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DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. 再加上，我们可以发DDX21 蛋白 (5) 和 和数多这个蛋白质的别的产品。
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Cow (Bovine) Polyclonal DDX21 Primary Antibody for WB - ABIN2775198
Henning, So, Jin, Lau, Valdez: Silencing of RNA helicase II/Gualpha inhibits mammalian ribosomal RNA production. in The Journal of biological chemistry 2003
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Horse (Equine) Polyclonal DDX21 Primary Antibody for WB - ABIN2775197
Yang, Henning, Valdez: Functional interaction between RNA helicase II/Gu(alpha) and ribosomal protein L4. in The FEBS journal 2005
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Human Polyclonal DDX21 Primary Antibody for ChIP, ICC - ABIN4304615
Obrdlik, Louvet, Kukalev, Naschekin, Kiseleva, Fahrenkrog, Percipalle: Nuclear myosin 1 is in complex with mature rRNA transcripts and associates with the nuclear pore basket. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010
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Human Polyclonal DDX21 Primary Antibody for ICC, IF - ABIN151240
Song, Hotz-Wagenblatt, Voit, Grummt: SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops and safeguard genome stability. in Genes & development 2017
Human Polyclonal DDX21 Primary Antibody for WB - ABIN1539008
Smith, Krumpelbeck, Jegga, Prell, Matrka, Kappes, Greis, Ali, Meetei, Wells: The nuclear DEK interactome supports multi-functionality. in Proteins 2018
Knockdown of SIRT7 (显示 SIRT7 抗体) leads to the same phenotype as depletion of DDX21 (i.e., increased formation of R loops and DNA double-strand breaks), indicating that SIRT7 (显示 SIRT7 抗体) and DDX21 cooperate to prevent R-loop accumulation, thus safeguarding genome integrity.
DDX21 can suppress the expression of proteins with G4 qudruplexes in the 3 UTR (显示 UTS2R 抗体) of its mRNA.
Results report the biogenesis and function of a box H/ACA snoRNA-ended sno-lncRNA, referred to SLERT (snoRNA-ended lncRNA enhances pre-ribosomal RNA transcription). SLERT is different from Prader-Willi Syndrome (PWS) sno-lncRNAs and plays a crucial role in rRNA biogenesis by dislodging a previously unknown clamp of DDX21 ring-shaped arrangements on Pol I complexes, thereby liberating Pol I for active rRNA transcription.
In dengue virus infected cells, DDX21 translocates from nucleus to cytoplasm to active the innate immune response and thus inhibits DENV replication in the early stages of infection.
DDX21 expression in breast cancer cells can promote AP-1 (显示 FOSB 抗体) activity and rRNA processing, and thus, promote tumorigenesis by two independent mechanisms.
Identification of several late-acting snoRNAs that bind pre-40S particles in human cells and show that their association and function in pre-40S complexes is regulated by the RNA helicase (显示 DDX46 抗体) DDX21.
results uncover the multifaceted role of DDX21 in multiple steps of ribosome biogenesis, and provide evidence implicating a mammalian RNA helicase (显示 DDX46 抗体) in RNA modification and Pol II (显示 Pol II 抗体) elongation control
As sequential interaction of PB1 and NS1 with DDX21 leads to temporal regulation of viral gene expression, influenza A virus likely uses the DDX21-NS1 interaction not only to overcome restriction, but also to regulate the viral life cycle.
Data indicate that DDX21, a nucleolar protein (显示 MCRS1 抗体), was confirmed to associate with SET8 (显示 SETD8 抗体).
Studies indicated that DDX21, HNRNPC (显示 HNRNPC 抗体), and RCC2 (显示 RCC2 抗体) were isolated from Ku86 (显示 XRCC5 抗体) multicomponent complex in response to DNA damage.
TLR4 (显示 TLR4 抗体)/NF-kappaB (显示 NFKB1 抗体)-responsive microRNAs and their potential target genes: a mouse model of skeletal muscle ischemia-reperfusion injury.
a previously unknown function of the DDX21-TRIF (显示 RNF138 抗体)-S100A9 (显示 S100A9 抗体)-TLR4 (显示 TLR4 抗体)-MyD88 (显示 MYD88 抗体) signaling network in regulating inflammation during infection.
DDX1 (显示 DDX1 抗体)-DDX21-DHX36 (显示 DHX36 抗体) complex represents a dsRNA sensor that uses the TRIF (显示 RNF138 抗体) pathway to activate type I IFN responses in the cytosol of myeloid dendritic cells
RNA helicase II (显示 ATRX 抗体)/Gualpha silencing inhibits mammalian ribosomal RNA production
in addition to its transcriptional effects, c-Jun (显示 JUN 抗体) regulates rRNA processing and nucleolar compartmentalization of the rRNA processing protein DDX21
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription.
DEAD (Asp-Glu-Ala-Asp) box polypeptide 21
, RNA helicase II/Gu
, novel GUCT (NUC152) domain containing DEAD/DEAH box helicase
, nucleolar RNA helicase 2
, DEAD box protein 21
, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 21
, Gu protein
, RH II/Gu
, RNA helicase II/Gu alpha
, nucleolar RNA helicase Gu
, nucleolar RNA helicase II
, DEAD (Asp-Glu-Ala-Asp) box polypeptide 21a
, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 21 (RNA helicase II/Gu)