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CLCN2 encodes a voltage-gated chloride channel. 再加上，我们可以发Chloride Channel 2 蛋白 (6)和数多这个蛋白质的别的产品。
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Human Monoclonal CLCN2 Primary Antibody for RNAi, ELISA - ABIN560397
Alessi, Andjelkovic, Caudwell, Cron, Morrice, Cohen, Hemmings: Mechanism of activation of protein kinase B by insulin and IGF-1. in The EMBO journal 1997
Show all 4 Pubmed References
Human Monoclonal CLCN2 Primary Antibody for WB - ABIN394461
Ferrer, Corneo, Davis, Wan, Miyagishima, King, Maminishkis, Marugan, Sharma, Shure, Temple, Miller, Bharti: A multiplex high-throughput gene expression assay to simultaneously detect disease and functional markers in induced pluripotent stem cell-derived retinal pigment epithelium. in Stem cells translational medicine 2014
Human Polyclonal CLCN2 Primary Antibody for ELISA, WB - ABIN4299049
Cornejo, Niemeyer, Zúñiga, Yusef, Sepúlveda, Cid: Rapid recycling of ClC-2 chloride channels between plasma membrane and endosomes: role of a tyrosine endocytosis motif in surface retrieval. in Journal of cellular physiology 2009
Identification and characterization of the zebrafish ClC (显示 CLCF1 抗体)-2a/b/c chloride channel (显示 CLCA1 抗体) orthologs.
High fat diet -treated mice lacking ClC-2 showed inhibited hepatic lipid accumulation via regulating lipid metabolism through decreasing sterol regulatory element binding p (显示 ALT 抗体)rotein (SREBP)-1c expression a (显示 TMPRSS11D 抗体)nd its downst (显示 INS 抗体)ream targeting enzymes such as fatty acid synthase (FAS), HMG-CoA reductase (HMGCR) and acetyl-Coenzyme A carboxylase (ACCalpha).
Genetic ablation of ClC-2 resulted in reduced gastric gland region, reduced parietal cell number, reduced H/K ATPase (显示 ATP4b 抗体), reduced tubulovesicles and reduced stimulated acid secretion.
Data indicate that membrane protein MLC1 is crucial for proper localization of adhesion molecule (显示 NCAM1 抗体) GlialCAM (显示 HEPACAM 抗体) and chloride channel (显示 CLCA1 抗体) ClC-2, and for changing ClC-2 currents.
Loss of ClC-2 is associated with increased development of DSS (显示 PMP22 抗体)-induced colitis.
The PCR data revealed the existence of two astrocytic subpopulations markedly differing in their gene expression levels for inwardly rectifying K+ channels (Kir4.1 (显示 KCNJ10 抗体)), K(2P) channels (TREK-1 (显示 KCNK2 抗体) and TWIK-1 (显示 KCNK1 抗体)) and Cl- channels (ClC2).
ClC-2 channels are required for colonic electroneutral absorption of NaCl and KCl.
permeant Cl(-) ions contribute to V(m)-dependent gating of the broadly distributed ClC-2 Cl() channel.
GABAA (显示 GABRg1 抗体) receptor-mediated synaptic inputs from basket cells were modulated by ClC-2. Our data reveal a previously unknown cell type-specific regulation of intracellular chloride homeostasis in the perisomatic region of hippocampal pyramidal neurons.
ClC-2 reduces barrier function in normal mucosa. Ultrastructural morphology of tight junctions and myosin light chain kinase (显示 MYLK 抗体) appear to be important to the function of ClC-2 in normal mucosa.
these findings raise the possibility that ClC-2 expression plays a subtle neuroprotective role in the aging hippocampus
ClC-2-mediated intestinal Cl - secretion restores transepithelial resistance in ischemia-injured intestine.
The inhibitory effects of ClC-2 knockout on HBVSMC proliferation and motility were associated with inactivation of the Wnt (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) signaling pathway, as evidenced by inhibition of beta-catenin (显示 CTNNB1 抗体) phosphorylation and nuclear translocation, and decrease of GSK-3beta phosphorylation and survivin and cyclin D1 (显示 CCND1 抗体) expression.
Leukoencephalopathy-causing CLCN2 mutations impair chloride channel (显示 CLCA1 抗体) gating and trafficking.
ClC-2 mRNA level was significantly increased in patients with non-alcoholic steatohepatitis, which positively correlated with the plasma levels of alanine transaminase (ALT), aspartate transaminase (AST) and insulin (显示 INS 抗体).
The findings show that RGET691 of human ClC-2 (possible binding site) plays an important functional role in fatty acid activation of human ClC-2.
Hyperpolarization activates CLC-2 mainly by driving intracellular anions into the channel pores.
The extracellular domain of GlialCAM (显示 HEPACAM 抗体) is necessary for cell junction targeting and for mediating interactions with itself or with MLC1 and ClC-2.
both ubiquitous (AP-1A) and epithelium-specific (AP-1B) forms of the tetrameric clathrin adaptor AP-1 (显示 FOSB 抗体) are capable of carrying out basolateral sorting of ClC-2.
SPAK (显示 STK39 抗体) and OSR1 (显示 OXSR1 抗体) are powerful negative regulators of the cell volume regulatory Cl- channel ClC-2
Correlation between CLC-2 gene expression and the cytoskeleton in human trabecular meshwork cells.
Our observations substantiate the concept that ClC-2 is involved in brain ion and water homoeostasis
This gene encodes a voltage-gated chloride channel. The encoded protein is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene.
chloride channel 2
, novel protein similar to vertebrate chloride channel 2 (CLCN2)
, chloride channel protein 2
, PKA-activated chloride channel ClC-2G