anti-Coiled-Coil Domain Containing 99 (CCDC99) 抗体

Required for the localization of dynein and dynactin to the mitotic kintochore. 再加上,我们可以发Coiled-Coil Domain Containing 99 蛋白 (5)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
CCDC99 54908 Q96EA4
CCDC99 70385 Q923A2
CCDC99 303037 Q3KR99
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antibodies-online.cn销售最多的anti-Coiled-Coil Domain Containing 99 抗体

Showing 10 out of 64 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 交付 价格 详细
Cow 非结合性 WB Host: Rabbit Target Name: CCDC99 Sample Type: Hela Whole cell lysates Antibody Dilution: 1.0ug/ml  SPDL1 is supported by BioGPS gene expression data to be expressed in HeLa 100 μL 2至3个工作日
非结合性 ELISA, WB 100 μL 11至13个工作日
非结合性 WB   200 μL 13至14个工作日
非结合性 ELISA, ICC, IF, WB Western blot analysis on NIH-3T3 cell lysate using CCDC99 Antibody,The lane on the left is treated with the antigen-specific peptide. ABIN6266914 staining NIH-3T3 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody. 100 μL 11至12个工作日
非结合性 IHC (p), WB Western blot analysis in A549 cell line lysates (35ug/lane). CCDC99 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL 2至3个工作日
非结合性 IF (p), IHC (p), WB Formalin-fixed and paraffin-embedded human rectal carcinoma labeled with Anti-Spindly/CCDC99 Polyclonal Antibody, Unconjugatedused at 1:200 dilution for 40 minutes at 37°C. 100 μL 14至21个工作日
非结合性 ELISA, WB   100 μg 2至3个工作日
非结合性 ELISA, WB   100 μg 2至3个工作日
非结合性 ELISA, IHC 200 μL 12至14个工作日
Alexa Fluor 594 IF (p)   100 μL 14至21个工作日

引用最多的anti-Coiled-Coil Domain Containing 99 抗体

  1. Human Polyclonal CCDC99 Primary Antibody for IP, WB - ABIN253247 : Santaguida, Tighe, DAlise, Taylor, Musacchio: Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine. in The Journal of cell biology 2010 (PubMed)

更多抗Coiled-Coil Domain Containing 99的相互作用对抗体

Fruit Fly (Drosophila melanogaster) Coiled-Coil Domain Containing 99 (CCDC99) interaction partners

  1. Spindly is a novel regulator of mitotic dynein, functioning specifically to target dynein to kinetochores.

Arabidopsis thaliana Coiled-Coil Domain Containing 99 (CCDC99) interaction partners

  1. posttranslational modification of TCP14/15 by SPY inhibits their proteolysis.

  2. The study revealed that SPY-dependent protein O-fucosylation plays a key role in regulating plant development.

  3. SPINDLY regulates cortex proliferation by maintaining cellular redox homeostasis

  4. SPY plays a negative role in plant abiotic stress tolerance, probably by integrating environmental stress signals via gibberellic acid and Cytokinins cross talk.

  5. Data suggest that responses of leaves and flowers to CK are mediated by SPY-dependent TCP14 and TCP15 activities.

  6. spy-4 partially suppressed the reduced abundance of CONSTANS and FLOWERING LOCUS T RNA and the late flowering of gigantea mutant plants

  7. Our results demonstrate that SPY acts as both a repressor of GA responses and a positive regulator of cytokinin signaling. Hence, SPY may play a central role in the regulation of GA/cytokinin cross talk during plant development.

  8. SPY acts in the cytosol to suppress gibberellin responses and to promote cytokinin signaling.

Human Coiled-Coil Domain Containing 99 (CCDC99) interaction partners

  1. Using mass spectrometry this study identified CCDC99 as a new target of USP45. The data showed that CCDC99 and USP45 are part of the same complex and that their interaction specifically depends on the catalytic activity of USP45.

  2. Farnesylation of Spindly is essential for its localization, & thus for proper localization of dynein & dynactin, to prometaphase kinetochores. Both Spindly and CENP-E farnesylation are required for efficient chromosome congression

  3. hSpindly is farnesylated in vivo and farnesylation is essential for its interaction with the RZZ complex and hence Kinetochore localization.

  4. Spindly is not only required for kinetochore localization of dynein but is a functional component of a mechanism that couples dynein-dependent poleward movement of chromosomes to their efficient attachment to microtubules.

  5. dynein-mediated removal of Spindly from microtubule-attached kinetochores, rather than poleward transport per se, is the critical reaction in checkpoint silencing

  6. [hSpindly] Localization of human Spindly (hSpindly) to kinetochores is controlled by the Rod/Zw10/Zwilch (RZZ) complex and Aurora B.

Mouse (Murine) Coiled-Coil Domain Containing 99 (CCDC99) interaction partners

  1. Overexpression of mSpindly failed to enhance inactivation of SAC and acceleration of the meiotic process.

Coiled-Coil Domain Containing 99 (CCDC99) 抗原简介


Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex (By similarity).

Gene names and symbols associated with CCDC99

  • CG15415 gene product from transcript CG15415-RB (Spindly) 抗体
  • Tetratricopeptide repeat (TPR)-like superfamily protein (SPY) 抗体
  • spindle apparatus coiled-coil protein 1 (spdl1) 抗体
  • spindle apparatus coiled-coil protein 1 (SPDL1) 抗体
  • spindle apparatus coiled-coil protein 1 (Spdl1) 抗体
  • spindle apparatus coiled-coil protein 1 L homeolog (spdl1.L) 抗体
  • 1700018I02Rik 抗体
  • 2600001J17Rik 抗体
  • 2810049B11Rik 抗体
  • AA409762 抗体
  • Ccdc99 抗体
  • ccdc99-a 抗体
  • ccdc99-b 抗体
  • CG15415 抗体
  • Dmel\\CG15415 抗体
  • RGD1306908 抗体
  • spdl1 抗体
  • spdl1-a 抗体
  • SPINDLY 抗体

Protein level used designations for CCDC99

spindly , CG15415-PB , Spindly-PB , coiled-coil domain containing 99 , coiled-coil domain-containing protein 99 , protein Spindly , spindle apparatus coiled-coil domain-containing protein 1 , arsenite-related gene 1 protein , hSpindly , rhabdomyosarcoma antigen MU-RMS-40.4A , rrhabdomyosarcoma antigen protein MU-RMS-40.4A , spindly homolog , Coiled-coil domain-containing protein 99-A , protein Spindly-A , spindle apparatus coiled-coil domain-containing protein 1-A

33578 Drosophila melanogaster
820327 Arabidopsis thaliana
100170491 Xenopus (Silurana) tropicalis
515158 Bos taurus
54908 Homo sapiens
70385 Mus musculus
303037 Rattus norvegicus
734358 Xenopus laevis
568360 Danio rerio
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