anti-DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 21 (DDX21) 抗体

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. 再加上,我们可以发DDX21 蛋白 (5)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
DDX21 9188 Q9NR30
DDX21 317399 Q3B8Q1
DDX21 56200 Q9JIK5
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antibodies-online.cn销售最多的anti-DDX21 抗体

Showing 10 out of 70 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 WB WB Suggested Anti-DDX21 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:12500  Positive Control:  HepG2 cell lysate DDX21 is supported by BioGPS gene expression data to be expressed in HepG2 Rabbit Anti-DDX21 antibody   Paraffin Embedded Tissue: Human Lung cell Cellular Data: cilia of renal tubule Antibody Concentration: 4.0-8.0 ug/ml Magnification: 400X 100 μL Log in to see 2至3个工作日
Cow 非结合性 WB WB Suggested Anti-DDX21 Antibody Titration:  1.25ug/ml  ELISA Titer:  1:1562500  Positive Control:  HepG2 cell lysate DDX21 is supported by BioGPS gene expression data to be expressed in HepG2 100 μL Log in to see 2至3个工作日
非结合性 ICC, IF, IHC, IHC (p), IP, WB Detection of Human DDX21 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate (5, 15 and 50 mcg for WB, 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-DDX21 antibody ABIN151240 used for WB at 0.04 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate. DDX21 was also immunoprecipitated using rabbit anti-DDX21 antibodies ABIN151238 and ABIN151239 at 3 mcg/mg lysate. Detection: Chemiluminescence with exposure times of 10 seconds (A) and 3 seconds (B). Immunohistochemistry-Paraffin: DDX21 Antibody [ABIN151240] - Human breast carcinoma (left) and mouse squamous cell carcinoma (right). Antibody used at a dilution of 1:200 (1ug/ml). 0.1 mL Log in to see 7至9个工作日
非结合性 ChIP, ICC, IF, IHC, IHC (p), in vitro, WB Immunocytochemistry/Immunofluorescence: DDX21 Antibody [NBP1-83310] - Staining of human cell line U-251 MG shows positivity in nucleus & nucleoli. Immunohistochemistry-Paraffin: DDX21 Antibody [NBP1-83310] - Staining of human stomach shows strong nucleolar positivity in glandular cells. 0.1 mL Log in to see 7至9个工作日
Cow 非结合性 WB 100 μg Log in to see 11至14个工作日
非结合性 WB 50 μg Log in to see 11至14个工作日
非结合性 WB DDX21 Antibody (N-term)  western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the DDX21 antibody detected the DDX21 protein (arrow). All lanes : Anti-DDX21 Antibody (N-term) at 1:2000 dilution Lane 1: 293 whole cell lysate Lane 2: A431 whole cell lysate Lane 3: Hela whole cell lysate Lane 4: HepG2 whole cell lysate Lane 5: HT-1080 whole cell lysate Lane 6: Jurkat whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 87 kDa Blocking/Dilution buffer: 5% NFDM/TBST. Dilution: 1:2000 400 μL Log in to see 10至11个工作日
非结合性 IHC, WB ABIN6272913 at 1/100 staining Mouse kidney tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. Western blot analysis of extracts of HepG2 cells, using DDX21 antibody. 100 μL Log in to see 11至12个工作日
非结合性 ICC, IF, IHC, IHC (p), WB Western Blot: DDX21 Antibody [NBP2-38311] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.Lane 2: RT-4.Lane 3: U-251 MG Immunocytochemistry/Immunofluorescence: DDX21 Antibody [NBP2-38311] - Immunofluorescent staining of human cell line U-2 OS shows positivity in nucleoli. 0.1 mL Log in to see 10至13个工作日
非结合性 ICC, IF, WB Western Blot: DDX21 Antibody [NBP2-16128] - Sample (30 ug of whole cell lysate) A: HeLa B: HepG2 7. 5% SDS PAGE gel, diluted at 1:1000. Immunocytochemistry/Immunofluorescence: DDX21 Antibody  diluted at 1:500. Blue: Hoechst 33342 staining. Scale bar = 10 um. 0.1 mL Log in to see 8至11个工作日

引用最多的anti-DDX21 抗体

  1. Cow (Bovine) Polyclonal DDX21 Primary Antibody for WB - ABIN2775198 : Henning, So, Jin, Lau, Valdez: Silencing of RNA helicase II/Gualpha inhibits mammalian ribosomal RNA production. in The Journal of biological chemistry 2003 (PubMed)
    Show all 3 Pubmed References

  2. Horse (Equine) Polyclonal DDX21 Primary Antibody for WB - ABIN2775197 : Yang, Henning, Valdez: Functional interaction between RNA helicase II/Gu(alpha) and ribosomal protein L4. in The FEBS journal 2005 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal DDX21 Primary Antibody for ChIP, ICC - ABIN4304615 : Obrdlik, Louvet, Kukalev, Naschekin, Kiseleva, Fahrenkrog, Percipalle: Nuclear myosin 1 is in complex with mature rRNA transcripts and associates with the nuclear pore basket. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal DDX21 Primary Antibody for WB - ABIN1539008 : Smith, Krumpelbeck, Jegga, Prell, Matrka, Kappes, Greis, Ali, Meetei, Wells: The nuclear DEK interactome supports multi-functionality. in Proteins 2018 (PubMed)

