 0.4 mL Log in to see 6至8个工作日
非结合性 WB 50 μg Log in to see 11至14个工作日
Cow 非结合性 WB 50 μg Log in to see 11至14个工作日
山羊 非结合性 ELISA   0.1 mg Log in to see 2至3个工作日
非结合性 WB Western blot analysis of anti-GJA8 Antibody in HepG2 cell line lysates (35ug/lane) 400 μL Log in to see 2至3个工作日
山羊 非结合性 ELISA   100 μg Log in to see 11至14个工作日

引用最多的anti-Gap Junction Protein, alpha 8, 50kDa 抗体

  1. Human Polyclonal GJA8 Primary Antibody for WB - ABIN1882072 : Shiels, Mackay, Ionides, Berry, Moore, Bhattacharya: A missense mutation in the human connexin50 gene (GJA8) underlies autosomal dominant "zonular pulverulent" cataract, on chromosome 1q. in American journal of human genetics 1998 (PubMed)
    Show all 4 Pubmed References

  2. Cow (Bovine) Polyclonal GJA8 Primary Antibody for ELISA - ABIN4264873 : Lin, Liu, Lei, Fan, Liu, Yang, Wang, Liu, Yang: [A novel GJA8 mutation in a Chinese family with autosomal dominant congenital cataract]. in Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 2008 (PubMed)

更多抗Gap Junction Protein, alpha 8, 50kDa的相互作用对抗体

Mouse (Murine) Gap Junction Protein, alpha 8, 50kDa (GJA8) interaction partners

  1. These results suggest that expression of Cx50D47A induces ER stress, triggering activation of the PERK-ATF4 pathway, which potentially contributes to the lens pathology and leads to increased expression of anti-apoptotic factors, allowing cell survival.

  2. Study showed that mouse horizontal cells establish a coupled dendritic network by Cx57 and two coupled axon terminal networks, one made of Cx50 and the other made of Cx57 channels

  3. data show that expression and phosphorylation of Cx46 and Cx50 are complementary in seminiferous tubules

  4. demonstrate, at the whole gap junction channel level, a crucial role of the surface charge properties in the first transmembrane/first extracellular border domain in determining the efficiency of ion permeation and the Vj gating of Cx50

  5. Data show that Ca(V) 1.2 and 1.3 channels are expressed in lens, regulating phosphorylation of aquaporin-0 and myosin light chain and expression of connexins 50 and 46.

  6. The Gja8(R205G) mutation differentially impairs the functions of Cx50 and Cx46 to cause cataracts, small lenses and microphthalmia.

  7. D3 residue plays an essential role in unitary conductance of Cx50 gap junction channels

  8. Normal Cx50 function requires an intact PDZ domain-binding motif.

  9. These results showed that the binding of calcium/calmodulin to the intracellular loop of connexin 50 (Cx50) is critical for mediating the Ca2+-dependent inhibition of Cx50 gap junctions

  10. Dense cataract and microphthalmia (dcm) in BALB/c mice is caused by mutations in the GJA8 gene.

  11. The N terminus of Cx50 is critical for both the V(j)-gating and the gamma(j), and the introduction of a positively charged Arg at the ninth position reduced the G(min) with a correlated disappearance of the substate at the single channel level.

  12. alpha8 connexin is required for proper fiber cell maturation and control of lens size

  13. intrinsic properties of Cx50 are required for cellular growth of lens cells

  14. Cx50-mediated communication is necessary to achieve peak mitosis. Possible novel mitogenic role for gap junctional coupling, connexin specific and independent of MAPK signaling.

  15. The hypothesis that the way in which V(j) gating reacts to CO(2) might be related to connexin 50 gating polarity is confirmed here.

  16. Results indicates connexin 50 expressed alone are recruited into different lipid environments and interaction of connexins and MP26 contributes to the overall organization of the fiber cells.

  17. a cross-talk between CFTR and a variety of gap junction channels. Cytoskeletal scaffolding proteins and/or other intermediate cytoplasmic proteins are likely to play a role in CFTR-connexins interaction.

  18. The cataract-inducing S50P mutation in Cx50 dominantly alters the channel gating of wild-type lens connexins.

  19. MAPK signaling specifically modulates coupling mediated by Cx50 and that gap junctional communication and signal transduction pathways may interact in osmotic regulation during postnatal fiber development.

  20. These data suggest that dominant inhibition of Cx43 mediated epithelial cell coupling may play a role in the lens pathophysiology caused by the Cx50-S50P mutation.

Human Gap Junction Protein, alpha 8, 50kDa (GJA8) interaction partners

  1. Together, these results suggest that in addition to forming gap junction channels, Cx50 acts as an adhesive molecule that is critical in maintaining lens fiber integrity and epithelial-fiber differentiation.

