anti-DIRAS Family, GTP-Binding RAS-Like 3 (DIRAS3) 抗体

DIRAS3 is a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but not in ovarian and breast cancers. 再加上,我们可以发DIRAS3 蛋白 (5)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
DIRAS3 9077 O95661
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Showing 10 out of 46 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 FACS, IHC (p), WB DIRAS3 Antibody (ABIN652072) western blot analysis in WiDr cell line lysates (35 µg/lane). This demonstrates the DIRAS3 antibody detected the DIRAS3 protein (arrow). DIRAS3 Antibody (ABIN652072) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10至11个工作日
非结合性 ELISA, IHC, IHC (p), WB Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 11至14个工作日
小鼠 非结合性 IP, ELISA, WB 100 μg Log in to see 11至14个工作日
非结合性 IHC, WB Western blot analysis of extracts of various cells, using DIRAS3 antibody. 100 μL Log in to see 11至13个工作日
非结合性 ELISA, IHC, WB Western blot analysis of DIRAS3 expression in 293 lysate,The lane on the left is treated with the antigen-specific peptide. ABIN6273354 at 1/100 staining Human liver cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL Log in to see 11至12个工作日
非结合性 IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Anti-ARHI Polyclonal Antibody, Unconjugated (ABIN681448) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3至7个工作日
非结合性 IHC, IHC (p), WB Immunohistochemistry-Paraffin: DIRAS3 Antibody [NBP1-90105] - Immunohistochemical staining of human cerebellum shows strong nuclear positivity in purkinje cells. Western Blot: DIRAS3 Antibody [NBP1-90105] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Negative control (vector only transfected HEK293T lysate).Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY401484) 0.1 mL Log in to see 10至13个工作日
非结合性 ELISA, WB   0.1 mg Log in to see 2至3个工作日
非结合性 WB Western blot analysis of extracts of various cell lines, using DIRAS3 antibody. 200 μL Log in to see 12至14个工作日
小鼠 非结合性 ELISA, WB Western Blot analysis of DIRAS3 expression in transfected 293T cell line by DIRAS3 monoclonal antibody (M01A), clone 1G4.Lane 1: DIRAS3 transfected lysate (Predicted MW: 25.9 KDa).Lane 2: Non-transfected lysate. Western Blot detection against Immunogen (36.74 KDa) . 200 μL Log in to see 11至12个工作日

引用最多的anti-DIRAS3 抗体

  1. Human Polyclonal DIRAS3 Primary Antibody for ELISA, WB - ABIN563932 : Li, Ramani, Sun, Zee, Grant, Yang, Xia, Oh, Ko, Mato, Lu: Forced expression of methionine adenosyltransferase 1A in human hepatoma cells suppresses in vivo tumorigenicity in mice. in The American journal of pathology 2010 (PubMed)


Pig (Porcine) DIRAS Family, GTP-Binding RAS-Like 3 (DIRAS3) interaction partners

  1. polymorphism-based approach was used to detect the imprinting status of NNAT and DIRAS3 genes in five heterozygous pigs (based on SNP) of Large White and Meishan F(1) hybrids

Human DIRAS Family, GTP-Binding RAS-Like 3 (DIRAS3) interaction partners

  1. Somatic Mutation of ARHI Gene in Hepatocellular Carcinomas.

  2. Low DIRAS3 expression is associated with metastasis in gastric cancer.

  3. lncRNA GAS5 functions as a competing endogenous RNA for miR-221 to suppress cell growth and EMT in osteosarcoma by regulating the miR-221/ARHI pathway.

  4. DiRas3 binds to KSR1 independently of its interaction with activated Ras and RAF.

  5. We demonstrate that DIRAS3 knock-down (KD) in adipose stromal/progenitor cells (ASCs) induces activation of Akt-mTOR signaling and proliferation arrest. DIRAS3 KD ASCs lose the potential to form colonies and are negative for Ki-67. Moreover, silencing of DIRAS3 results in a premature senescence phenotype.

  6. ARHI-mediated up-regulation of glycolysis and glutaminolysis was found to be autophagy-dependent and inhibition of these metabolic pathways resulted in decreased cell viability.

  7. The overexpression of ARHI promotes colon cancer SW480 cell apoptosis by inhibiting the level of Akt.

  8. Transcriptional, but not post-transcriptional, silencing of GNG12-AS1 causes concomitant upregulation of DIRAS3, indicating a function in transcriptional interference.

  9. ARHI mRNA and protein expression is markedly decreased in osteosarcoma MG-63 cells lines. Overexpression of ARHI inhibits cell viability and proliferation.

  10. ARHI-mediated autophagy-associated cell death enhances chemosensitivity to cisplatin in ovarian cancer cell lines and xenografts.

  11. EZH2-''induced H3K27me3 is associated with epigenetic repression of the ARHI tumor-suppressor gene in epithelial ovarian cancer

  12. ARHI competes with RanGTPase and interacts with importin beta via basic-acidic patch interaction, which leads to inhibition of STAT3 translocation.

  13. Letter: ARHI suppresses pancreatic cancer by regulating ERK 1/2 signaling.

  14. JMJD2A-dependent silencing of Sp1 in advanced breast cancer promotes metastasis by downregulation of DIRAS3.

  15. suggest that DIRAS3 not only regulates the autophagosome initiation complex, but induces autophagy in dormant, nutrient-deprived ovarian cancer cells that remain after conventional chemotherapy, facilitating their survival

  16. ARHI is required for autophagy-meditated cancer cell arrest and ARHI inhibits signaling through PI3K/AKT and Ras/MAP by enhancing internalization and degradation of the epidermal growth factor receptor.

  17. The silence of ARHI expression in vitro seems to accelerate the malignant transformation of healthy ovarian cells by restraining apoptosis and autophagy.

  18. ARHI acts as a tumor suppressor gene in MDA-MB-231 cells and, although trichostatin A+5-aza-2'-deoxycytidine can block the cells at different cell cycle phase, the antitumor effect is ARHI-dependent.

  19. Loss of ARHI expression is associated with glioma.

  20. ARHI acts as a tumor suppressor by downregulating the NFkappaB signaling pathway, which results in the inhibition of cell proliferation, apoptosis and the cell cycle in the pancreatic tumor PANC-1 cell line

DIRAS3 抗原简介


This gene is a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but not in ovarian and breast cancers. It is an imprinted gene, with monoallelic expression of the paternal allele, which is associated with growth suppression. Thus, this gene appears to be a putative tumor suppressor gene whose function is abrogated in ovarian and breast cancers.

Gene names and symbols associated with DIRAS3

  • DIRAS family GTPase 3 (DIRAS3) 抗体
  • DIRAS family GTP binding RAS like 3 (diras3) 抗体
  • ARHI 抗体
  • DIRAS3 抗体
  • NOEY2 抗体

Protein level used designations for DIRAS3

DIRAS family, GTP-binding RAS-like 3 , GTP-binding protein Di-Ras3 , GTP-binding RAS-like protein 3 , distinct subgroup of the Ras family member 3 , ras homolog gene family, member I , rho-related GTP-binding protein RhoI

456930 Pan troglodytes
504559 Bos taurus
701273 Macaca mulatta
733668 Sus scrofa
100135197 Xenopus (Silurana) tropicalis
100147791 Ovis aries
9077 Homo sapiens
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