  5. Human Polyclonal DDX21 Primary Antibody for ICC, IF - ABIN151240 : Song, Hotz-Wagenblatt, Voit, Grummt: SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops and safeguard genome stability. in Genes & development 2018 (PubMed)


Human DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 21 (DDX21) interaction partners

  1. can drastically reduce DDX21's affinity for quadruplex, indicating that the recognition of quadruplex and specificity for telomeric repeat containing RNA quadruplex is mediated by interactions with the 2'OH of loop nucleotides

  2. Knockdown of SIRT7 leads to the same phenotype as depletion of DDX21 (i.e., increased formation of R loops and DNA double-strand breaks), indicating that SIRT7 and DDX21 cooperate to prevent R-loop accumulation, thus safeguarding genome integrity.

  3. DDX21 can suppress the expression of proteins with G4 qudruplexes in the 3 UTR of its mRNA.

  4. Results report the biogenesis and function of a box H/ACA snoRNA-ended sno-lncRNA, referred to SLERT (snoRNA-ended lncRNA enhances pre-ribosomal RNA transcription). SLERT is different from Prader-Willi Syndrome (PWS) sno-lncRNAs and plays a crucial role in rRNA biogenesis by dislodging a previously unknown clamp of DDX21 ring-shaped arrangements on Pol I complexes, thereby liberating Pol I for active rRNA transcription.

  5. In dengue virus infected cells, DDX21 translocates from nucleus to cytoplasm to active the innate immune response and thus inhibits DENV replication in the early stages of infection.

  6. DDX21 expression in breast cancer cells can promote AP-1 activity and rRNA processing, and thus, promote tumorigenesis by two independent mechanisms.

  7. Identification of several late-acting snoRNAs that bind pre-40S particles in human cells and show that their association and function in pre-40S complexes is regulated by the RNA helicase DDX21.

  8. results uncover the multifaceted role of DDX21 in multiple steps of ribosome biogenesis, and provide evidence implicating a mammalian RNA helicase in RNA modification and Pol II elongation control

  9. As sequential interaction of PB1 and NS1 with DDX21 leads to temporal regulation of viral gene expression, influenza A virus likely uses the DDX21-NS1 interaction not only to overcome restriction, but also to regulate the viral life cycle.

  10. Data indicate that DDX21, a nucleolar protein, was confirmed to associate with SET8.

  11. Studies indicated that DDX21, HNRNPC, and RCC2 were isolated from Ku86 multicomponent complex in response to DNA damage.

  12. RNA helicase II/Gualpha silencing inhibits mammalian ribosomal RNA production

  13. the function of Gu(alpha)in rRNA processing is at least partially dependent on its ability to interact with ribosomal protein L4.

  14. in addition to its transcriptional effects, c-Jun regulates rRNA processing and nucleolar compartmentalization of the rRNA processing protein DDX21

DDX21 抗原简介


DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription.

Gene names and symbols associated with DDX21

  • DEAD-box helicase 21 L homeolog (ddx21.L) 抗体
  • DExD-box helicase 21 (DDX21) 抗体
  • DEAD-box helicase 21 (ddx21) 抗体
  • DEAD (Asp-Glu-Ala-Asp) box helicase 21 (ddx21) 抗体
  • DExD-box helicase 21 (Ddx21) 抗体
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 (Ddx21) 抗体
  • AI255159 抗体
  • AL022742 抗体
  • cb960 抗体
  • D10Ertd645e 抗体
  • D10Wsu42e 抗体
  • DDX21 抗体
  • Ddx21a 抗体
  • GUA 抗体
  • GURDB 抗体
  • MGC130693 抗体
  • RH-II/GU 抗体
  • RH-II/GuA 抗体
  • wu:fi30c07 抗体
  • wu:fi34d08 抗体

Protein level used designations for DDX21

DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 , RNA helicase II/Gu , novel GUCT (NUC152) domain containing DEAD/DEAH box helicase , nucleolar RNA helicase 2 , DEAD box protein 21 , DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 21 , Gu protein , RH II/Gu , RNA helicase II/Gu alpha , gu-alpha , nucleolar RNA helicase Gu , nucleolar RNA helicase II , DEAD (Asp-Glu-Ala-Asp) box polypeptide 21a , DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 21 (RNA helicase II/Gu) , RH-II/Gualpha

398188 Xenopus laevis
450500 Pan troglodytes
734085 Xenopus (Silurana) tropicalis
799650 Danio rerio
100072661 Equus caballus
100153111 Sus scrofa
100435678 Pongo abelii
100598637 Nomascus leucogenys
9188 Homo sapiens
476891 Canis lupus familiaris
317399 Rattus norvegicus
781917 Bos taurus
56200 Mus musculus
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