  2. this study identified the genetic susceptibility of GJA8 polymorphisms on ARC and provides new clues for fully understanding the pathological mechanism of GJA8 variants in affecting lens opacity

  3. The mutation c.139G>A in the GJA8 gene detected in the present study was also previously reported in Caucasian and Chinese families but with different phenotypes, i.e. nuclear and nuclear pulverulent cataracts. Thus, the mutation c.139G>A in GJA8 appears to exhibit marked interfamilial phenotypic variability.

  4. The p.V44M mutation in the GJA8 gene was the most common mutation and was due to a founder effect within the Chinese congenital cataract cohort studied.

  5. GJA8 is the newly identified genetic cause of familial congenital cataract.

  6. Data indicate de novo heterozygous mutations affecting the same codon of gap junction alpha-8 protein (GJA8) p.(Gly94Glu) and p.(Gly94Arg) )in 2 of the probands, in addition to the p.(Asp51Asn) mutation previously identified in the third case.

  7. Study identified two novel missense mutations within P59 and R76 of Cx50 that are associated with autosomal dominant congenital cataracts (ADCC). Functional analysis showed that Cx50R76H localized at appositional membranes forming gap junctions with enormous cytoplasmic protein accumulation, whereas the Cx50P59A mutation was found inefficient at forming detectable plaques.

  8. The novel insert mutation in the TM2 domain of Cx50 protein, which impairs its trafficking to the cell membrane and gap-junction function, is associated with the cataract formation in this Chinese pedigree.

  9. study demonstrates that the mutant protein localized to the plasma membrane and formed functional intercellular channels. These data suggest that GJA8 c.658A>G is most likely a benign rare variant

  10. The missense mutation c.139G > A in GJA8 gene is associated with autosomal dominant congenital cataract in a six-generation Chinese family. The result of this present study provides further evidence that the p. D47N mutation in CX50 is a hot-spot mutation.

  11. The c.433G > T (p.G145W) mutation in the GJA8 gene was first reported to our best knowledge. The results of our study would further broaden the mutation spectrum of GJA8 associated with congenital cataract.

  12. the role of the charged residues at the end of TM-1 in voltage sensing in Cx26, Cx46, and Cx50.

  13. This study identified three mutations in three Chinese families with hereditary cataracts. Of the three mutations, two were novel (c.125 A > C in GJA3 and c.268 C > T in GJA3), one was previously reported (c.218 C > T in GJA8).

  14. These results indicated that the mutant Cx50 (S276F) might inhibit the function of gap junction channel in a dominant negative manner, but inhibit the hemichannel function in a recessive negative manner.

  15. GJA8 mutation (p.V44A) is associated with autosomal dominant congenital cataract.

  16. This is a novel missense mutation [c.829C > T, (p.H277Y)] identified in exon 2 of Cx50.

  17. We have used trio-based exome sequencing to uncover a recurrent missense mutation in CRYGD and two novel missense mutations in GJA8 associated with autosomal dominant cataract in three nuclear families.

  18. Tthe molecular consequences of the p.P88T mutation in GJA8 include changes in connexin 50 protein localization patterns.

  19. A recurrent missense mutation c.773C>T (p.S258F) in exon 2 of the gap junction protein alpha 8 gene (GJA8) was identified in the proband with nuclear cataract.

  20. structural bases of the varied functional consequences of Cx50 missense mutations, were determined.

Gap Junction Protein, alpha 8, 50kDa (GJA8) 抗原简介


This gene encodes a transmembrane connexin protein that is necessary for lens growth and maturation of lens fiber cells. The encoded protein is a component of gap junction channels and functions in a calcium and pH-dependent manner. Mutations in this gene have been associated with zonular pulverulent cataracts, nuclear progressive cataracts, and cataract-microcornea syndrome.

Gene names and symbols associated with GJA8

  • gap junction protein, alpha 8 (Gja8) 抗体
  • gap junction protein alpha 8 (GJA8) 抗体
  • Aey5 抗体
  • CAE 抗体
  • CAE1 抗体
  • Cnx50 抗体
  • CTRCT1 抗体
  • Cx45.6 抗体
  • CX50 抗体
  • CZP1 抗体
  • Lop10 抗体
  • MP70 抗体

Protein level used designations for GJA8

alpha 8 connexin , connexin-50 , gap junction alpha-8 protein , gap junction membrane channel protein alpha 8 , lens fiber protein MP70 , lens opacity 10 , connexin 50 , cell surface glycoprotein , gap junction membrane channel protein alpha-8 , lens intrinsic membrane protein MP70 , connexin 45.6 , connexin-45.6 , MP38 , MP64 , connexin-49 , cx49

14616 Mus musculus
29601 Rattus norvegicus
2703 Homo sapiens
395846 Gallus gallus
100170231 Ovis aries
483156 Canis lupus familiaris
524042 Bos taurus
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