Deoxyribonuclease II, Lysosomal 蛋白 (DNASE2)

DNASE2 encodes a member of the DNase family. 再加上,我们可以发Deoxyribonuclease II, Lysosomal 抗体 (53)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
DNASE2 13423 P56542
DNASE2 1777 O00115
DNASE2 171575 Q9QZK8
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DNASE2 蛋白 by Origin and Source

Origin 在表达 标记
Mouse (Murine)

Human , , ,
, , ,
Rat (Rattus)

更多Deoxyribonuclease II, Lysosomal (DNASE2)互动伙伴

Fruit Fly (Drosophila melanogaster) Deoxyribonuclease II, Lysosomal (DNASE2) interaction partners

  1. These results confirm that DNase II and the ability to clear macromolecular DNA is essential for maintaining proper immune function in Drosophila.

  2. findings indicate that DNaseII can act cell autonomously to degrade DNA during nonapoptotic cell death.

Mouse (Murine) Deoxyribonuclease II, Lysosomal (DNASE2) interaction partners

  1. holocrine secretion is a DNase2-mediated form of programmed cell death and suggest that autophagy-dependent metabolism, DNA degradation

  2. Data show that Klf1 (显示 KLF1 蛋白) is expressed in central macrophagse of erythroblastic islands and that it binds and activates the promoter of Dnase2a.

Human Deoxyribonuclease II, Lysosomal (DNASE2) interaction partners

  1. Study identifies biallelic mutations in DNASE2, associated with a loss of DNase II endonuclease activity causing type I interferonopathy in three patients from two unrelated families.

  2. Single nucleotide polymorphisms producing a loss-of-function variant of the enzymes in DNASE1 (显示 DNASE1 蛋白), DNASE1L3 (显示 DNASE1L3 蛋白), and DNASE2, possibly serving as a genetic risk factor for autoimmune diseases, were confirmed.

  3. 15 nonsynonymous human DNase II SNPs were genotyped in three ethnic groups including 16 different populations using the PCR-restriction fragment length polymorphism technique.

  4. study demonstrated the relationship of genotypes/haplotypes with the in vivo DNase II and promoter activities; significant correlations between genotype in each rheumatoid arthritis (RA)-related SNP and enzymatic activity levels were found; alleles associated with RA exhibited a reduction in serum DNase II activity.

  5. upregulation of expression during myelomonocytic differentiation of HL-60 and THP-1 cells

  6. Sp1 and Sp3 are involved in up-regulation of this enzyme's transcriptoin during cell differentiation of hl-60 cells.

  7. the enzyme is a monomeric phospholipase D-family member with a pseudodimeric protein fold

  8. The association of SNPs in the 5'-regulatory region of the DNA degrading enzyme DNASE2 with Rheumatoid Arthritis implies a role for this enzyme in the pathogenesis of this autoimmune disease.

Pig (Porcine) Deoxyribonuclease II, Lysosomal (DNASE2) interaction partners

  1. Proteolytic processing of porcine deoxyribonuclease II occurs in lysosomes but is not required for enzyme activation

  2. Data showed an association between PARP-1 and LEI/L-DNase II.

蛋白简介Deoxyribonuclease II, Lysosomal (DNASE2)

蛋白简介

This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record.

Gene names and symbols associated with DNASE2

  • Deoxyribonuclease II (DNaseII)
  • deoxyribonuclease II, lysosomal L homeolog (dnase2.L)
  • deoxyribonuclease 2, lysosomal (DNASE2)
  • deoxyribonuclease II, lysosomal (dnase2)
  • deoxyribonuclease II (dnase2)
  • deoxyribonuclease II alpha (Dnase2a)
  • deoxyribonuclease 2, lysosomal (Dnase2)
  • CG7780 蛋白
  • DDBDRAFT_0188966 蛋白
  • DDBDRAFT_0252883 蛋白
  • DDB_0188966 蛋白
  • DDB_0252883 蛋白
  • dDNase II 蛋白
  • Dmel\\CG7780 蛋白
  • DNase 蛋白
  • DNase-1 蛋白
  • DNase1 蛋白
  • DNase 1 蛋白
  • Dnase2 蛋白
  • Dnase2a 蛋白
  • DNL 蛋白
  • DNL2 蛋白
  • fa92d01 蛋白
  • LOC733868 蛋白
  • MGC80103 蛋白
  • wu:fa56d08 蛋白
  • wu:fa92d01 蛋白

Protein level used designations for DNASE2

deoxyribonuclease II , CG7780-PA , DNaseII-PA , acid DNase , deoxyribonuclease 1 , deoxyribonuclease II, lysosomal , deoxyribonuclease-2-alpha , fa56d08 , DNase II alpha , lysosomal DNase II , DNase II, lysosomal , R31240_2 , deoxyribonuclease II alpha

GENE ID SPECIES
48228 Drosophila melanogaster
446506 Xenopus laevis
476697 Canis lupus familiaris
733868 Xenopus (Silurana) tropicalis
747576 Pan troglodytes
100000399 Danio rerio
100171654 Pongo abelii
100599185 Nomascus leucogenys
8627734 Dictyostelium discoideum AX4
13423 Mus musculus
1777 Homo sapiens
171575 Rattus norvegicus
282218 Bos taurus
397398 Sus scrofa
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