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DIRAS3 is a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but not in ovarian and breast cancers. 再加上，我们可以发DIRAS3 蛋白 (5)和数多这个蛋白质的别的产品。
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Human Polyclonal DIRAS3 Primary Antibody for ELISA, WB - ABIN563932
Li, Ramani, Sun, Zee, Grant, Yang, Xia, Oh, Ko, Mato, Lu: Forced expression of methionine adenosyltransferase 1A in human hepatoma cells suppresses in vivo tumorigenicity in mice. in The American journal of pathology 2010
polymorphism-based approach was used to detect the imprinting status of NNAT (显示 NNAT 抗体) and DIRAS3 genes in five heterozygous pigs (based on SNP) of Large White and Meishan F(1) hybrids
Low DIRAS3 expression is associated with metastasis in gastric cancer.
lncRNA GAS5 functions as a competing endogenous RNA for miR (显示 MLXIP 抗体)-221 to suppress cell growth and EMT (显示 ITK 抗体) in osteosarcoma by regulating the miR (显示 MLXIP 抗体)-221/ARHI pathway.
DiRas3 binds to KSR1 (显示 KSR1 抗体) independently of its interaction with activated Ras and RAF (显示 RAF1 抗体).
We demonstrate that DIRAS3 knock-down (KD) in adipose stromal/progenitor cells (ASCs) induces activation of Akt (显示 AKT1 抗体)-mTOR (显示 FRAP1 抗体) signaling and proliferation arrest. DIRAS3 KD ASCs lose the potential to form colonies and are negative for Ki-67 (显示 MKI67 抗体). Moreover, silencing of DIRAS3 results in a premature senescence phenotype.
ARHI-mediated up-regulation of glycolysis and glutaminolysis was found to be autophagy-dependent and inhibition of these metabolic pathways resulted in decreased cell viability.
The overexpression of ARHI promotes colon cancer SW480 cell apoptosis by inhibiting the level of Akt (显示 AKT1 抗体).
Transcriptional, but not post-transcriptional, silencing of GNG12-AS1 (显示 PTGDR 抗体) causes concomitant upregulation of DIRAS3, indicating a function in transcriptional interference.
ARHI mRNA and protein expression is markedly decreased in osteosarcoma MG-63 cells lines. Overexpression of ARHI inhibits cell viability and proliferation.
ARHI-mediated autophagy-associated cell death enhances chemosensitivity to cisplatin in ovarian cancer cell lines and xenografts.
EZH2 (显示 EZH2 抗体)-''induced H3K27me3 is associated with epigenetic repression of the ARHI tumor-suppressor gene in epithelial ovarian cancer
This gene is a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but not in ovarian and breast cancers. It is an imprinted gene, with monoallelic expression of the paternal allele, which is associated with growth suppression. Thus, this gene appears to be a putative tumor suppressor gene whose function is abrogated in ovarian and breast cancers.
DIRAS family, GTP-binding RAS-like 3
, GTP-binding protein Di-Ras3
, GTP-binding RAS-like protein 3
, distinct subgroup of the Ras family member 3
, ras homolog gene family, member I
, rho-related GTP-binding protein RhoI